OSTbeta

OST-beta together with OST-alpha is able to transport estrone sulfate, taurocholate, digoxin, and prostaglandin E2 across cell membranes.{{cite journal |vauthors=Dawson PA, Hubbert M, Haywood J, Craddock AL, Zerangue N, Christian WV, Ballatori N | title = The Heteromeric Organic Solute Transporter α-β, Ostα-Ostβ, Is an Ileal Basolateral Bile Acid Transporter | journal = J. Biol. Chem. | volume = 280 | issue = 8 | pages = 6960–8 |date=February 2005 | pmid = 15563450 | pmc = 1224727 | doi = 10.1074/jbc.M412752200 | doi-access = free }} The Ost-alpha / Ost-beta heterodimer, but not the individual subunits, stimulates sodium-independent bile acid uptake. The heterodimer furthermore is essential for intestinal bile acid transport.{{cite journal |vauthors=Rao A, Haywood J, Craddock AL, Belinsky MG, Kruh GD, Dawson PA | title = The organic solute transporter α-β, Ostα-Ostβ, is essential for intestinal bile acid transport and homeostasis | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 105 | issue = 10 | pages = 3891–6 |date=March 2008 | pmid = 18292224 | pmc = 2268840 | doi = 10.1073/pnas.0712328105 | bibcode = 2008PNAS..105.3891R | doi-access = free }}

OST-alpha and OST-beta have high expression in the testis, colon, liver, small intestine, kidney, ovary, and adrenal gland.

• OSTalpha
• OST Family
• Transporter Classification Database

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• {{cite journal | author=Sun AQ |title=Protein-protein interactions and membrane localization of the human organic solute transporter |journal=Am. J. Physiol. Gastrointest. Liver Physiol. |volume=292 |issue= 6 |pages= G1586–93 |year= 2007 |pmid= 17332473 |doi= 10.1152/ajpgi.00457.2006 |name-list-style=vanc| author2=Balasubramaniyan N | author3=Xu K | display-authors=3 | last4=Liu | first4=C. J. | last5=Ponamgi | first5=V. M. | last6=Liu | first6=H. | last7=Suchy | first7=F. J. }}
• {{cite journal | author=Boyer JL |title=Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTalpha-OSTbeta in cholestasis in humans and rodents |journal=Am. J. Physiol. Gastrointest. Liver Physiol. |volume=290 |issue= 6 |pages= G1124–30 |year= 2006 |pmid= 16423920 |doi= 10.1152/ajpgi.00539.2005 |name-list-style=vanc| author2=Trauner M | author3=Mennone A | display-authors=3 | last4=Soroka | first4=CJ | last5=Cai | first5=SY | last6=Moustafa | first6=T | last7=Zollner | first7=G | last8=Lee | first8=JY | last9=Ballatori | first9=N |s2cid=86156271 }}
• {{cite journal | author=Ballatori N |title=OSTalpha-OSTbeta: a major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia |journal=Hepatology |volume=42 |issue= 6 |pages= 1270–9 |year= 2005 |pmid= 16317684 |doi= 10.1002/hep.20961 |name-list-style=vanc| author2=Christian WV | author3=Lee JY | display-authors=3 | last4=Dawson | first4=Paul A. | last5=Soroka | first5=Carol J. | last6=Boyer | first6=James L. | last7=Madejczyk | first7=Michael S. | last8=Li | first8=Na | doi-access=free }}
• {{cite journal |vauthors=Landrier JF, Eloranta JJ, Vavricka SR, Kullak-Ublick GA |title=The nuclear receptor for bile acids, FXR, transactivates human organic solute transporter-alpha and -beta genes |journal=Am. J. Physiol. Gastrointest. Liver Physiol. |volume=290 |issue= 3 |pages= G476–85 |year= 2006 |pmid= 16269519 |doi= 10.1152/ajpgi.00430.2005 |s2cid=8687386 }}
• {{cite journal | author=Lee H |title=FXR regulates organic solute transporters alpha and beta in the adrenal gland, kidney, and intestine |journal=J. Lipid Res. |volume=47 |issue= 1 |pages= 201–14 |year= 2006 |pmid= 16251721 |doi= 10.1194/jlr.M500417-JLR200 |name-list-style=vanc| author2=Zhang Y | author3=Lee FY | display-authors=3 | last4=Nelson | first4=SF | last5=Gonzalez | first5=FJ | last6=Edwards | first6=PA | doi-access=free}}
• {{cite journal | author=Dawson PA |title=The Heteromeric Organic Solute Transporter α-β, Ostα-Ostβ, Is an Ileal Basolateral Bile Acid Transporter |journal=J. Biol. Chem. |volume=280 |issue= 8 |pages= 6960–8 |year= 2005 |pmid= 15563450 |doi= 10.1074/jbc.M412752200 | pmc=1224727 |name-list-style=vanc| author2=Hubbert M | author3=Haywood J | display-authors=3 | last4=Craddock | first4=AL | last5=Zerangue | first5=N | last6=Christian | first6=WV | last7=Ballatori | first7=N |doi-access=free }}
• {{cite journal |vauthors=Seward DJ, Koh AS, Boyer JL, Ballatori N |title=Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta |journal=J. Biol. Chem. |volume=278 |issue= 30 |pages= 27473–82 |year= 2003 |pmid= 12719432 |doi= 10.1074/jbc.M301106200 |doi-access= free }}
• {{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-style=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }}

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