OR1G1
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Olfactory receptor 1G1 is a protein that in humans is encoded by the OR1G1 gene.{{cite journal | vauthors = Ben-Arie N, Lancet D, Taylor C, Khen M, Walker N, Ledbetter DH, Carrozzo R, Patel K, Sheer D, Lehrach H | display-authors = 6 | title = Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire | journal = Human Molecular Genetics | volume = 3 | issue = 2 | pages = 229–35 | date = February 1994 | pmid = 8004088 | doi = 10.1093/hmg/3.2.229 }}{{cite journal | vauthors = Rouquier S, Taviaux S, Trask BJ, Brand-Arpon V, van den Engh G, Demaille J, Giorgi D | title = Distribution of olfactory receptor genes in the human genome | journal = Nature Genetics | volume = 18 | issue = 3 | pages = 243–50 | date = March 1998 | pmid = 9500546 | doi = 10.1038/ng0398-243 | s2cid = 31129045 }}{{cite web | title = Entrez Gene: OR1G1 olfactory receptor, family 1, subfamily G, member 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8390}}
Function
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.
Ligands
The OR1G1 receptor is associated with sensory sensations including "waxy", "fatty", and "rose",{{cite journal | vauthors = Sanz G, Thomas-Danguin T, Hamdani EH, Le Poupon C, Briand L, Pernollet JC, Guichard E, Tromelin A | display-authors = 6 | title = Relationships between molecular structure and perceived odor quality of ligands for a human olfactory receptor | journal = Chemical Senses | volume = 33 | issue = 7 | pages = 639–53 | date = September 2008 | pmid = 18603653 | doi = 10.1093/chemse/bjn032 | doi-access = free | citeseerx = 10.1.1.563.7800 }} and also "fruity" and "sweet".{{cite journal | vauthors = Audouze K, Tromelin A, Le Bon AM, Belloir C, Petersen RK, Kristiansen K, Brunak S, Taboureau O | display-authors = 6 | title = Identification of odorant-receptor interactions by global mapping of the human odorome | journal = PLOS ONE | volume = 9 | issue = 4 | pages = e93037 | date = 2014 | pmid = 24695519 | pmc = 3973694 | doi = 10.1371/journal.pone.0093037 | bibcode = 2014PLoSO...993037A | doi-access = free }}
Compared to other olfactory receptors such as OR52D1, OR1G1 is broadly tuned to respond to odorants in different chemical classes, but it is sensitive to chain length, responding most strongly to chains of 9-10 carbons.{{cite journal | vauthors = Sanz G, Schlegel C, Pernollet JC, Briand L | title = Comparison of odorant specificity of two human olfactory receptors from different phylogenetic classes and evidence for antagonism | journal = Chemical Senses | volume = 30 | issue = 1 | pages = 69–80 | date = January 2005 | pmid = 15647465 | doi = 10.1093/chemse/bji002 | doi-access = free }}
Examples of agonists include:
- nonanal (strong)
- 1-nonanol (strong)
- 2-ethyl-1-hexanol (strong)
- γ-decalactone (strong)
- ethyl isobutyrate (strong)
- 1-octanol
- celery ketone
- citral
- isoamyl acetate{{cite journal | vauthors = Matarazzo V, Clot-Faybesse O, Marcet B, Guiraudie-Capraz G, Atanasova B, Devauchelle G, Cerutti M, Etiévant P, Ronin C | display-authors = 6 | title = Functional characterization of two human olfactory receptors expressed in the baculovirus Sf9 insect cell system | journal = Chemical Senses | volume = 30 | issue = 3 | pages = 195–207 | date = March 2005 | pmid = 15741602 | doi = 10.1093/chemse/bji015 | doi-access = free }}
Example antagonists include:
The pattern of 6-carbon antagonists compared to ~9-carbon agonists is likely explained by OR1G1 having a deep pocket at its binding site, such that the 6-carbon molecules block the opening, but do not reach the bottom of the deep pocket as required to activate the signal transduction chain.
See also
References
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Further reading
{{refbegin | 2}}
- {{cite journal | vauthors = Glusman G, Sosinsky A, Ben-Asher E, Avidan N, Sonkin D, Bahar A, Rosenthal A, Clifton S, Roe B, Ferraz C, Demaille J, Lancet D | display-authors = 6 | title = Sequence, structure, and evolution of a complete human olfactory receptor gene cluster | journal = Genomics | volume = 63 | issue = 2 | pages = 227–45 | date = January 2000 | pmid = 10673334 | doi = 10.1006/geno.1999.6030 | s2cid = 23416814 }}
- {{cite journal | vauthors = Matarazzo V, Zsürger N, Guillemot JC, Clot-Faybesse O, Botto JM, Dal Farra C, Crowe M, Demaille J, Vincent JP, Mazella J, Ronin C | display-authors = 6 | title = Porcine odorant-binding protein selectively binds to a human olfactory receptor | journal = Chemical Senses | volume = 27 | issue = 8 | pages = 691–701 | date = October 2002 | pmid = 12379593 | doi = 10.1093/chemse/27.8.691 | doi-access = free }}
- {{cite journal | vauthors = Malnic B, Godfrey PA, Buck LB | title = The human olfactory receptor gene family | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 8 | pages = 2584–9 | date = February 2004 | pmid = 14983052 | pmc = 356993 | doi = 10.1073/pnas.0307882100 | bibcode = 2004PNAS..101.2584M | doi-access = free }}
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External links
- {{MeshName|OR1G1+protein,+human}}
{{NLM content}}
{{Olfactory receptors}}