Oxford Nanopore Technologies#Products

The company was founded in 2005 as a spin-out from the University of Oxford by Hagan Bayley,{{Who's Who | title=BAYLEY, Prof. (John) Hagan (Pryce) | id = U44745 | volume = 2015 | edition = online edition via Oxford University Press}} Gordon Sanghera, and Spike Willcocks, with seed funding from the IP Group.{{cite news |date=2008-10-16 |title=DNA sequencing: The hole story |url=http://www.economist.com/node/12415210 |newspaper=The Economist |location=London |access-date=2014-10-19}} The company made an initial public offering on the London Stock Exchange on 30 September 2021, under the ticker ONT. {{cite web |url= https://www.londonstockexchange.com/discover/news-and-insights/london-stock-exchange-welcomes-oxford-nanopore-technologies-plc-main-market |title= London Stock Exchange welcomes Oxford Nanopore Technologies plc to the Main Market |date=2021-10-11}}

In March 2016 the company announced a chemistry upgrade to its nanopore sequencing product 'R9', using a protein nanopore in collaboration with the laboratory of Han Remaut (VIB/Vrije Universiteit Brussel).{{cite web |url=http://www.vib.be/en/news/Pages/VIB-announces-collaboration-with-Oxford-Nanopore-Technologies-on-new-DNA-sequencing-nanopore.aspx |title=VIB announces collaboration with Oxford Nanopore Technologies on new DNA sequencing nanopore |access-date=2016-05-09 }} The company stated in a webcast that R9 is designed to improve error rates and yield.{{cite web |title=No thanks, I've already got one |website = YouTube| date=8 March 2016 |url=https://www.youtube.com/watch?v=nizGyutn6v4 |access-date=2016-05-09 }}

File:First-ever sequencing of DNA in space, performed by Kate Rubins on the ISS. 128f0462 sequencer 1.jpg with a MinION sequencer on the ISS in August 2016.]]

In July 2016, a MinION nanopore sequencer was included on the ninth NASA/SpaceX commercial cargo resupply services mission to the International Space Station.{{Cite web|url=http://www.nasa.gov/press-release/next-spacex-commercial-cargo-launch-now-no-earlier-than-july-18-us-media-accreditation|title=Next SpaceX Commercial Cargo Launch Now No Earlier Than July 18|last=Ramsey|first=Sarah|date=2016-06-21|access-date=2016-07-25}} The aim of the mission was to provide proof of concept for the MinION's functionality in a microgravity environment.{{Cite web|url=http://spaceref.com/nasa-hack-space/sequencing-dna-in-space.html|title=Sequencing DNA in Space - SpaceRef|website=spaceref.com|access-date=2016-07-25}} During the mission, ISS crew members successfully sequenced DNA from bacteria, bacteriophage and rodents from samples prepared on Earth.{{Cite news|url=http://www.nasa.gov/mission_pages/station/research/news/dna_sequencing/|title=First DNA Sequencing in Space a Game Changer|last=Rainey|first=Kristine|date=2016-08-29|newspaper=NASA|access-date=2016-10-17}} Maintaining the MinION device as a research facility on the space station holds the potential to support a number of additional science investigations, any of which could have Earth based applications.{{cite bioRxiv|last1=McIntyre|first1=Alexa B. R.|last2=Rizzardi|first2=Lindsay|last3=Yu|first3=Angela M.|last4=Rosen|first4=Gail L.|last5=Alexander|first5=Noah|last6=Botkin|first6=Douglas J.|last7=John|first7=Kristen K.|last8=Castro-Wallace|first8=Sarah L.|last9=Burton|first9=Aaron S.|date=2015-12-10|title=Nanopore Sequencing in Microgravity|biorxiv=10.1101/032342}}

File:Oxford Nanopore MinION top cropped.jpg

The main products of Oxford Nanopore are:

• MinION:{{Cite journal

| pmid = 25187008

| year = 2014

| last1 = Mikheyev

| first1 = A. S.

| title = A first look at the Oxford Nanopore MinION sequencer

| journal = Molecular Ecology Resources

| volume = 14

| issue = 6

| pages = 1097–102

| last2 = Tin

| first2 = M. M. Y.

