Nitrofor
{{distinguish|text= "Nitrofor", a trademark of the drug Nitrofurantoin{{cite web |title=Nitrofurantoin (IARC Summary & Evaluation, Volume 50, 1990) |url=https://inchem.org/documents/iarc/vol50/10-nitrofurantoin.html |website=inchem.org |access-date=5 March 2025 |date=11 November 1997}}}}
{{Chembox
| ImageFile = Nitrofor v2.svg
| ImageSize = 180px
| PIN = N,N-diethyl-2,6-dinitro-4-(trifluoromethyl)aniline
| OtherNames = {{ubl|}}
|Section1={{Chembox Identifiers
| CASNo = 5254-27-3
| ChEBI =180606
| ChEMBL =
| ChemSpiderID = 71247
| EC_number = 982-770-6
| KEGG =
| PubChem = 78912
| UNII =
| StdInChI= 1S/C11H12F3N3O4/c1-3-15(4-2)10-8(16(18)19)5-7(11(12,13)14)6-9(10)17(20)21/h5-6H,3-4H2,1-2H3
| StdInChIKey = NLLHXVBITYTYHA-UHFFFAOYSA-N
| SMILES = CCN(CC)C1=C(C=C(C=C1[N+](=O)[O-])C(F)(F)F)[N+](=O)[O-]
}}
|Section2={{Chembox Properties
| C=11|H=12|F=3|N=3|O=4
| Appearance =
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|Section3={{Chembox Hazards
| MainHazards =
| GHS_ref=[https://pubchem.ncbi.nlm.nih.gov/compound/Nitrofor#section=Safety-and-Hazards]
| GHSPictograms = {{GHS06}}{{GHS07}}{{GHS08}}{{GHS09}}
| GHSSignalWord = Danger
| HPhrases = {{H-phrases|302|317|331|351|410}}
| PPhrases = {{P-phrases|203|261|264|270|271|272|273|280|301+317|302+352|304+340|316|318|321|330|333+317|362+364|391|403+233|405|501}}
| FlashPt =
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Nitrofor is a dinitroaniline herbicide, useful for weed control in cabbage, tomato, and cotton crops.{{cite journal |last1=Nyporko |first1=A. Yu. |last2=Yemets |first2=A. I. |last3=Brytsun |first3=V. N. |last4=Lozinsky |first4=M. O. |last5=Blume |first5=Ya. B. |title=Structural and biological characterization of the tubulin interaction with dinitroanilines |journal=Cytology and Genetics |date=August 2009 |volume=43 |issue=4 |pages=267–282 |doi=10.3103/S0095452709040082}} It is not approved in the EU.{{cite journal |last1=Giglio |first1=Anita |last2=Vommaro |first2=Maria Luigia |title=Dinitroaniline herbicides: a comprehensive review of toxicity and side effects on animal non-target organisms |journal=Environmental Science and Pollution Research |date=1 November 2022 |volume=29 |issue=51 |pages=76687–76711 |doi=10.1007/s11356-022-23169-4|pmid=36175724 |bibcode=2022ESPR...2976687G |pmc=9581837 }} It can be applied at 3-6 kg/ha, and works by the inhibition of microtubule formation mode of action, making it an HRAC Group D / K3 / 3 herbicide. It appears not to be in current use anywhere.
In a Soviet test in the 1970s, nitrofor at 3 kg/Ha increased the levels of NPK (nitrogen, phosphorus and potassium), in leached heavy-loam chernozem soil. The nitrofor was pre-plant incorporated. Final NPK levels were 1.6-2.0 times greater in castor beans and 5 times greater in the seed.{{cite journal |last1=Vasil'ev |first1=D. S. |last2=Baranova |first2=L. A. |title=The effect of Nitrofor on the nutrient status of the soil in castor-bean crops |journal=Agrokhimiya |date=1975 |volume=12 |issue=4 |pages=121–123 |url=https://www.cabidigitallibrary.org/doi/full/10.5555/19752309608 |publisher=Vses. n-i Inst. maslich. Kul'tur |location=Krasnodar, USSR}}
An American test in the 1960s compared trifluralin analogs, one being nitrofor, which is equivalent to trifluralin with ethyl groups instead of propyls. Trifluralin itself was the most active agent, however nitrofor was among a few analogs recommended for further testing, still having high herbicidal activity but offering greater crop safety.{{cite journal |last1=Gentner |first1=W. A. |title=Herbicidal Properties of Trifluralin Analogs |journal=Weeds |date=April 1966 |volume=14 |issue=2 |pages=176–178 |doi=10.2307/4040959|jstor=4040959 }}