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OSBPL1A

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

Oxysterol-binding protein-related protein 1 is a protein that in humans is encoded by the OSBPL1A gene.{{cite journal | vauthors = Xu Y, Liu Y, Ridgway ND, McMaster CR | title = Novel members of the human oxysterol-binding protein family bind phospholipids and regulate vesicle transport | journal = J Biol Chem | volume = 276 | issue = 21 | pages = 18407–14 |date=May 2001 | pmid = 11279184 | doi = 10.1074/jbc.M101204200 | doi-access = free }}{{cite journal | vauthors = Laitinen S, Olkkonen VM, Ehnholm C, Ikonen E | title = Family of human oxysterol binding protein (OSBP) homologues. A novel member implicated in brain sterol metabolism | journal = J Lipid Res | volume = 40 | issue = 12 | pages = 2204–11 |date=Feb 2000 | doi = 10.1016/S0022-2275(20)32095-2 | pmid = 10588946 | doi-access = free }}{{cite web | title = Entrez Gene: OSBPL1A oxysterol binding protein-like 1A| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=114876}}

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although some members contain only the sterol-binding domain. Transcript variants derived from alternative promoter usage and/or alternative splicing exist; they encode different isoforms.{{cite web | title = Entrez Gene: OSBPL1A oxysterol binding protein-like 1A| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=114876}}

References

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Further reading

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  • {{cite journal |vauthors=Lehto M, Laitinen S, Chinetti G, etal |title=The OSBP-related protein family in humans. |journal=J. Lipid Res. |volume=42 |issue= 8 |pages= 1203–13 |year= 2001 |doi=10.1016/S0022-2275(20)31570-4 |pmid= 11483621 |doi-access=free }}
  • {{cite journal |vauthors=Jaworski CJ, Moreira E, Li A, etal |title=A family of 12 human genes containing oxysterol-binding domains. |journal=Genomics |volume=78 |issue= 3 |pages= 185–96 |year= 2002 |pmid= 11735225 |doi= 10.1006/geno.2001.6663 |url=https://zenodo.org/record/1229818 }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal |vauthors=Johansson M, Bocher V, Lehto M, etal |title=The two variants of oxysterol binding protein-related protein-1 display different tissue expression patterns, have different intracellular localization, and are functionally distinct. |journal=Mol. Biol. Cell |volume=14 |issue= 3 |pages= 903–15 |year= 2004 |pmid= 12631712 |doi= 10.1091/mbc.E02-08-0459 | pmc=151568 }}
  • {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
  • {{cite journal |vauthors=Johansson M, Lehto M, Tanhuanpää K, etal |title=The oxysterol-binding protein homologue ORP1L interacts with Rab7 and alters functional properties of late endocytic compartments. |journal=Mol. Biol. Cell |volume=16 |issue= 12 |pages= 5480–92 |year= 2006 |pmid= 16176980 |doi= 10.1091/mbc.E05-03-0189 | pmc=1289395 }}
  • {{cite journal |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |s2cid=7827573 |doi-access=free }}

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