P/D1 cell

P/D1 cells are cells lining the fundus of the human stomach that produce ghrelin. Removal of these cells in gastric bypass surgery has a profound impact on later appetite regulation.{{cite journal |vauthors=Inui A, Asakawa A, Bowers CY, etal |title=Ghrelin, appetite, and gastric motility: the emerging role of the stomach as an endocrine organ |journal=FASEB J. |volume=18 |issue=3 |pages=439–56 |year=2004 |pmid=15003990 |doi=10.1096/fj.03-0641rev |doi-access=free |s2cid=15642270 |url=http://www.fasebj.org/cgi/content/full/18/3/439|url-access=subscription }} These cells have also been shown to produce ghrelin's antagonistic hormone leptin.{{cite journal | vauthors = Bado A, Levasseur S, Attoub S, Kermorgant S, Laigneau JP, Bortoluzzi MN, Moizo L, Lehy T, Guerre-Millo M, Le Marchand-Brustel Y, Lewin MJ | year = 1998 | title = The stomach is a source of leptin | journal = Nature | volume = 394 | issue = 6695| pages = 790–793 | doi = 10.1038/29547 | pmid = 9723619 | bibcode = 1998Natur.394..790B | s2cid = 4367948 }} PD/1 cells are equivalent to A-like cells in rats and X-type cells in dogs. These endocrine cells can be microscopically distinguished from other gastric endocrine cells through their round, compact, electron-dense secretory granules.{{cite journal |last1=Sakata |first1=Ichiro |last2=Sakai |first2=Takafumi |title=Ghrelin Cells in the Gastrointestinal Tract |journal=International Journal of Peptides |date=14 March 2010 |volume=2010 |pages=1–7 |doi=10.1155/2010/945056 |pmid=20798855 |pmc=2925405 |doi-access=free }}