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OAS3

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{About|the enzyme|the computer programming specification|OpenAPI Specification}}

{{Infobox_gene}}

2'-5'-oligoadenylate synthetase 3 is an enzyme that in humans is encoded by the OAS3 gene.{{cite journal | vauthors = Hovnanian A, Rebouillat D, Mattei MG, Levy ER, Marie I, Monaco AP, Hovanessian AG | title = The human 2',5'-oligoadenylate synthetase locus is composed of three distinct genes clustered on chromosome 12q24.2 encoding the 100-, 69-, and 40-kDa forms | journal = Genomics | volume = 52 | issue = 3 | pages = 267–77 |date=Dec 1998 | pmid = 9790745 | doi = 10.1006/geno.1998.5443 }}{{cite web | title = Entrez Gene: OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4940}}

This gene encodes an enzyme included in the 2', 5' oligoadenylate synthase family. This enzyme is induced by interferons and catalyzes the 2', 5' oligomers of ATP. These oligomers activate latent RNase L, leading to degradation of both viral and endogenous RNA. This enzyme family plays a significant role in the inhibition of cellular protein synthesis in response to viral infection.{{cite web | title = Entrez Gene: OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4940}}

References

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Further reading

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  • {{cite journal | vauthors=Hovanessian AG, Justesen J |title=The human 2'-5'oligoadenylate synthetase family: unique interferon-inducible enzymes catalyzing 2'-5' instead of 3'-5' phosphodiester bond formation. |journal=Biochimie |volume=89 |issue= 6–7 |pages= 779–88 |year= 2007 |pmid= 17408844 |doi= 10.1016/j.biochi.2007.02.003 }}
  • {{cite journal | vauthors=Silverman RH, Sengupta DN |title=Translational regulation by HIV leader RNA, TAT, and interferon-inducible enzymes. |journal=J. Exp. Pathol. |volume=5 |issue= 2 |pages= 69–77 |year= 1991 |pmid= 1708818 }}
  • {{cite journal |vauthors=Hovanessian AG, Laurent AG, Chebath J, etal |title=Identification of 69-kd and 100-kd forms of 2-5A synthetase in interferon-treated human cells by specific monoclonal antibodies. |journal=EMBO J. |volume=6 |issue= 5 |pages= 1273–80 |year= 1987 |pmid= 2440675 |doi= 10.1002/j.1460-2075.1987.tb02364.x| pmc=553929 }}
  • {{cite journal | vauthors=Marié I, Blanco J, Rebouillat D, Hovanessian AG |title=69-kDa and 100-kDa isoforms of interferon-induced (2'-5')oligoadenylate synthetase exhibit differential catalytic parameters. |journal=Eur. J. Biochem. |volume=248 |issue= 2 |pages= 558–66 |year= 1997 |pmid= 9346316 |doi=10.1111/j.1432-1033.1997.t01-1-00558.x |doi-access=free }}
  • {{cite journal | vauthors=Rebouillat D, Hovnanian A, Marié I, Hovanessian AG |title=The 100-kDa 2',5'-oligoadenylate synthetase catalyzing preferentially the synthesis of dimeric pppA2'p5'A molecules is composed of three homologous domains. |journal=J. Biol. Chem. |volume=274 |issue= 3 |pages= 1557–65 |year= 1999 |pmid= 9880533 |doi=10.1074/jbc.274.3.1557 |doi-access=free }}
  • {{cite journal |vauthors=Rebouillat D, Hovnanian A, David G, etal |title=Characterization of the gene encoding the 100-kDa form of human 2',5' oligoadenylate synthetase. |journal=Genomics |volume=70 |issue= 2 |pages= 232–40 |year= 2001 |pmid= 11112351 |doi= 10.1006/geno.2000.6382 }}
  • {{cite journal |vauthors=Ito M, Shichijo S, Tsuda N, etal |title=Molecular basis of T cell-mediated recognition of pancreatic cancer cells. |journal=Cancer Res. |volume=61 |issue= 5 |pages= 2038–46 |year= 2001 |pmid= 11280764 }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal |vauthors=Scherer SE, Muzny DM, Buhay CJ, etal |title=The finished DNA sequence of human chromosome 12. |journal=Nature |volume=440 |issue= 7082 |pages= 346–51 |year= 2006 |pmid= 16541075 |doi= 10.1038/nature04569 |bibcode=2006Natur.440..346S |doi-access= free }}

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External links

  • {{PDBe-KB2|Q9Y6K5|2'-5'-oligoadenylate synthase 3}}

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