Opioidergic
{{Short description|Classification of chemicals that directly modulate opioid neuropeptide systems}}
File:Correlación estructural entre las encefalinas y la morfina.svg, an opioid peptide, (left) and morphine, an opiate drug, (right)]]
An opioidergic agent (or drug) is a chemical which directly or indirectly modulate the function of opioid receptors. Opioidergics comprise opioids, as well as allosteric modulators and enzyme affecting agents like enkephalinase inhibitors.
Allosteric modulators
- BMS-986121: μ-PAM{{cite journal |vauthors=Burford NT, Clark MJ, Wehrman TS, etal |title=Discovery of positive allosteric modulators and silent allosteric modulators of the μ-opioid receptor |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=110 |issue=26 |pages=10830–5 |date=June 2013 |pmid=23754417 |pmc=3696790 |doi=10.1073/pnas.1300393110 |bibcode=2013PNAS..11010830B |doi-access=free }}
- BMS-986122: μ-PAM
- BPRMU191: confers agonistic properties to small-molecule morphinan antagonists{{cite journal |vauthors=Huang YH, Lin SY, Ou LC et al. |title=Discovery of a mu-opioid receptor modulator that in combination with morphinan antagonists induces analgesia |journal=Cell Chem Biol |volume=31 |issue=11 |pages=1885–1898.e10 |date=2024 |pmid=39025070 |doi=10.1016/j.chembiol.2024.06.013 |url=}}
- Ignavine{{cite journal |vauthors=Ohbuchi K, Miyagi C, Suzuki Y, Mizuhara Y, Mizuno K, Omiya Y, Yamamoto M, Warabi E, Sudo Y, Yokoyama A, Miyano K, Hirokawa T, Uezono Y |title=Ignavine: a novel allosteric modulator of the μ opioid receptor |journal=Sci Rep |volume=6 |pages=31748 |date=August 2016 |pmid=27530869 |pmc=4987652 |doi=10.1038/srep31748 |bibcode=2016NatSR...631748O }}
- Oxytocin: μ-PAM{{cite journal |vauthors=Meguro Y, Miyano K, Hirayama S, et al |title=Neuropeptide oxytocin enhances μ opioid receptor signaling as a positive allosteric modulator |journal=J. Pharmacol. Sci. |volume=137 |issue=1 |pages=67–75 |date=May 2018 |pmid=29716811 |doi=10.1016/j.jphs.2018.04.002 |doi-access=free }}
- δ-PAM (see reference){{cite journal |vauthors=Burford NT, Livingston KE, Canals M, Ryan MR, Budenholzer LM, Han Y, Shang Y, Herbst JJ, O'Connell J, Banks M, Zhang L, Filizola M, Bassoni DL, Wehrman TS, Christopoulos A, Traynor JR, Gerritz SW, Alt A |title=Discovery, Synthesis, and Molecular Pharmacology of Selective Positive Allosteric Modulators of the δ-Opioid Receptor |journal=J. Med. Chem. |volume= 58|issue= 10|pages= 4220–9|year=2015 |pmid=25901762 |doi=10.1021/acs.jmedchem.5b00007 |pmc=4703104}}
- Cannabidiol{{cite journal |vauthors=Kathmann M, Flau K, Redmer A, Tränkle C, Schlicker E | title = Cannabidiol is an allosteric modulator at mu- and delta-opioid receptors | journal = Naunyn-Schmiedeberg's Arch. Pharmacol. | volume = 372 | issue = 5 | pages = 354–61 | date = February 2006 | pmid = 16489449 | doi = 10.1007/s00210-006-0033-x | s2cid = 4877869 }}
- Tetrahydrocannabinol
- Sodium (Na+) {{cite journal |vauthors=Shang Y, LeRouzic V, Schneider S, Bisignano P, Pasternak GW, Filizola M |title=Mechanistic insights into the allosteric modulation of opioid receptors by sodium ions |journal=Biochemistry |volume=53 |issue=31 |pages=5140–9 |year=2014 |pmid=25073009 |doi=10.1021/bi5006915 |pmc=4131901}}
See also
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- List of opioids
- Adenosinergic
- Adrenergic
- Cannabinoidergic
- Cholinergic
- Dopaminergic
- GABAergic
- Glycinergic
- Histaminergic
- Melatonergic
- Monoaminergic
- Serotonergic
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References
{{Reflist|2}}
{{Opioidergics}}
{{Neuromodulation}}
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