Overall hemostatic potential

{{Short description|Test used to measure blood coagulation}}

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{{Infobox diagnostic

| Name = Overall hemostatic potential

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| test of = Coagulation, hypercoagulability, hypocoagulability, hemostasis, fibrinolysis

| Synonyms = Overall hemostasis potential; Overall haemostasis potential; Overall haemostatic potential; OHP

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The overall hemostatic potential (OHP) test is a global coagulation assay which can be used to measure coagulation.{{cite book | vauthors = Curnow J | title = Hemostasis and Thrombosis | chapter = The Overall Hemostatic Potential (OHP) Assay | series = Methods Mol Biol | volume = 1646 | pages = 523–531 | date = 2017 | pmid = 28804852 | doi = 10.1007/978-1-4939-7196-1_38 | isbn = 978-1-4939-7194-7 | chapter-url = }}{{cite journal | vauthors = Lim HY, Donnan G, Nandurkar H, Ho P | title = Global coagulation assays in hypercoagulable states | journal = J Thromb Thrombolysis | volume = 54| issue = 1| pages = 132–144| date = January 2022 | pmid = 34997471 | doi = 10.1007/s11239-021-02621-1 | s2cid = 245804095 | url = }}{{cite journal | vauthors = Antovic A | title = The overall hemostasis potential: a laboratory tool for the investigation of global hemostasis | journal = Semin Thromb Hemost | volume = 36 | issue = 7 | pages = 772–9 | date = October 2010 | pmid = 20978998 | doi = 10.1055/s-0030-1265294 | s2cid = 35249276 | url = }}{{cite journal | vauthors = Antovic A | title = Screening haemostasis--looking for global assays: the Overall Haemostasis Potential (OHP) method--a possible tool for laboratory investigation of global haemostasis in both hypo- and hypercoagulable conditions | journal = Curr Vasc Pharmacol | volume = 6 | issue = 3 | pages = 173–85 | date = July 2008 | pmid = 18673157 | doi = 10.2174/157016108784912028 | url = }} The OHP assay measures total fibrin generation in the presence of thrombin or tissue factor and tissue plasminogen activator (t-PA). It generates a fibrin time curve through the use of optical density measurement. This curve represents the balance between fibrin formation induced by thrombin or tissue factor and fibrinolysis induced by t-PA. The assay provides three parameters: overall coagulation potential (OCP), overall hemostatic potential (OHP), and overall fibrinolytic potential (OFP). OHP is the main parameter, while OCP and OFP are supplementary parameters to assess coagulation and fibrinolysis. One further parameter, clot lysis time (CLT), can also be determined. The OHP assay measures the integrated effect of procoagulant, anticoagulant, and fibrinolytic factors.

The OHP is a technically simple but relatively labor-intensive assay. As of 2010, it had been implemented in several laboratories, but was not available commercially. The assay is novel in terms of its combined evaluation of both fibrin generation and fibrinolysis. The test is potentially useful in the evaluation of hypercoagulability, hypocoagulability, and fibrinolytic abnormalities. It is able to detect hypercoagulability associated with pregnancy and estrogen/progestogen hormone therapy. The test has also been used to study coagulation in feminizing hormone therapy in transgender women.{{cite journal | vauthors = Lim HY, Leemaqz SY, Torkamani N, Grossmann M, Zajac JD, Nandurkar H, Ho P, Cheung AS | title = Global Coagulation Assays in Transgender Women on Oral and Transdermal Estradiol Therapy | journal = J Clin Endocrinol Metab | volume = 105 | issue = 7 | pages = e2369–e2377| date = July 2020 | pmid = 32413907 | doi = 10.1210/clinem/dgaa262 | url = | doi-access = free }} However, more studies are needed to validate the test as a biomarker of thrombosis and other abnormalities of coagulation.