OR5P3
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Olfactory receptor 5P3 is a protein that in humans is encoded by the OR5P3 gene.{{cite web | title = Entrez Gene: OR5P3 olfactory receptor, family 5, subfamily P, member 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=120066}}
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.
Ligands
The OR5P3 receptor is associated with examples of ligands includes:{{cite journal | vauthors = Audouze K, Tromelin A, Le Bon AM, Belloir C, Petersen RK, Kristiansen K, Brunak S, Taboureau O | display-authors = 6 | title = Identification of odorant-receptor interactions by global mapping of the human odorome | journal = PLOS ONE | volume = 9 | issue = 4 | pages = e93037 | date = 2014 | pmid = 24695519 | pmc = 3973694 | doi = 10.1371/journal.pone.0093037 | bibcode = 2014PLoSO...993037A | doi-access = free }}{{cite journal | vauthors = Sanz G, Thomas-Danguin T, Hamdani EH, Le Poupon C, Briand L, Pernollet JC, Guichard E, Tromelin A | display-authors = 6 | title = Relationships between molecular structure and perceived odor quality of ligands for a human olfactory receptor | journal = Chemical Senses | volume = 33 | issue = 7 | pages = 639–53 | date = September 2008 | pmid = 18603653 | doi = 10.1093/chemse/bjn032 | doi-access = free }}
- 1-octanol
- celery ketone
- (-)-carvone
See also
References
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Further reading
{{refbegin | 2}}
- {{cite journal | vauthors = Gaudin JC, Breuils L, Haertlé T | title = New GPCRs from a human lingual cDNA library | journal = Chemical Senses | volume = 26 | issue = 9 | pages = 1157–66 | date = November 2001 | pmid = 11705801 | doi = 10.1093/chemse/26.9.1157 | doi-access = free }}
- {{cite journal | vauthors = Fuchs T, Malecova B, Linhart C, Sharan R, Khen M, Herwig R, Shmulevich D, Elkon R, Steinfath M, O'Brien JK, Radelof U, Lehrach H, Lancet D, Shamir R | display-authors = 6 | title = DEFOG: a practical scheme for deciphering families of genes | journal = Genomics | volume = 80 | issue = 3 | pages = 295–302 | date = September 2002 | pmid = 12213199 | doi = 10.1006/geno.2002.6830 }}
- {{cite journal | vauthors = Malnic B, Godfrey PA, Buck LB | title = The human olfactory receptor gene family | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 8 | pages = 2584–9 | date = February 2004 | pmid = 14983052 | pmc = 356993 | doi = 10.1073/pnas.0307882100 | bibcode = 2004PNAS..101.2584M | doi-access = free }}
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External links
- {{MeshName|OR5P3+protein,+human}}
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{{Olfactory receptors}}
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