OR51E2
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Olfactory receptor 51E2 is a protein that in humans is encoded by the OR51E2 gene.{{cite journal | vauthors = Xu LL, Stackhouse BG, Florence K, Zhang W, Shanmugam N, Sesterhenn IA, Zou Z, Srikantan V, Augustus M, Roschke V, Carter K, McLeod DG, Moul JW, Soppett D, Srivastava S | display-authors = 6 | title = PSGR, a novel prostate-specific gene with homology to a G protein-coupled receptor, is overexpressed in prostate cancer | journal = Cancer Research | volume = 60 | issue = 23 | pages = 6568–6572 | date = December 2000 | pmid = 11118034 }}{{cite web | title = Entrez Gene: OR51E2 olfactory receptor, family 51, subfamily E, member 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=81285}}
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.
Structure
Image:OR51E2.png (green) complexed with miniGs399 and a propionic acid ligand (orange).]]
Its structure was determined in 2023, the first elucidation of the structure of a human olfactory receptor.{{PDB|8F76}}; {{cite journal | vauthors = Billesbølle CB, de March CA, van der Velden WJ, Ma N, Tewari J, Del Torrent CL, Li L, Faust B, Vaidehi N, Matsunami H, Manglik A | display-authors = 6 | title = Structural basis of odorant recognition by a human odorant receptor | journal = Nature | volume = 615 | issue = 7953 | pages = 742–749 | date = March 2023 | pmid = 36922591 | doi = 10.1038/s41586-023-05798-y | bibcode = 2023Natur.615..742B | s2cid = 254975795 | pmc = 10580732 }}{{cite journal | vauthors = Kim SE |title=Scientists sniff out the structure of a human olfactory receptor |journal=Chemical & Engineering News |year=2023 |volume=101 |issue=10 |page=6 |doi=10.1021/cen-10110-scicon3}}{{Cite web | vauthors = Parry W |date=1 May 2023 |title=How a Human Smell Receptor Works Is Finally Revealed |url=https://www.quantamagazine.org/how-a-human-smell-receptor-works-is-finally-revealed-20230501/ |website=Quanta Magazine}}
Ligands
OR51E2 is a relatively narrowly tuned olfactory receptor, meaning it responds only to a relatively small set of related odorants.{{cite journal | vauthors = Saito H, Chi Q, Zhuang H, Matsunami H, Mainland JD | title = Odor coding by a Mammalian receptor repertoire | journal = Science Signaling | volume = 2 | issue = 60 | pages = ra9 | date = March 2009 | pmid = 19261596 | pmc = 2774247 | doi = 10.1126/scisignal.2000016 }}
OR51E2 responds to short-chain fatty acids,{{cite journal | vauthors = Pluznick JL, Protzko RJ, Gevorgyan H, Peterlin Z, Sipos A, Han J, Brunet I, Wan LX, Rey F, Wang T, Firestein SJ, Yanagisawa M, Gordon JI, Eichmann A, Peti-Peterdi J, Caplan MJ | display-authors = 6 | title = Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 110 | issue = 11 | pages = 4410–4415 | date = March 2013 | pmid = 23401498 | pmc = 3600440 | doi = 10.1073/pnas.1215927110 | doi-access = free | bibcode = 2013PNAS..110.4410P }} including in particular propionic acid.
See also
{{clear}}
References
{{reflist}}
Further reading
{{refbegin | 2}}
- {{cite journal | vauthors = Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O | display-authors = 6 | title = Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence | journal = Nature | volume = 377 | issue = 6547 Suppl | pages = 3–174 | date = September 1995 | pmid = 7566098 | url = http://www.columbia.edu/itc/biology/pollack/w4065/client_edit/readings/nature377_3.pdf }}
- {{cite journal | vauthors = Xia C, Ma W, Wang F, Liu M | title = Identification of a prostate-specific G-protein coupled receptor in prostate cancer | journal = Oncogene | volume = 20 | issue = 41 | pages = 5903–5907 | date = September 2001 | pmid = 11593396 | doi = 10.1038/sj.onc.1204803 | doi-access = free }}
- {{cite journal | vauthors = Yuan TT, Toy P, McClary JA, Lin RJ, Miyamoto NG, Kretschmer PJ | title = Cloning and genetic characterization of an evolutionarily conserved human olfactory receptor that is differentially expressed across species | journal = Gene | volume = 278 | issue = 1–2 | pages = 41–51 | date = October 2001 | pmid = 11707321 | doi = 10.1016/S0378-1119(01)00709-0 }}
- {{cite journal | vauthors = Malnic B, Godfrey PA, Buck LB | title = The human olfactory receptor gene family | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 8 | pages = 2584–2589 | date = February 2004 | pmid = 14983052 | pmc = 356993 | doi = 10.1073/pnas.0307882100 | doi-access = free | bibcode = 2004PNAS..101.2584M }}
- {{cite journal | vauthors = Weng J, Wang J, Cai Y, Stafford LJ, Mitchell D, Ittmann M, Liu M | title = Increased expression of prostate-specific G-protein-coupled receptor in human prostate intraepithelial neoplasia and prostate cancers | journal = International Journal of Cancer | volume = 113 | issue = 5 | pages = 811–818 | date = February 2005 | pmid = 15499628 | doi = 10.1002/ijc.20635 | s2cid = 27473061 | doi-access = free }}
- {{cite journal | vauthors = Weng J, Ma W, Mitchell D, Zhang J, Liu M | title = Regulation of human prostate-specific G-protein coupled receptor, PSGR, by two distinct promoters and growth factors | journal = Journal of Cellular Biochemistry | volume = 96 | issue = 5 | pages = 1034–1048 | date = December 2005 | pmid = 16149059 | doi = 10.1002/jcb.20600 | s2cid = 20908653 }}
- {{cite journal | vauthors = Xu LL, Sun C, Petrovics G, Makarem M, Furusato B, Zhang W, Sesterhenn IA, McLeod DG, Sun L, Moul JW, Srivastava S | display-authors = 6 | title = Quantitative expression profile of PSGR in prostate cancer | journal = Prostate Cancer and Prostatic Diseases | volume = 9 | issue = 1 | pages = 56–61 | year = 2006 | pmid = 16231015 | doi = 10.1038/sj.pcan.4500836 | doi-access = free }}
- {{cite journal | vauthors = Wang J, Weng J, Cai Y, Penland R, Liu M, Ittmann M | title = The prostate-specific G-protein coupled receptors PSGR and PSGR2 are prostate cancer biomarkers that are complementary to alpha-methylacyl-CoA racemase | journal = The Prostate | volume = 66 | issue = 8 | pages = 847–857 | date = June 2006 | pmid = 16491480 | doi = 10.1002/pros.20389 | s2cid = 25548828 }}
{{refend}}
External links
- {{MeshName|OR51E2+protein,+human}}
{{NLM content}}
{{Olfactory receptors}}
{{transmembranereceptor-stub}}