OPN1SW
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Blue-sensitive opsin is a protein that in humans is encoded by the OPN1SW gene.{{cite journal |vauthors=Nathans J, Thomas D, Hogness DS | title = Molecular genetics of human color vision: the genes encoding blue, green, and red pigments | journal = Science | volume = 232 | issue = 4747 | pages = 193–202 |date=Apr 1986 | pmid = 2937147 | doi =10.1126/science.2937147 | bibcode = 1986Sci...232..193N | citeseerx = 10.1.1.461.5915 }}{{cite journal |vauthors=Fitzgibbon J, Appukuttan B, Gayther S, Wells D, Delhanty J, Hunt DM | title = Localisation of the human blue cone pigment gene to chromosome band 7q31.3-32 | journal = Hum Genet | volume = 93 | issue = 1 | pages = 79–80 |date=Feb 1994 | pmid = 8270261 | doi = 10.1007/bf00218919| s2cid = 43548690 }}{{cite web | title = Entrez Gene: OPN1SW opsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=611}} The OPN1SW gene provides instructions for making a protein that is essential for normal color vision. This protein is found in the retina, which is the light-sensitive tissue at the back of the eye.{{cite web | url=https://medlineplus.gov/genetics/gene/opn1sw/ | title=OPN1SW gene: MedlinePlus Genetics }}
The OPN1SW gene provides instructions for making an opsin pigment that is more sensitive to light in the blue/violet part of the visible spectrum (short-wavelength light). Cones with this pigment are called short-wavelength-sensitive or S cones. In response to light, the photopigment triggers a series of chemical reactions within an S cone. These reactions ultimately alter the cell's electrical charge, generating a signal that is transmitted to the brain. The brain combines input from all three types of cones to produce normal color vision.
See also
References
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Further reading
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- {{cite journal |vauthors=Applebury ML, Hargrave PA |title=Molecular biology of the visual pigments |journal=Vision Res. |volume=26 |issue= 12 |pages= 1881–95 |year= 1987 |pmid= 3303660 |doi=10.1016/0042-6989(86)90115-X |s2cid=34038855 }}
- {{cite journal |vauthors=Swanson WH, Cohen JM |title=Color vision |journal=Ophthalmology Clinics of North America |volume=16 |issue= 2 |pages= 179–203 |year= 2003 |pmid= 12809157 |doi=10.1016/S0896-1549(03)00004-X }}
- {{cite journal |vauthors=Weitz CJ, Went LN, Nathans J |title=Human tritanopia associated with a third amino acid substitution in the blue-sensitive visual pigment |journal=Am. J. Hum. Genet. |volume=51 |issue= 2 |pages= 444–6 |year= 1992 |pmid= 1386496 | pmc=1682686 }}
- {{cite journal | author=Weitz CJ |title=Human tritanopia associated with two amino acid substitutions in the blue-sensitive opsin |journal=Am. J. Hum. Genet. |volume=50 |issue= 3 |pages= 498–507 |year= 1992 |pmid= 1531728 | pmc=1684278 |name-list-style=vanc| author2=Miyake Y | author3=Shinzato K | display-authors=3 | last4=Montag | first4=E | last5=Zrenner | first5=E | last6=Went | first6=LN | last7=Nathans | first7=J }}
- {{cite journal |vauthors=Oprian DD, Asenjo AB, Lee N, Pelletier SL |title=Design, chemical synthesis, and expression of genes for the three human color vision pigments |journal=Biochemistry |volume=30 |issue= 48 |pages= 11367–72 |year= 1992 |pmid= 1742276 |doi=10.1021/bi00112a002 }}
- {{cite journal |vauthors=Sarkar G, Sommer SS |title=Access to a messenger RNA sequence or its protein product is not limited by tissue or species specificity |journal=Science |volume=244 |issue= 4902 |pages= 331–4 |year= 1989 |pmid= 2565599 |doi=10.1126/science.2565599 |bibcode=1989Sci...244..331S }}
- {{cite journal | author=Nathans J |title=Molecular genetics of inherited variation in human color vision |journal=Science |volume=232 |issue= 4747 |pages= 203–10 |year= 1986 |pmid= 3485310 |doi=10.1126/science.3485310 |name-list-style=vanc| author2=Piantanida TP | author3=Eddy RL | display-authors=3 | last4=Shows | first4=T. | last5=Hogness | first5=D. |bibcode=1986Sci...232..203N }}
- {{cite journal |vauthors=Shimmin LC, Mai P, Li WH |title=Sequences and evolution of human and squirrel monkey blue opsin genes |journal=J. Mol. Evol. |volume=44 |issue= 4 |pages= 378–82 |year= 1997 |pmid= 9089077 |doi=10.1007/PL00006157 |bibcode=1997JMolE..44..378S |s2cid=6425474 }}
- {{cite journal | author=Scherer SW |title=Human Chromosome 7: DNA Sequence and Biology |journal=Science |volume=300 |issue= 5620 |pages= 767–72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423 | pmc=2882961 |name-list-style=vanc| author2=Cheung J | author3=MacDonald JR | display-authors=3 | last4=Osborne | first4=LR | last5=Nakabayashi | first5=K | last6=Herbrick | first6=JA | last7=Carson | first7=AR | last8=Parker-Katiraee | first8=L | last9=Skaug | first9=J |bibcode=2003Sci...300..767S }}
- {{cite journal |vauthors=Gunther KL, Neitz J, Neitz M |title=A novel mutation in the short-wavelength-sensitive cone pigment gene associated with a tritan color vision defect |journal=Vis. Neurosci. |volume=23 |issue= 3–4 |pages= 403–9 |year= 2006 |pmid= 16961973 |doi= 10.1017/S0952523806233169 |s2cid=3748083 }}
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{{G protein-coupled receptors}}
{{Eye proteins}}
Category:G protein-coupled receptors
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