OR2H2
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Olfactory receptor 2H2 is a protein that in humans is encoded by the OR2H2 gene.{{cite web | title = Entrez Gene: OR2H2 olfactory receptor, family 2, subfamily H, member 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7932}}
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.{{cite web | title = Entrez Gene: OR2H2 olfactory receptor, family 2, subfamily H, member 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7932}}
See also
References
{{reflist}}
Further reading
{{refbegin | 2}}
- {{cite journal | vauthors=Fan W, Liu YC, Parimoo S, Weissman SM |title=Olfactory receptor-like genes are located in the human major histocompatibility complex. |journal=Genomics |volume=27 |issue= 1 |pages= 119–23 |year= 1995 |pmid= 7665158 |doi= 10.1006/geno.1995.1013 |doi-access= free }}
- {{cite journal |vauthors=Fan W, Cai W, Parimoo S, etal |title=Identification of seven new human MHC class I region genes around the HLA-F locus. |journal=Immunogenetics |volume=44 |issue= 2 |pages= 97–103 |year= 1996 |pmid= 8662070 |doi=10.1007/BF02660056 |s2cid=21628804 }}
- {{cite journal |vauthors=Eklund AC, Belchak MM, Lapidos K, etal |title=Polymorphisms in the HLA-linked olfactory receptor genes in the Hutterites. |journal=Hum. Immunol. |volume=61 |issue= 7 |pages= 711–7 |year= 2000 |pmid= 10880742 |doi=10.1016/S0198-8859(00)00132-4 }}
- {{cite journal |vauthors=Younger RM, Amadou C, Bethel G, etal |title=Characterization of clustered MHC-linked olfactory receptor genes in human and mouse. |journal=Genome Res. |volume=11 |issue= 4 |pages= 519–30 |year= 2001 |pmid= 11282967 |doi= 10.1101/gr.gr-1603r | pmc=311051 }}
- {{cite journal |vauthors=Fuchs T, Malecova B, Linhart C, etal |title=DEFOG: a practical scheme for deciphering families of genes. |journal=Genomics |volume=80 |issue= 3 |pages= 295–302 |year= 2003 |pmid= 12213199 |doi=10.1006/geno.2002.6830 |citeseerx=10.1.1.135.3652 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal |vauthors=Volz A, Ehlers A, Younger R, etal |title=Complex transcription and splicing of odorant receptor genes. |journal=J. Biol. Chem. |volume=278 |issue= 22 |pages= 19691–701 |year= 2003 |pmid= 12637542 |doi= 10.1074/jbc.M212424200 |doi-access= free }}
- {{cite journal |vauthors=Mungall AJ, Palmer SA, Sims SK, etal |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 |bibcode=2003Natur.425..805M |doi-access= free }}
- {{cite journal | vauthors=Malnic B, Godfrey PA, Buck LB |title=The human olfactory receptor gene family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 8 |pages= 2584–9 |year= 2004 |pmid= 14983052 |doi=10.1073/pnas.0307882100 | pmc=356993 |bibcode=2004PNAS..101.2584M |doi-access=free }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Santos PS, Kellermann T, Uchanska-Ziegler B, etal |title=Genomic architecture of MHC-linked odorant receptor gene repertoires among 16 vertebrate species. |journal=Immunogenetics |volume=62 |issue=9 |pages=569–84 |year=2010 |pmid=20680261 |doi=10.1007/s00251-010-0468-6 |s2cid=23003444 }}
{{refend}}
External links
- {{MeshName|OR2H2+protein,+human}}
{{NLM content}}
{{Olfactory receptors}}
{{transmembranereceptor-stub}}