Onycholysis

• Unknown
• Trauma, excessive manicuring
• Infection: especially fungal
• Skin disease: psoriasis, dermatitis
• Impaired peripheral circulation, e.g. Raynaud's syndrome
• Systemic disease: hyperthyroidism, hypothyroidism, reactive arthritis, porphyria cutanea tarda
• Reaction to detergents (e.g. washing dishes with bare hands, using detergent-based shampoos or soaps).{{Cite journal|last1=Mayon-White|first1=R. T.|last2=Hodgson|first2=G.|date=1971-08-07|title=Acute onychia and onycholysis due to an enzyme detergent.|journal=Br Med J|language=en|volume=3|issue=5770|pages=352|doi=10.1136/bmj.3.5770.352|issn=0007-1447|pmid=5558190|pmc=1798590}}{{Cite journal|last1=Al-Kathiri|first1=Lutfi|last2=Al-Asmaili|first2=Abla|date=2016|title=Diclofenac-Induced Photo-Onycholysis|journal=Oman Medical Journal|volume=31|issue=1|pages=65–68|doi=10.5001/omj.2016.12|issn=1999-768X|pmc=4720947|pmid=26816569}}{{Cite journal|last1=Alevizos|first1=Alevizos|last2=Gregoriou|first2=Stamatis|last3=Larios|first3=George|last4=Rigopoulos|first4=Dimitris|date=2008-02-01|title=Acute and Chronic Paronychia|url=https://www.aafp.org/afp/2008/0201/p339.html|journal=American Family Physician|language=en|volume=77|issue=3|pages=339–346|pmid=18297959|issn=0002-838X}}
• Patients with hepatocellular dysfunction may develop hair-thinning or hair loss and nail changes such as clubbing, leukonychia (whitening), or onycholysis, affecting the nails of the hands and feet.{{cite journal|first1= Ribhi|last1= Hazin|first2= Tarek I. Abu-Rajab|last2= Tamimi|first3= Jamil Y.|last3= Abuzetun|first4= Nizar N.|last4= Zein|title= Recognizing and treating cutaneous signs of liver disease|url= http://www.ccjm.org/content/76/10/599|journal= Cleveland Clinic Journal of Medicine|date= October 2009|issn= 0891-1150|pages= 599–606|volume= 76|issue= 10|doi= 10.3949/ccjm.76A.08113|pmid=19797460|doi-access= free}}
• Onychomycosis (tinea)
• It is common in ballet dancers{{cite web |last1=Shah |first1=Selina |title=Pointe shoes complicate biomechanics of ballet|url=https://lermagazine.com/article/pointe-shoes-complicate-biomechanics-of-balle |website=Lower Extremity Review Magazine |date=April 2010}}
• Chemotherapy (cytotoxic agents like taxanes, vinca alkaloids and others)
• Chronic Renal Failure{{cite journal | last=Niema | first=Aqil | last2=Aicha | first2=Nassiri | last3=Salim | first3=Gallouj | last4=Fatima Zahra | first4=Mernissi | title=Nail Disorders in Patients with Chronic Renal Failure | journal=Journal of Dermatology Research and Therapy | publisher=ClinMed International Library | volume=5 | issue=1 | date=2019-06-30 | issn=2469-5750 | url=https://clinmedjournals.org/articles/ijdrt/journal-of-dermatology-research-and-therapy-ijdrt-5-065.php?jid=ijdrt | page=}}

Most instances of onycholysis without a clear cause will heal spontaneously within a few weeks. The most commonly recommended treatment is to keep the nail dry as much as possible and allow the nail to slowly reattach. Trimming away as much loose nail as can be done comfortably will prevent the nail from being pried upwards. Cleaning under the nail is not recommended as this only serves to separate the nail further. Bandages are also to be avoided.{{cite web|url=http://www.aocd.org/?page=Onycholysis|title=Onycholysis|publisher=American Osteopathic College of Dermatology|access-date=29 December 2016}} When kept dry and away from further trauma, the nail will reattach from the base upward (i.e., from proximal to distal). The aim of treatment is also to eliminate onychomycosis that is a major cause of onycholysis. Antifungals like terbinafin and itraconazole in the form of oral pills should be given for 6 to 8 weeks.

If the underlying cause of the condition is not found and the nail continues to detach despite conservative treatment, the nail bed may begin to form a granular layer of abnormal cells on its surface. After six months of detachment, this layer is likely to prevent the adhesion of any new nail tissue, possibly leading to permanent deformity.{{cite web|url=http://www.nailsmag.com/article/91567/the-nail-doctor-onycholysis-or-nail-separation-has-different-varieties|title=The Nail Doctor: Onycholysis, or Nail Separation, Has Different Varieties|author=Richard K. Scherr|date=1 December 1997|publisher=Nails Magazine}}

The word onycholysis comes from onycho-, from Ancient Greek ὄνυξ ónuks 'nail', and Ancient Greek λύσις lúsis 'lysis/disintegration'.{{Cite web |last=Services |first=ProZ com Translation |title=lusis {{!}} Greek (Ancient) to English {{!}} Poetry & Literature |url=https://www.proz.com/kudoz/greek-ancient-to-english/poetry-literature/644733-lusis.html |access-date=2022-10-08 |website=ProZ.com {{!}} Freelance translators and interpreters |language=en}}

• List of cutaneous conditions
• Plummer's nail

{{Reflist}}

{{Medical resources

| DiseasesDB = 9236

| ICD10 = {{ICD10|L|60|1|l}}

| ICD9 = {{ICD9|703.8}}

| ICDO =

| OMIM =

| MedlinePlus =

| eMedicineSubj =

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| MeshID = D054039

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Category:Conditions of the skin appendages