ORM1
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Alpha-1-acid glycoprotein 1 is a protein that in humans is encoded by the ORM1 gene.{{cite web | title = Entrez Gene: ORM1 orosomucoid 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5004}}
This gene encodes a key acute phase plasma protein. Because of its increase due to acute inflammation, this protein is classified as an acute-phase reactant. The specific function of this protein has not yet been determined; however, it may be involved in aspects of immunosuppression.
Interactions
ORM1 has been shown to interact with Plasminogen activator inhibitor-1.{{cite journal |last=Boncela |first=J |author2=Papiewska I |author3=Fijalkowska I |author4=Walkowiak B |author5=Cierniewski C S |date=Sep 2001 |title=Acute phase protein alpha 1-acid glycoprotein interacts with plasminogen activator inhibitor type 1 and stabilizes its inhibitory activity |journal=J. Biol. Chem. |volume=276 |issue=38 |pages=35305–11 |location = United States| issn = 0021-9258| pmid = 11418606 |doi = 10.1074/jbc.M104028200 |doi-access=free }}
See also
References
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Further reading
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- {{cite journal |vauthors=Treuheit MJ, Costello CE, Halsall HB |title=Analysis of the five glycosylation sites of human alpha 1-acid glycoprotein. |journal=Biochem. J. |volume=283 |issue= 1|pages= 105–12 |year= 1992 |pmid= 1567356 |doi= 10.1042/bj2830105| pmc=1131000 }}
- {{cite journal |vauthors=Dente L, Ciliberto G, Cortese R |title=Structure of the human alpha 1-acid glycoprotein gene: sequence homology with other human acute phase protein genes. |journal=Nucleic Acids Res. |volume=13 |issue= 11 |pages= 3941–52 |year= 1985 |pmid= 2409529 |doi=10.1093/nar/13.11.3941 | pmc=341288 }}
- {{cite journal |vauthors=Dubé JY, Paradis G, Têtu B, Tremblay RR |title=Synthesis of alpha 1-acid glycoprotein by the human prostate. |journal=Prostate |volume=15 |issue= 3 |pages= 251–8 |year= 1989 |pmid= 2479939 |doi=10.1002/pros.2990150305 |s2cid=84445745 }}
- {{cite journal |vauthors=Zuffardi O, Caiulo A, Maraschio P, etal |title=Regional assignment of the loci for adenylate kinase to 9q32 and for alpha 1-acid glycoprotein to 9q31-q32. A locus for Goltz syndrome in region 9q32-qter? |journal=Hum. Genet. |volume=82 |issue= 1 |pages= 17–9 |year= 1989 |pmid= 2541064 |doi= 10.1007/bf00288264|s2cid=42021177 }}
- {{cite journal |vauthors=Dente L, Pizza MG, Metspalu A, Cortese R |title=Structure and expression of the genes coding for human alpha 1-acid glycoprotein. |journal=EMBO J. |volume=6 |issue= 8 |pages= 2289–96 |year= 1987 |pmid= 2822385 |doi= 10.1002/j.1460-2075.1987.tb02503.x| pmc=553631 }}
- {{cite journal |vauthors=Merritt CM, Board PG |title=Structure and characterisation of a duplicated human alpha 1 acid glycoprotein gene. |journal=Gene |volume=66 |issue= 1 |pages= 97–106 |year= 1988 |pmid= 2970990 |doi=10.1016/0378-1119(88)90228-4 }}
- {{cite journal |vauthors=Dente L, Rüther U, Tripodi M, etal |title=Expression of human alpha 1-acid glycoprotein genes in cultured cells and in transgenic mice. |journal=Genes Dev. |volume=2 |issue= 2 |pages= 259–66 |year= 1988 |pmid= 3360326 |doi=10.1101/gad.2.2.259 |doi-access=free }}
- {{cite journal |vauthors=Rocchi M, Roncuzzi L, Santamaria R, etal |title=Mapping through somatic cell hybrids and cDNA probes of protein C to chromosome 2, factor X to chromosome 13, and alpha 1-acid glycoprotein to chromosome 9. |journal=Hum. Genet. |volume=74 |issue= 1 |pages= 30–3 |year= 1986 |pmid= 3463531 |doi=10.1007/BF00278781 |s2cid=34725840 }}
- {{cite journal |vauthors=Board PG, Jones IM, Bentley AK |title=Molecular cloning and nucleotide sequence of human alpha 1 acid glycoprotein cDNA. |journal=Gene |volume=44 |issue= 1 |pages= 127–31 |year= 1986 |pmid= 3770479 |doi=10.1016/0378-1119(86)90051-X }}
