OR7D4

{{Short description|Protein-coding gene in the species Homo sapiens}}

Olfactory receptor 7D4 is a protein that in humans is encoded by the OR7D4 gene.{{cite journal | vauthors = Fuchs T, Malecova B, Linhart C, Sharan R, Khen M, Herwig R, Shmulevich D, Elkon R, Steinfath M, O'Brien JK, Radelof U, Lehrach H, Lancet D, Shamir R | title = DEFOG: a practical scheme for deciphering families of genes | journal = Genomics | volume = 80 | issue = 3 | pages = 295–302 | date = September 2002 | pmid = 12213199 | doi = 10.1006/geno.2002.6830 | citeseerx = 10.1.1.135.3652 }}{{cite journal | vauthors = Malnic B, Godfrey PA, Buck LB | title = The human olfactory receptor gene family | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 8 | pages = 2584–9 | date = February 2004 | pmid = 14983052 | pmc = 356993 | doi = 10.1073/pnas.0307882100 | bibcode = 2004PNAS..101.2584M | doi-access = free }}{{cite journal | vauthors = Keller A, Zhuang H, Chi Q, Vosshall LB, Matsunami H | title = Genetic variation in a human odorant receptor alters odour perception | journal = Nature | volume = 449 | issue = 7161 | pages = 468–72 | date = September 2007 | pmid = 17873857 | doi = 10.1038/nature06162 | bibcode = 2007Natur.449..468K | s2cid = 4417235 | url = https://zenodo.org/record/896285 }}{{MeshName|OR7D4+protein,+human}}{{cite journal | vauthors = Lunde K, Egelandsdal B, Skuterud E, Mainland JD, Lea T, Hersleth M, Matsunami H | title = Genetic variation of an odorant receptor OR7D4 and sensory perception of cooked meat containing androstenone | journal = PLOS ONE | volume = 7 | issue = 5 | pages = e35259 | year = 2012 | pmid = 22567099 | pmc = 3342276 | doi = 10.1371/journal.pone.0035259 | bibcode = 2012PLoSO...735259L | editor1-last = Behrens | editor1-first = Maik | doi-access = free }}{{cite journal | vauthors = Wysocki CJ, Beauchamp GK | title = Ability to smell androstenone is genetically determined | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 81 | issue = 15 | pages = 4899–902 | date = August 1984 | pmid = 6589634 | pmc = 391599 | doi = 10.1073/pnas.81.15.4899 | bibcode = 1984PNAS...81.4899W | doi-access = free }}

Function

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.{{cite web | title = Entrez Gene: OR7D4 olfactory receptor, family 7, subfamily D, member 4| url = https://www.ncbi.nlm.nih.gov/gene/125958| access-date =2013-12-17 }}

Ligands

Androstadienone{{cite journal | vauthors = Hornung J, Noack H, Thomas M, Farger G, Nieratschker V, Freiherr J, Derntl B | title = Bayesian informed evidence against modulation of androstadienone-effects by genotypic receptor variants and participant sex: A study assessing Stroop interference control, mood and olfaction | journal = Hormones and Behavior | volume = 98 | pages = 45–54 | date = February 2018 | pmid = 29246659 | doi = 10.1016/j.yhbeh.2017.12.003 | s2cid = 3577638 }}
Androstenone{{cite journal | vauthors = de March CA, Topin J, Bruguera E, Novikov G, Ikegami K, Matsunami H, Golebiowski J | title = Odorant Receptor 7D4 Activation Dynamics | journal = Angewandte Chemie | volume = 57 | issue = 17 | pages = 4554–4558 | date = April 2018 | pmid = 29462498 | doi = 10.1002/anie.201713065 | pmc = 6268213 }}

People with the OR7D4 R88W/T133M polymorphism are less sensitive to these odorants and find them less offensive smelling, as they are characteristically described as "sweaty".

References

Category:Olfactory receptors