Ornipressin

{{chembox

| verifiedrevid = 444142540

| ImageFile=Ornipressin.png

| ImageSize=

| IUPACName=(2S)-N-[(2S)-5-Amino-1-[(2-amino-2-oxoethyl)amino]- 1-oxopentan-2-yl]-1-[(4R,7S,10S,13S,16S,19R)- 19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-16-[(4-hydroxyphenyl)methyl] -6,9,12,15,18-pentaoxo-13-(phenylmethyl)1,2-dithia-5,8,11,14,17- pentazacycloicosane-4-carbonyl]pyrrolidine-2-carboxamide

| OtherNames=

|Section1={{Chembox Identifiers

| UNII_Ref = {{fdacite|correct|FDA}}

| UNII = 1KTH6N080W

| InChI = 1/C45H63N13O12S2/c46-16-4-8-28(39(64)51-21-37(50)62)53-44(69)34-9-5-17-58(34)45(70)33-23-72-71-22-27(47)38(63)54-30(19-25-10-12-26(59)13-11-25)42(67)55-31(18-24-6-2-1-3-7-24)41(66)52-29(14-15-35(48)60)40(65)56-32(20-36(49)61)43(68)57-33/h1-3,6-7,10-13,27-34,59H,4-5,8-9,14-23,46-47H2,(H2,48,60)(H2,49,61)(H2,50,62)(H,51,64)(H,52,66)(H,53,69)(H,54,63)(H,55,67)(H,56,65)(H,57,68)/t27-,28-,29-,30-,31-,32-,33-,34-/m0/s1

| InChIKey = MUNMIGOEDGHVLE-LGYYRGKSBZ

| StdInChI_Ref = {{stdinchicite|correct|chemspider}}

| StdInChI = 1S/C45H63N13O12S2/c46-16-4-8-28(39(64)51-21-37(50)62)53-44(69)34-9-5-17-58(34)45(70)33-23-72-71-22-27(47)38(63)54-30(19-25-10-12-26(59)13-11-25)42(67)55-31(18-24-6-2-1-3-7-24)41(66)52-29(14-15-35(48)60)40(65)56-32(20-36(49)61)43(68)57-33/h1-3,6-7,10-13,27-34,59H,4-5,8-9,14-23,46-47H2,(H2,48,60)(H2,49,61)(H2,50,62)(H,51,64)(H,52,66)(H,53,69)(H,54,63)(H,55,67)(H,56,65)(H,57,68)/t27-,28-,29-,30-,31-,32-,33-,34-/m0/s1

| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}

| StdInChIKey = MUNMIGOEDGHVLE-LGYYRGKSSA-N

| CASNo_Ref = {{cascite|correct|??}}

| CASNo=3397-23-7

| PubChem=14257660

| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}

| ChemSpiderID=16736525

| MeSHName=Ornipressin

| SMILES = NC(=O)CNC(=O)[C@H](CCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H]4NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@@H](N)CSSC4)CC(N)=O

}}

|Section2={{Chembox Properties

| Formula=C45H63N13O12S2

| MolarMass=1042.19 g/mol

| Appearance=

| Density=

| MeltingPt=

| BoilingPt=

| Solubility=

}}

|Section6={{Chembox Pharmacology

| ATCCode_prefix = H01

| ATCCode_suffix = BA05

}}

|Section7={{Chembox Hazards

| MainHazards=

| FlashPt=

| AutoignitionPt =

}}

}}

Ornipressin is a vasoconstrictor,{{cite journal |title=Dose-response relation of ornipressin with regard to vasoconstriction in human skin |author=H. Fruhstofer, M.D., M. Heisler, M.D. |journal=Br. J. Anaesth. |year=1994 |volume=73 |issue=2 |pages=220–224 |doi=10.1093/bja/73.2.220 |pmid=7917739 |doi-access=free }}{{cite journal |title=Ornipressin (Por 8): An Efficient Alternative to Counteract Hypotension During Combined General/Epidural Anesthesia |author=Marc De Kock, MD, Pierre-Francois Laterre, MD, Patricia Andruetto, MD, Lionel Vanderessen, MD, Sylvie Dekrom, MD, Bernard Vanderick, MD and Patricia Lavand’homme, MD |journal=Anesthesia & Analgesia |date=June 2000 |volume=90 |issue=6 |pages=1301–1307 |url=http://www.anesthesia-analgesia.org/content/90/6/1301.short |doi=10.1097/00000539-200006000-00008|pmid=10825311 |s2cid=44936158 |doi-access=free }} haemostatic and renal agent.

References

{{Reflist|2}}

{{Oxytocin and vasopressin receptor modulators}}

Category:Peptides

Category:Vasopressin receptor agonists

Category:Antidiuretics

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