Orly Alter

Alter began attending school at Tel Aviv University in Israel and graduated in October 1989 magna cum laude with her bachelors of science in physics. After receiving her undergraduate degree, she began pursuing her Ph.D. in applied physics at the Stanford University in California, USA. She completed her Ph.D. with a thesis on “Impossibility of Determining the Quantum Wavefunction of a Single System and a Fundamental Limit to External Force Detection," under the mentorship of Yoshihisa Yamamoto in January 1999{{Cite thesis |title=Impossibility of determining the quantum wavefunction of a single system and a fundamental limit to external force detection |url=https://searchworks.stanford.edu/view/4028357 |date=1999 |first=Orly |last=Alter}} and then moved onto a postdoctoral fellowship in genetics, remaining at Stanford.{{Cite web |title=Alfred P. Sloan Foundation 1999 Annual Report |url=https://sloan.org/storage/app/media/files/annual_reports/1999_annual_report.pdf |access-date=2025-02-05 |website=sloan.org}} Alter moved to the University of Utah in 2010, where she joined the Scientific Computing and Imaging Institute as a USTAR Associate Professor of Bioengineering.{{Cite web |title=Orly Alter Joins the Scientific Computing and Imaging Institute as a USTAR Associate Professor of Bioengineering |url=https://www.sci.utah.edu/the-institute/news/329-orly-ustar.html |access-date=2024-05-24 |website=www.sci.utah.edu}}

Following this, she became a member of Cancer Control and Population Sciences Program, and was co-founder and Chief Scientific Officer of Prism AI Therapeutics in 2024.{{cite web |last1=Alter |first1=Orly |title=Orly Alter – Curriculum Vitae |url=https://alterlab.org/orly/CV.html |website=alterlab.org}}

Alter has one published book named Quantum Measurement of a Single System,{{Cite book |last=Alter |first=Orly |title=Quantum Measurement of a Single System |publisher=Wiley |isbn=978-3527617128}}{{cite web |last1=Donald |first1=Matthew J. |title=Book Review - Quantum Measurement of a Single System by Orly Alter and Yoshihisa Yamamoto |url=https://people.bss.phy.cam.ac.uk/~mjd1014/qmss.pdf |website=people.bss.phy.cam.ac.uk |access-date=8 March 2025 |date=February 2002}} co-authored with Yamamoto, and another book in preparation, Genomic Signal Processing: Discovery of Principles of Nature from Matrix and Tensor Modeling of Large-Scale Molecular Biological Data.{{Cite book |last=Alter |first=Orly |title=Genomic Signal Processing: Discovery of Principles of Nature from Matrix and Tensor Modeling |publisher=Wiley |isbn=978-1119078371}} Alter's work on finding patterns in DNA finds predictors indicative of a woman's risk for ovarian cancer,{{Cite news |date=February 2016 |title=Increasing Accuracy of Diagnosis, Prognosis |work=USA Today; Farmingdale |pages=8 |via=Proquest |volume=144 |issue=2849}} and she uses mathematical models to improve the outcomes for women with ovarian cancer.{{Cite news |date=15 Apr 2015 |title=U. researchers' mathematical models could provide better ovarian cancer treatment, outcomes |work=The Salt Lake Tribune; Salt Lake City, Utah |via=Proquest}}{{cite web |title=Big Data, Hidden Knowledge |url=https://thepathologist.com/issues/2015/articles/jun/big-data-hidden-knowledge/ |website=The Pathologist |publisher=Texere Publishing |access-date=12 March 2025 |language=en |date=15 June 2015}}{{cite web |title=Calculating Cancer Cures |url=https://nae.edu/File.aspx?id=134900&File.mp3 |website=National Academy of Engineering (NAE) Innovation Podcast and Radio Series |publisher=NAE in Collaboration with WTOP Radio |access-date=12 March 2025 |language=en |date=19 April 2019}}

Alter's team identified a DNA pattern as a predictor of survival in glioblastoma patients using new mathematical methods, which was reported in 2020.{{cite web |title=Genome-wide pattern found in tumors from brain cancer patients predicts life expectancy |url=https://www.eurekalert.org/news-releases/477030 |website=EurekAlert! |publisher=University of Utah Health |access-date=8 March 2025 |language=en |date=15 May 2020}}

In 2005 Alter was selected by the International Linear Algebra Society to give the Linear Algebra and its Applications Lecture.{{Cite web |title=LAA-lecturers |url=https://ilasic.org/laa-lecturers/ |access-date=2024-05-24 |website=International Linear Algebra Society |language=en-US}}{{cite magazine |last1=Alter |first1=Orly |title=Genomic Signal Processing: From Matrix Algebra to Genetic Networks |editor1-last=Shader |editor1-first=Bryan L. |journal=The Bulletin of the International Linear Algebra Society |date=Fall 2005 |issue=35 |pages=2–14 |url=https://ilasic.org/wp-content/uploads/IMAGE/image35.pdf}} Alter was an American Association of Physicists in Medicine Science Council Session Winner in 2014.{{cite web |title=AAPM Science Council Session Winner (SCSW) Recipients |url=https://aapm.org/org/history/SCSessionWinners.asp |website=aapm.org |access-date=8 March 2025}}

• {{Cite journal |last1=Alter |first1=Orly |last2=Brown |first2=Patrick O. |last3=Botstein |first3=David |date=2000-08-29 |title=Singular value decomposition for genome-wide expression data processing and modeling |journal=Proceedings of the National Academy of Sciences |language=en |volume=97 |issue=18 |pages=10101–10106 |bibcode=2000PNAS...9710101A |doi=10.1073/pnas.97.18.10101 |issn=0027-8424 |pmc=27718 |pmid=10963673 |doi-access=free}}
• {{Cite journal |last1=Alter |first1=Orly |last2=Brown |first2=Patrick O. |last3=Botstein |first3=David |date=2003-03-18 |title=Generalized singular value decomposition for comparative analysis of genome-scale expression data sets of two different organisms |journal=Proceedings of the National Academy of Sciences |language=en |volume=100 |issue=6 |pages=3351–3356 |bibcode=2003PNAS..100.3351A |doi=10.1073/pnas.0530258100 |issn=0027-8424 |pmc=152296 |pmid=12631705 |doi-access=free}}
• {{Cite journal |last1=Omberg |first1=Larsson |last2=Golub |first2=Gene H. |last3=Alter |first3=Orly |date=2007-11-20 |title=A tensor higher-order singular value decomposition for integrative analysis of DNA microarray data from different studies |journal=Proceedings of the National Academy of Sciences |language=en |volume=104 |issue=47 |pages=18371–18376 |bibcode=2007PNAS..10418371O |doi=10.1073/pnas.0709146104 |issn=0027-8424 |pmc=2147680 |pmid=18003902 |doi-access=free}}
• {{Cite book |last=Alter |first=Orly |title=Genomic Signal Processing: Discovery of Principles of Nature from Matrix and Tensor Modeling |publisher=Wiley |isbn=978-1-119-07837-1 |language=English}}

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Category:Living people

Category:University of Utah faculty

Category:Tel Aviv University alumni

Category:Stanford University alumni

Category:Geneticists

Category:Women physicists