OR10J5
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Olfactory receptor 10J5 is a protein that in humans is encoded by the OR10J5 gene.{{cite web | title = Entrez Gene: OR10J5 olfactory receptor, family 10, subfamily J, member 5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=127385}}
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.
Ligands
OR10J5 is a relatively narrowly-tuned receptor, meaning it responds only to a relatively small set of related odorants.{{cite journal | vauthors = Saito H, Chi Q, Zhuang H, Matsunami H, Mainland JD | title = Odor coding by a Mammalian receptor repertoire | journal = Science Signaling | volume = 2 | issue = 60 | pages = ra9 | date = March 2009 | pmid = 19261596 | pmc = 2774247 | doi = 10.1126/scisignal.2000016 }}
Ligands include Lyral, an aldehyde with a soft floral scent.
References
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Further reading
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- {{cite journal | vauthors=Gilad Y, Bustamante CD, Lancet D, Pääbo S |title=Natural Selection on the Olfactory Receptor Gene Family in Humans and Chimpanzees |journal=Am. J. Hum. Genet. |volume=73 |issue= 3 |pages= 489–501 |year= 2003 |pmid= 12908129 |doi= 10.1086/378132 | pmc=1180675 }}
- {{cite journal | vauthors=Malnic B, Godfrey PA, Buck LB |title=The human olfactory receptor gene family |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 8 |pages= 2584–9 |year= 2004 |pmid= 14983052 |doi=10.1073/pnas.0307882100 | pmc=356993 |bibcode=2004PNAS..101.2584M |doi-access=free }}
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External links
- {{MeshName|OR10J5+protein,+human}}
{{NLM content}}
{{Olfactory receptors}}
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