Oxycodone/paracetamol
{{Short description|Pain medication}}
{{Redirect2|Percocet|Percs|the band|Percocettes|the supercomputer technology|PERCS|the cleaning chemical PERC|tetrachloroethylene|}}
{{Use dmy dates|date=October 2022}}
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{{Drugbox
| Verifiedfields = changed
| Watchedfields = changed
| verifiedrevid = 455187452
| type = combo
| image =
| alt =
| caption =
| component1 = Oxycodone
| class1 = Opioid analgesic
| component2 = Acetaminophen
| class2 = Anilide analgesic
| tradename = Percocet, others
| Drugs.com = {{ubl
| {{drugs.com|parent|acetaminophen-and-oxycodone}}
| {{drugs.com|ppa|oxycodone-and-acetaminophen}}
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| MedlinePlus =
| DailyMedID = Oxycodone hydrochloride and acetaminophen
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| routes_of_administration = By mouth
| ATC_prefix = N02
| ATC_suffix = AJ17
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| legal_US = Schedule II
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| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 330988-72-2
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| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 4881971
| KEGG = D02153
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Oxycodone/paracetamol, sold under the brand name Percocet among others,{{cite web | title=Oxycodone / Acetaminophen: Uses, Dosage & More | website=Drugs.com | date=5 March 2023 | url=https://www.drugs.com/acetaminophen-and-oxycodone.html | access-date=7 February 2025}} is a fixed-dose combination of the opioid oxycodone with paracetamol (acetaminophen), used to treat moderate to severe pain.
In 2022, it was the 98th most commonly prescribed medication in the United States, with more than 6{{nbsp}}million prescriptions.{{cite web | title=The Top 300 of 2022 | url=https://clincalc.com/DrugStats/Top300Drugs.aspx | website=ClinCalc | access-date=30 August 2024 | archive-date=30 August 2024 | archive-url=https://web.archive.org/web/20240830202410/https://clincalc.com/DrugStats/Top300Drugs.aspx | url-status=live }}{{cite web | title = Acetaminophen; Oxycodone Drug Usage Statistics, United States, 2013 - 2022 | website = ClinCalc | url = https://clincalc.com/DrugStats/Drugs/AcetaminophenOxycodone | access-date = 30 August 2024 }}
History
The United States Food and Drug Administration (FDA) first approved oxycodone/paracetamol in 1976, under application ANDA 085106.{{cite web | title=Percocet: FDA-Approved Drugs | website=U.S. Food and Drug Administration (FDA) | url=https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=085106 | access-date=17 October 2021}}
Society and culture
= Implicated in deaths =
In June 2009, an FDA advisory panel recommended that Percocet, Vicodin, and every other combination of acetaminophen with narcotic analgesics{{cite web|url=http://www.webmd.com/pain-management/news/20090701/fda-may-restrict-acetaminophen|title=FDA May Restrict Acetaminophen|work=WebMD}} be limited in their sales because of their contributions to an alleged 400 acetaminophen-related deaths in the U.S. each year, that were attributed to acetaminophen overdose and associated liver damage.{{cite news| url=https://www.nytimes.com/2009/07/01/health/01fda.html | work=The New York Times | title=Ban Is Advised on 2 Top Pills for Pain Relief | first=Gardiner | last=Harris | date=30 June 2009 | access-date=22 May 2010}}
In December 2009, a study found a fivefold increase in oxycodone-related deaths in Ontario, Canada (mostly accidental) between 1991 and 2007 that led to a doubling of all opioid-related deaths in Ontario over the same period.{{cite journal | vauthors = Dhalla IA, Mamdani MM, Sivilotti ML, Kopp A, Qureshi O, Juurlink DN | title = Prescribing of opioid analgesics and related mortality before and after the introduction of long-acting oxycodone | journal = CMAJ | volume = 181 | issue = 12 | pages = 891–6 | date = December 2009 | pmid = 19969578 | pmc = 2789126 | doi = 10.1503/cmaj.090784 }}{{cite journal | vauthors = Fischer B, Rehm J | title = Deaths related to the use of prescription opioids | journal = CMAJ | volume = 181 | issue = 12 | pages = 881–2 | date = December 2009 | pmid = 19969577 | pmc = 2789122 | doi = 10.1503/cmaj.091791 }}{{cite journal|journal=Canadian Medical Association Journal |date=7 December 2009 |title=Deaths from opioid use have doubled; five-fold increase in oxycodone deaths |access-date=31 May 2012 |url=https://www.sciencedaily.com/releases/2009/12/091207123105.htm}}
References
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{{Analgesics}}
{{Anti-inflammatory products}}
{{Opioidergics}}
{{Drug use}}
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{{DEFAULTSORT:Oxycodone Paracetamol}}