Organification

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Organification is a biochemical process that takes place in the thyroid gland. It is the incorporation of iodine into thyroglobulin for the production of thyroid hormone, a step done after the oxidation of iodide by the enzyme thyroid peroxidase (TPO){{cite book | vauthors = Shargel L, Mutnick AH, Souney PF |title=Comprehensive Pharmacy Review |date=May 2007 |publisher=Lippincott Williams and Wilkins |isbn=978-0-7817-7403-1 |pages=1181}}

Since iodine is an inorganic compound, and is being attached to thyroglobulin, a protein, the process is termed as "organification of iodine".{{cite book | vauthors = Molinam PE, Ashman R | author-link1 = Patricia E. Molina |title=Endocrine Physiology |publisher=McGraw Hill Professional |isbn=978-0-07-161302-6 |pages=81 |edition=Third}}

Thionamides can block organification.{{cite book | chapter = Thionamides |date= January 2016 |chapter-url= https://www.sciencedirect.com/science/article/pii/B9780444537171015377| title = Meyler's Side Effects of Drugs (Sixteenth Edition)|pages=874–889| veditors = Aronson JK |place=Oxford|publisher=Elsevier|language=en|doi=10.1016/b978-0-444-53717-1.01537-7|isbn=978-0-444-53716-4|access-date=2021-02-18}}