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OSBPL2

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

Oxysterol-binding protein-related protein 2 is a protein that in humans is encoded by the OSBPL2 gene.{{cite journal | vauthors = Laitinen S, Olkkonen VM, Ehnholm C, Ikonen E | title = Family of human oxysterol binding protein (OSBP) homologues. A novel member implicated in brain sterol metabolism | journal = J Lipid Res | volume = 40 | issue = 12 | pages = 2204–11 |date=Feb 2000 | doi = 10.1016/S0022-2275(20)32095-2 | pmid = 10588946 | doi-access = free }}{{cite journal | vauthors = Laitinen S, Lehto M, Lehtonen S, Hyvarinen K, Heino S, Lehtonen E, Ehnholm C, Ikonen E, Olkkonen VM | title = ORP2, a homolog of oxysterol binding protein, regulates cellular cholesterol metabolism | journal = J Lipid Res | volume = 43 | issue = 2 | pages = 245–55 |date=Feb 2002 | doi = 10.1016/S0022-2275(20)30166-8 | pmid = 11861666 | doi-access = free }}{{cite web | title = Entrez Gene: OSBPL2 oxysterol binding protein-like 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9885}}

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although some members contain only the sterol-binding domain. This encoded protein contains only the sterol-binding domain. In vitro studies have shown that the encoded protein can bind strongly to phosphatic acid and weakly to phosphatidylinositol 3-phosphate, but cannot bind to 25-hydroxycholesterol. The protein associates with the Golgi apparatus. Transcript variants encoding different isoforms have been described.{{cite web | title = Entrez Gene: OSBPL2 oxysterol binding protein-like 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9885}}

References

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Further reading

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  • {{cite journal |vauthors=Nagase T, Ishikawa K, Suyama M, etal |title=Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 5 |pages= 277–86 |year= 1999 |pmid= 9872452 |doi=10.1093/dnares/5.5.277 |doi-access=free }}
  • {{cite journal | vauthors=Xu Y, Liu Y, Ridgway ND, McMaster CR |title=Novel members of the human oxysterol-binding protein family bind phospholipids and regulate vesicle transport. |journal=J. Biol. Chem. |volume=276 |issue= 21 |pages= 18407–14 |year= 2001 |pmid= 11279184 |doi= 10.1074/jbc.M101204200 |doi-access= free }}
  • {{cite journal |vauthors=Lehto M, Laitinen S, Chinetti G, etal |title=The OSBP-related protein family in humans. |journal=J. Lipid Res. |volume=42 |issue= 8 |pages= 1203–13 |year= 2001 |doi=10.1016/S0022-2275(20)31570-4 |pmid= 11483621 |doi-access=free }}
  • {{cite journal |vauthors=Jaworski CJ, Moreira E, Li A, etal |title=A family of 12 human genes containing oxysterol-binding domains. |journal=Genomics |volume=78 |issue= 3 |pages= 185–96 |year= 2002 |pmid= 11735225 |doi= 10.1006/geno.2001.6663 |url= https://zenodo.org/record/1229818 }}
  • {{cite journal |vauthors=Deloukas P, Matthews LH, Ashurst J, etal |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a |bibcode=2001Natur.414..865D |doi-access= free }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}

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