| doi = 10.1111/1755-0998.12324

| bibcode = 2014MolER..14.1097M

| s2cid = 3674911

}}{{Cite journal | doi = 10.1038/nature.2014.14724| title = Data from pocket-sized genome sequencer unveiled| journal = Nature| year = 2014| last1 = Check Hayden | first1 = E. | doi-access = free}}{{Cite journal | doi = 10.1038/521015a| title = Pint-sized DNA sequencer impresses first users| journal = Nature| volume = 521| issue = 7550| pages = 15–6| year = 2015| last1 = Check Hayden | first1 = E.| pmid=25951262| bibcode = 2015Natur.521...15C| doi-access = free}} this harmonica-sized portable protein nanopore sequencing USB device has been commercially available since May 2015{{cite web|url=http://www.ipgroupplc.com/media-centre/ip-group-news/2015/2015-07-21.aspx |title=IP Group PLC – Portfolio company Oxford Nanopore announces £70m fundraising – IP Group PLC |access-date=November 20, 2015 |url-status=dead |archive-url=https://web.archive.org/web/20151121024012/http://www.ipgroupplc.com/media-centre/ip-group-news/2015/2015-07-21.aspx |archive-date=November 21, 2015 }} after having been launched initially through an early access program, the MinION Access Program (MAP).{{cite journal|last1=Loman|first1=Nicholas J|last2=Watson|first2=Mick|title=Successful test launch for nanopore sequencing|journal=Nature Methods|volume=12|issue=4|year=2015|pages=303–304|issn=1548-7091|doi=10.1038/nmeth.3327|pmid=25825834|s2cid=5604121}}

• GridION X5: this desktop device has been commercially available since March 2017.{{Cite news|url=https://www.genomeweb.com/sequencing/oxford-nanopore-launches-gridion-x5-nanopore-sequencer-details-product-improvements|title=Oxford Nanopore Launches GridIon X5 Nanopore Sequencer, Details Product Improvements|work=GenomeWeb|access-date=2017-07-06|language=en}} The device processes up to five MinION Flow Cells and enables generation of up to 100 Gb of data per run.{{Cite web|url=https://nanoporetech.com/products/gridion|title=GridION X5|website=nanoporetech.com|language=en|access-date=2017-07-06}}
• PromethION: this desktop, high throughput device will be available through an access program{{cite web|url=https://nanoporetech.com/community/promethion-access-programme|title=Community - Oxford Nanopore Technologies|access-date=2015-06-17|archive-url=https://web.archive.org/web/20150627171625/https://nanoporetech.com/community/promethion-access-programme|archive-date=2015-06-27|url-status=dead}} that opened for registration in July 2015. The device contains channels for 144,000 nanopores (in comparison to MinION’s 512).{{cite web|url=https://nanoporetech.com/community/specifications|title=Specifications - Community - Oxford Nanopore Technologies|access-date=2015-11-20|archive-url=https://web.archive.org/web/20160601141421/https://www.nanoporetech.com/community/specifications|archive-date=2016-06-01|url-status=dead}}
• VolTRAX: this device is designed for automated sample preparation so that users do not need a laboratory or lab skills to run the device.{{cite web|url=http://nextgenseek.com/2015/05/oxford-nanopore-cto-clive-browns-talk-at-london-calling-minion-asic-voltrax-promethion/|title=Oxford Nanopore CTO Clive Brown's Talk at London Calling: MinION ASIC, volTRAX, promethION|work=Next Gen Seek|date=14 May 2015}} Registration for the early access program was opened in October 2016.{{Cite web|url=https://nanoporetech.com/products/voltrax|title=VolTRAX|website=nanoporetech.com|access-date=2016-10-17}}
• Metrichor: this spinout company from Oxford Nanopore was set up to provide end to end solutions for biological analyses, using nanopore sensing technologies.{{cite magazine|url=https://www.wired.co.uk/news/archive/2015-04/24/clive-brown-oxford-nanopore-technologies-wired-health-2015|title=Oxford Nanopore: we want to create the internet of living things|magazine=Wired UK}}{{Cite web|url=https://metrichor.com/about.shtml|title=Metrichor|website=metrichor.com|access-date=2016-08-17}}
• SmidgION: a mobile phone sequencer announced in May 2016, currently in development.{{Cite web|url=https://www2.nanoporetech.com/products-services/smidgion|title=SmidgION - Products & services - Oxford Nanopore Technologies|website=www2.nanoporetech.com|access-date=2016-08-17|archive-url=https://web.archive.org/web/20160823022022/https://www2.nanoporetech.com/products-services/smidgion|archive-date=2016-08-23|url-status=dead}}

These products are intended to be used for the analysis of DNA, RNA, proteins and small molecules with a range of applications in personalized medicine, crop science, and scientific research.{{cite journal|last1=Check Hayden|first1=Erika|title=Nanopore genome sequencer makes its debut|journal=Nature|year=2012|issn=1744-7933|doi=10.1038/nature.2012.10051|doi-access=free}}

{{reflist|35em}}

• [https://nanoporetech.com/ Oxford Nanopore Technologies Website]

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Category:British companies established in 2005

Category:Companies based in Oxford

Category:Genomics companies

Category:Technology companies established in 2005

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