- {{cite journal |vauthors=Krauss E, Polnaszek CF, Scheeler DA, etal |title=Interaction between human serum albumin and alpha 1-acid glycoprotein in the binding of lidocaine to purified protein fractions and sera. |journal=J. Pharmacol. Exp. Ther. |volume=239 |issue= 3 |pages= 754–9 |year= 1987 |pmid= 3795040 }}
- {{cite journal |vauthors=Ikenaka T, Ishiguro M, Emura J, etal |title=Isolation and partial characterization of the cyanogen bromide fragments of 1 -acid glycoprotein and the elucidation of the amino acid sequence of the carboxyl-terminal cyanogen bromide fragment. |journal=Biochemistry |volume=11 |issue= 20 |pages= 3817–29 |year= 1972 |pmid= 4561179 |doi=10.1021/bi00770a022 }}
- {{cite journal |vauthors=Schmid K, Bürgi W, Collins JH, Nanno S |title=The disulfide bonds of alpha1-acid glycoprotein. |journal=Biochemistry |volume=13 |issue= 13 |pages= 2694–7 |year= 1974 |pmid= 4603214 |doi=10.1021/bi00710a006 }}
- {{cite journal |vauthors=Schmid K, Kaufmann H, Isemura S, etal |title=Structure of 1 -acid glycoprotein. The complete amino acid sequence, multiple amino acid substitutions, and homology with the immunoglobulins. |journal=Biochemistry |volume=12 |issue= 14 |pages= 2711–24 |year= 1973 |pmid= 4711474 |doi=10.1021/bi00738a026 }}
- {{cite journal |vauthors=Mbuyi JM, Dequeker J, Bloemmen F, Stevens E |title=Plasma proteins in human cortical bone: enrichment of alpha 2 HS-glycoprotein, alpha 1 acid-glycoprotein, and IgE. |journal=Calcif. Tissue Int. |volume=34 |issue= 3 |pages= 229–31 |year= 1982 |pmid= 6809283 |doi=10.1007/BF02411242 |s2cid=13305518 }}
- {{cite journal |vauthors=Rabehi L, Ferriere F, Saffar L, Gattegno L |title=alpha 1-Acid glycoprotein binds human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein via N-linked glycans. |journal=Glycoconj. J. |volume=12 |issue= 1 |pages= 7–16 |year= 1995 |pmid= 7795416 |doi=10.1007/BF00731863 |s2cid=23508679 |doi-access=free }}
- {{cite journal |vauthors=Matoba R, Okubo K, Hori N, etal |title=The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression. |journal=Gene |volume=146 |issue= 2 |pages= 199–207 |year= 1994 |pmid= 8076819 |doi=10.1016/0378-1119(94)90293-3 }}
- {{cite journal |vauthors=Nakamura T, Board PG, Matsushita K, etal |title=Alpha 1-acid glycoprotein expression in human leukocytes: possible correlation between alpha 1-acid glycoprotein and inflammatory cytokines in rheumatoid arthritis. |journal=Inflammation |volume=17 |issue= 1 |pages= 33–45 |year= 1993 |pmid= 8432561 |doi=10.1007/BF00916390 |hdl=2027.42/44509 |s2cid=6012698 |url=https://deepblue.lib.umich.edu/bitstream/2027.42/44509/1/10753_2004_Article_BF00916390.pdf |hdl-access=free }}
- {{cite journal |vauthors=Yuasa I, Umetsu K, Vogt U, etal |title=Human orosomucoid polymorphism: molecular basis of the three common ORM1 alleles, ORM1*F1, ORM1*F2, and ORM1*S. |journal=Hum. Genet. |volume=99 |issue= 3 |pages= 393–8 |year= 1997 |pmid= 9050929 |doi=10.1007/s004390050378 |s2cid=21298011 }}
- {{cite journal |vauthors=Morin D, Simon N, Deprés-Brummer P, etal |title=Melatonin high-affinity binding to alpha-1-acid glycoprotein in human serum. |journal=Pharmacology |volume=54 |issue= 5 |pages= 271–5 |year= 1997 |pmid= 9380773 |doi=10.1159/000139495 }}
- {{cite journal |vauthors=Nakamura H, Yuasa I, Umetsu K, etal |title=The rearrangement of the human alpha(1)-acid glycoprotein/orosomucoid gene: evidence for tandemly triplicated genes consisting of two AGP1 and one AGP2. |journal=Biochem. Biophys. Res. Commun. |volume=276 |issue= 2 |pages= 779–84 |year= 2000 |pmid= 11027547 |doi= 10.1006/bbrc.2000.3522 }}
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