O'Brien

• O'Brien (surname), an Irish surname
• O'Brien dynasty, a powerful Irish dynasty that ruled Munster and produced several High Kings of Ireland

• O'Brien, California, an unincorporated community in Shasta County
• O'Brien, Florida, an unincorporated community in Suwannee County
• O'Brien, Oregon, a census-designated place and unincorporated community in Josephine County
• O'Brien, Texas, a city in Haskell County
• O'Brien, West Virginia, an unincorporated community in Barbour County
• O'Brien County, Iowa, a county

• O'Brien, Argentina, a town in Buenos Aires Province, Argentina
• O'Briens Hill, Queensland, a locality in the Cassowary Coast Region, Australia
• O'Brien Island, in the South Shetland Islands, Antarctica
• O'Brien Island, Chile, in the Magallanes Region, Chile

• USS O'Brien, a list of ships with this name
• Capitan O'Brien-class submarine three submarines built for the Chilean Navy in 1928–1929
• Oberon-class submarine (also known as O'Brien-class submarine), Chilean Navy submarine class
• Chilean submarine O'Brien (S22), an Oberon-class sub

• O'Brien (Nineteen Eighty-Four), the main antagonist in George Orwell's novel
• O'Brien (TV series), a British talk show presented by James O'Brien
• United States v. O'Brien, legal case ruled on by the US Supreme Court regarding draft card burning and the First Amendment's guarantee of free speech
• O'Briens Irish Sandwich Bars, a café chain based in Ireland
• O'Brien AutoGlass, the Australian subsidiary of Belron.

• Brien
• O'Brian, a surname (including a list of people with the name)
• O'Bryan (born 1961), American singer-songwriter
• Justice O'Brien (disambiguation)
• {{in title|O'Brien}}

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