OR1E3
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Olfactory receptor family 1 subfamily E member 3 (gene/pseudogene) is a protein that in humans is encoded by the OR1E3 gene.
{{cite web
| title = Entrez Gene: Olfactory receptor family 1 subfamily E member 3 (gene/pseudogene)
| url = http://www.ncbi.nlm.nih.gov/gene/8389
| access-date = 2020-04-12
}}
Function
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008].
Odorant repertoire
Ketones, in particular acetophenone, act as agonists for OR1E3.{{cite journal | vauthors = Matarazzo V, Clot-Faybesse O, Marcet B, Guiraudie-Capraz G, Atanasova B, Devauchelle G, Cerutti M, Etiévant P, Ronin C | display-authors = 6 | title = Functional characterization of two human olfactory receptors expressed in the baculovirus Sf9 insect cell system | journal = Chemical Senses | volume = 30 | issue = 3 | pages = 195–207 | date = March 2005 | pmid = 15741602 | doi = 10.1093/chemse/bji015 | doi-access = free }}
From associations to other olfactory receptors, OR1E3 was found to be associated with the odor tendencies "medicine", "phenol", and "harsh".{{cite journal | vauthors = Audouze K, Tromelin A, Le Bon AM, Belloir C, Petersen RK, Kristiansen K, Brunak S, Taboureau O | display-authors = 6 | title = Identification of odorant-receptor interactions by global mapping of the human odorome | journal = PLOS ONE | volume = 9 | issue = 4 | pages = e93037 | date = 2014 | pmid = 24695519 | pmc = 3973694 | doi = 10.1371/journal.pone.0093037 | bibcode = 2014PLoSO...993037A | doi-access = free }}