OR12D3
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Olfactory receptor 12D3 is a protein that in humans is encoded by the OR12D3 gene.{{cite web | title = Entrez Gene: OR12D3 olfactory receptor, family 12, subfamily D, member 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=81797}}
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.
See also
References
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Further reading
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- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal |vauthors=Volz A, Ehlers A, Younger R, etal |title=Complex transcription and splicing of odorant receptor genes. |journal=J. Biol. Chem. |volume=278 |issue= 22 |pages= 19691–701 |year= 2003 |pmid= 12637542 |doi= 10.1074/jbc.M212424200 |doi-access= free }}
- {{cite journal |vauthors=Mungall AJ, Palmer SA, Sims SK, etal |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 |bibcode=2003Natur.425..805M |doi-access= free }}
- {{cite journal | vauthors=Malnic B, Godfrey PA, Buck LB |title=The human olfactory receptor gene family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 8 |pages= 2584–9 |year= 2004 |pmid= 14983052 |doi=10.1073/pnas.0307882100 | pmc=356993 |bibcode=2004PNAS..101.2584M |doi-access=free }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Santos PS, Füst G, Prohászka Z, etal |title=Association of smoking behavior with an odorant receptor allele telomeric to the human major histocompatibility complex. |journal=Genet. Test. |volume=12 |issue=4 |pages=481–6 |year=2008 |pmid=18939942 |doi=10.1089/gte.2008.0029 | pmc=2635552 }}
- {{cite journal |vauthors=Santos PS, Kellermann T, Uchanska-Ziegler B, etal |title=Genomic architecture of MHC-linked odorant receptor gene repertoires among 16 vertebrate species. |journal=Immunogenetics |volume=62 |issue=9 |pages=569–84 |year=2010 |pmid=20680261 |doi=10.1007/s00251-010-0468-6 |s2cid=23003444 }}
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External links
- {{MeshName|OR12D3+protein,+human}}
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{{Olfactory receptors}}
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