P22

P22 may refer to:

P22 (type foundry), a digital type foundry, Rochester, New York, United States
{{LÉ|Aoife|P22}}, a patrol vessel of the Irish Naval Service
Curtiss XP-22 Hawk, an experimental biplane fighter
{{Ship|Maltese patrol boat|P22}}, of the Armed Forces of Malta
Mwera language
Papyrus 22, a biblical manuscript
Salmonella virus P22, a bacteriophage
Walther P22, a pistol
Norfolk Southern train P22, involved in the 2005 Graniteville train crash, South Carolina, United States
P22, a state regional road in Latvia
P-22, a mountain lion that resided in Griffith Park, Los Angeles, California, United States