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OTUB2

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

Ubiquitin thioesterase OTUB2 is an enzyme that in humans is encoded by the OTUB2 gene.{{cite journal | vauthors = Balakirev MY, Tcherniuk SO, Jaquinod M, Chroboczek J | title = Otubains: a new family of cysteine proteases in the ubiquitin pathway | journal = EMBO Rep | volume = 4 | issue = 5 | pages = 517–22 |date=Apr 2003 | pmid = 12704427 | pmc = 1319179 | doi = 10.1038/sj.embor.embor824 }}{{cite web | title = Entrez Gene: OTUB2 OTU domain, ubiquitin aldehyde binding 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=78990| accessdate = }}

Otubains are deubiquitinating cysteine proteases (DUBs; see MIM 602519) that belong to the ovarian tumor (OTU) protein superfamily. Like other DUBs, otubains cleave proteins precisely at the ubiquitin (UB; see MIM 191339)-protein bond.{{cite web | title = Entrez Gene: OTUB2 OTU domain, ubiquitin aldehyde binding 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=78990| accessdate = }}

References

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Further reading

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  • {{cite journal |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R |s2cid=4427026 }}
  • {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
  • {{cite journal |vauthors=Nanao MH, Tcherniuk SO, Chroboczek J, etal |title=Crystal structure of human otubain 2. |journal=EMBO Rep. |volume=5 |issue= 8 |pages= 783–8 |year= 2005 |pmid= 15258613 |doi= 10.1038/sj.embor.7400201 | pmc=1299112 }}
  • {{cite journal |vauthors=Namciu SJ, Friedman RD, Marsden MD, etal |title=Sequence organization and matrix attachment regions of the human serine protease inhibitor gene cluster at 14q32.1. |journal=Mamm. Genome |volume=15 |issue= 3 |pages= 162–78 |year= 2004 |pmid= 15014966 |doi= 10.1007/s00335-003-2311-y |s2cid=8594824 }}
  • {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
  • {{cite journal |vauthors=Heilig R, Eckenberg R, Petit JL, etal |title=The DNA sequence and analysis of human chromosome 14. |journal=Nature |volume=421 |issue= 6923 |pages= 601–7 |year= 2003 |pmid= 12508121 |doi= 10.1038/nature01348 |bibcode=2003Natur.421..601H |doi-access= free }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}

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