OR1E1
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Olfactory receptor 1E1 is a protein that in humans is encoded by the OR1E1 gene.{{cite journal | vauthors = Ben-Arie N, Lancet D, Taylor C, Khen M, Walker N, Ledbetter DH, Carrozzo R, Patel K, Sheer D, Lehrach H| title = Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire | journal = Hum Mol Genet | volume = 3 | issue = 2 | pages = 229–35 |date=Jul 1994 | pmid = 8004088 | doi =10.1093/hmg/3.2.229 |display-authors=etal}}{{cite journal | vauthors = Parmentier M, Libert F, Schurmans S, Schiffmann S, Lefort A, Eggerickx D, Ledent C, Mollereau C, Gerard C, Perret J| title = Expression of members of the putative olfactory receptor gene family in mammalian germ cells | journal = Nature | volume = 355 | issue = 6359 | pages = 453–5 |date=Mar 1992 | pmid = 1370859 | doi = 10.1038/355453a0 | bibcode = 1992Natur.355..453P | s2cid = 43926 |display-authors=etal}}{{cite web | title = Entrez Gene: OR1E1 olfactory receptor, family 1, subfamily E, member 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8387}}
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.
See also
References
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Further reading
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- {{cite journal |vauthors=Rouquier S, Taviaux S, Trask BJ, etal |title=Distribution of olfactory receptor genes in the human genome |journal=Nat. Genet. |volume=18 |issue= 3 |pages= 243–50 |year= 1998 |pmid= 9500546 |doi= 10.1038/ng0398-243 |s2cid=31129045 }}
- {{cite journal |vauthors=Glusman G, Sosinsky A, Ben-Asher E, etal |title=Sequence, structure, and evolution of a complete human olfactory receptor gene cluster |journal=Genomics |volume=63 |issue= 2 |pages= 227–45 |year= 2000 |pmid= 10673334 |doi= 10.1006/geno.1999.6030 |s2cid=23416814 }}
- {{cite journal | vauthors=Rouquier S, Blancher A, Giorgi D |title=The olfactory receptor gene repertoire in primates and mouse: evidence for reduction of the functional fraction in primates |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 6 |pages= 2870–4 |year= 2000 |pmid= 10706615 |doi= 10.1073/pnas.040580197 | pmc=16022 |bibcode=2000PNAS...97.2870R |doi-access=free }}
- {{cite journal |vauthors=Fuchs T, Malecova B, Linhart C, etal |title=DEFOG: a practical scheme for deciphering families of genes |journal=Genomics |volume=80 |issue= 3 |pages= 295–302 |year= 2003 |pmid= 12213199 |doi=10.1006/geno.2002.6830 }}
- {{cite journal | vauthors=Malnic B, Godfrey PA, Buck LB |title=The human olfactory receptor gene family |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 8 |pages= 2584–9 |year= 2004 |pmid= 14983052 |doi=10.1073/pnas.0307882100 | pmc=356993 |bibcode=2004PNAS..101.2584M |doi-access=free }}
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External links
- {{MeshName|OR1E1+protein,+human}}
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{{Olfactory receptors}}
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