Otsquene Creek
{{Use American English|date=February 2025}}
{{Infobox river
| name = Otsquene Creek
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| pushpin_map = New York Adirondack Park#USA
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| pushpin_map_caption= Location of the mouth of Otsquene Creek
| subdivision_type1 = Country
| subdivision_name1 = United States
| subdivision_type2 = State
| subdivision_name2 = New York
| subdivision_type3 = Region
| subdivision_name3 = Central New York Region
| subdivision_type4 = Counties
| subdivision_name4 = Herkimer, Montgomery
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| source1_coordinates= {{coord|42.964384|-74.770851|format=dms}}
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| mouth = Otsquago Creek
| mouth_location = Valley Brook, New York, United States
| mouth_coordinates = {{coord|42.9314400|-74.6722380|display=inline,title|format=dms}}{{cite gnis
| id = 2788145
| name = Otsquene creek
| accessdate = 2017-11-28 }}{{cite web
| url = https://www.dec.ny.gov/docs/water_pdf/wimohawkcanajoharie.pdf&ved=2ahUKEwj3n6GgttXiAhUv1VkKHVfLAWkQFjARegQIARAB&usg=AOvVaw3t8tV86plddaqfz3-XB721
| title = Mohawk/Canajoharie Creek Watershed - New York State Department of Environmental Conservation
| date = 2019
| website = dec.ny.gov
| publisher = dec.ny.gov
| access-date = 6 June 2019
| quote = data}}
| mouth_elevation = {{convert|423|ft|abbr=on}}
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Otsquene Creek is a river in Herkimer County and Montgomery County in the U.S. State of New York. It enters Otsquago Creek by Valley Brook, New York.{{cite web
| url = http://www.dec.ny.gov/docs/water_pdf/wimohawkcanajoharie.pdf#page11
| title = Otsquene Creek
| date = 2002
| website = dec.ny.gov
| publisher = nysdec
| access-date = 3 October 2017
| quote = data}} On the 1905 Fulton and Montgomery County Atlas it is referred to as Crab-skill Creek.