OXSR1
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Serine/threonine-protein kinase OSR1 is an enzyme that in humans is encoded by the OXSR1 gene.{{cite journal | vauthors = Tamari M, Daigo Y, Nakamura Y | title = Isolation and characterization of a novel serine threonine kinase gene on chromosome 3p22-21.3 | journal = J Hum Genet | volume = 44 | issue = 2 | pages = 116–20 |date=Apr 1999 | pmid = 10083736 | doi = 10.1007/s100380050121 | doi-access = free }}{{cite web | title = Entrez Gene: OXSR1 oxidative-stress responsive 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9943}}
The product of this gene belongs to the Ser/Thr protein kinase family of proteins. It regulates downstream kinases in response to environmental stress, and may play a role in regulating the actin cytoskeleton.
References
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Further reading
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- {{cite journal |vauthors=Daigo Y, Isomura M, Nishiwaki T, etal |title=Characterization of a 1200-kb genomic segment of chromosome 3p22-p21.3. |journal=DNA Res. |volume=6 |issue= 1 |pages= 37–44 |year= 1999 |pmid= 10231028 |doi=10.1093/dnares/6.1.37 |doi-access=free }}
- {{cite journal |vauthors=Kikuno R, Nagase T, Ishikawa K, etal |title=Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=6 |issue= 3 |pages= 197–205 |year= 1999 |pmid= 10470851 |doi=10.1093/dnares/6.3.197 |doi-access=free }}
- {{cite journal | vauthors=Piechotta K, Lu J, Delpire E |title=Cation chloride cotransporters interact with the stress-related kinases Ste20-related proline-alanine-rich kinase (SPAK) and oxidative stress response 1 (OSR1). |journal=J. Biol. Chem. |volume=277 |issue= 52 |pages= 50812–9 |year= 2003 |pmid= 12386165 |doi= 10.1074/jbc.M208108200 |doi-access= free }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal | vauthors=Chen W, Yazicioglu M, Cobb MH |title=Characterization of OSR1, a member of the mammalian Ste20p/germinal center kinase subfamily. |journal=J. Biol. Chem. |volume=279 |issue= 12 |pages= 11129–36 |year= 2004 |pmid= 14707132 |doi= 10.1074/jbc.M313562200 |doi-access= free }}
- {{cite journal |vauthors=Beausoleil SA, Jedrychowski M, Schwartz D, etal |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446 |bibcode=2004PNAS..10112130B |doi-access=free }}
- {{cite journal |vauthors=Ballif BA, Villén J, Beausoleil SA, etal |title=Phosphoproteomic analysis of the developing mouse brain. |journal=Mol. Cell. Proteomics |volume=3 |issue= 11 |pages= 1093–101 |year= 2005 |pmid= 15345747 |doi= 10.1074/mcp.M400085-MCP200 |doi-access= free }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Barrios-Rodiles M, Brown KR, Ozdamar B, etal |title=High-throughput mapping of a dynamic signaling network in mammalian cells. |journal=Science |volume=307 |issue= 5715 |pages= 1621–5 |year= 2005 |pmid= 15761153 |doi= 10.1126/science.1105776 |bibcode=2005Sci...307.1621B |s2cid=39457788 }}
- {{cite journal |vauthors=Moriguchi T, Urushiyama S, Hisamoto N, etal |title=WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1. |journal=J. Biol. Chem. |volume=280 |issue= 52 |pages= 42685–93 |year= 2006 |pmid= 16263722 |doi= 10.1074/jbc.M510042200 |doi-access= free }}
- {{cite journal |vauthors=Cusick JK, Xu LG, Bin LH, etal |title=Identification of RELT homologues that associate with RELT and are phosphorylated by OSR1. |journal=Biochem. Biophys. Res. Commun. |volume=340 |issue= 2 |pages= 535–43 |year= 2006 |pmid= 16389068 |doi= 10.1016/j.bbrc.2005.12.033 }}
- {{cite journal |vauthors=Vitari AC, Thastrup J, Rafiqi FH, etal |title=Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1. |journal=Biochem. J. |volume=397 |issue= 1 |pages= 223–31 |year= 2006 |pmid= 16669787 |doi= 10.1042/BJ20060220 | pmc=1479760 }}
- {{cite journal |vauthors=Anselmo AN, Earnest S, Chen W, etal |title=WNK1 and OSR1 regulate the Na+, K+, 2Cl- cotransporter in HeLa cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 29 |pages= 10883–8 |year= 2006 |pmid= 16832045 |doi= 10.1073/pnas.0604607103 | pmc=1544143 |bibcode=2006PNAS..10310883A |doi-access=free }}
- {{cite journal |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |s2cid=7827573 |doi-access=free }}
- {{cite journal |vauthors=Ewing RM, Chu P, Elisma F, etal |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= 1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 }}
- {{cite journal |vauthors=Villa F, Goebel J, Rafiqi FH, etal |title=Structural insights into the recognition of substrates and activators by the OSR1 kinase. |journal=EMBO Rep. |volume=8 |issue= 9 |pages= 839–45 |year= 2007 |pmid= 17721439 |doi= 10.1038/sj.embor.7401048 | pmc=1973955 }}
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