P2RY1

The product of this gene, P2Y₁ belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor functions as a receptor for extracellular ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation.{{cite web | title = Entrez Gene: P2RY1 purinergic receptor P2Y, G-protein coupled, 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5028}}

• P2Y receptor

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• {{cite journal | vauthors = Janssens R, Communi D, Pirotton S, Samson M, Parmentier M, Boeynaems JM | title = Cloning and tissue distribution of the human P2Y1 receptor | journal = Biochemical and Biophysical Research Communications | volume = 221 | issue = 3 | pages = 588–93 | date = April 1996 | pmid = 8630005 | doi = 10.1006/bbrc.1996.0640 | url = https://dipot.ulb.ac.be/dspace/bitstream/2013/50234/4/d2e5b4da-6bd0-4540-86dc-20629565c59a.txt | url-access = subscription }}
• {{cite journal | vauthors = Léon C, Vial C, Cazenave JP, Gachet C | title = Cloning and sequencing of a human cDNA encoding endothelial P2Y1 purinoceptor | journal = Gene | volume = 171 | issue = 2 | pages = 295–7 | date = June 1996 | pmid = 8666290 | doi = 10.1016/0378-1119(96)00027-3 }}
• {{cite journal | vauthors = Léon C, Hechler B, Vial C, Leray C, Cazenave JP, Gachet C | title = The P2Y1 receptor is an ADP receptor antagonized by ATP and expressed in platelets and megakaryoblastic cells | journal = FEBS Letters | volume = 403 | issue = 1 | pages = 26–30 | date = February 1997 | pmid = 9038354 | doi = 10.1016/S0014-5793(97)00022-7 | s2cid = 10518131 | doi-access = }}
• {{cite journal | vauthors = Ayyanathan K, Naylor SL, Kunapuli SP | title = Structural characterization and fine chromosomal mapping of the human P2Y1 purinergic receptor gene (P2RY1) | journal = Somatic Cell and Molecular Genetics | volume = 22 | issue = 5 | pages = 419–24 | date = September 1996 | pmid = 9039850 | doi = 10.1007/BF02369897 | s2cid = 28971344 }}
• {{cite journal | vauthors = Maier R, Glatz A, Mosbacher J, Bilbe G | title = Cloning of P2Y6 cDNAs and identification of a pseudogene: comparison of P2Y receptor subtype expression in bone and brain tissues | journal = Biochemical and Biophysical Research Communications | volume = 237 | issue = 2 | pages = 297–302 | date = August 1997 | pmid = 9268704 | doi = 10.1006/bbrc.1997.7135 }}
• {{cite journal | vauthors = Jin J, Daniel JL, Kunapuli SP | title = Molecular basis for ADP-induced platelet activation. II. The P2Y1 receptor mediates ADP-induced intracellular calcium mobilization and shape change in platelets | journal = The Journal of Biological Chemistry | volume = 273 | issue = 4 | pages = 2030–4 | date = January 1998 | pmid = 9442040 | doi = 10.1074/jbc.273.4.2030 | doi-access = free }}
• {{cite journal | vauthors = Hall RA, Ostedgaard LS, Premont RT, Blitzer JT, Rahman N, Welsh MJ, Lefkowitz RJ | title = A C-terminal motif found in the beta2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na+/H+ exchanger regulatory factor family of PDZ proteins | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 15 | pages = 8496–501 | date = July 1998 | pmid = 9671706 | pmc = 21104 | doi = 10.1073/pnas.95.15.8496 | bibcode = 1998PNAS...95.8496H | doi-access = free }}
• {{cite journal | vauthors = Sabala P, Czajkowski R, Przybyłek K, Kalita K, Kaczmarek L, Barańska J | title = Two subtypes of G protein-coupled nucleotide receptors, P2Y(1) and P2Y(2) are involved in calcium signalling in glioma C6 cells | journal = British Journal of Pharmacology | volume = 132 | issue = 2 | pages = 393–402 | date = January 2001 | pmid = 11159687 | pmc = 1572584 | doi = 10.1038/sj.bjp.0703843 }}
• {{cite journal | vauthors = Yoshioka K, Saitoh O, Nakata H | title = Heteromeric association creates a P2Y-like adenosine receptor | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 98 | issue = 13 | pages = 7617–22 | date = June 2001 | pmid = 11390975 | pmc = 34717 | doi = 10.1073/pnas.121587098 | doi-access = free | bibcode = 2001PNAS...98.7617Y }}
• {{cite journal | vauthors = James G, Butt AM | title = Changes in P2Y and P2X purinoceptors in reactive glia following axonal degeneration in the rat optic nerve | journal = Neuroscience Letters | volume = 312 | issue = 1 | pages = 33–6 | date = October 2001 | pmid = 11578839 | doi = 10.1016/S0304-3940(01)02189-9 | s2cid = 30936205 }}
• {{cite journal | vauthors = Moore DJ, Chambers JK, Wahlin JP, Tan KB, Moore GB, Jenkins O, Emson PC, Murdock PR | title = Expression pattern of human P2Y receptor subtypes: a quantitative reverse transcription-polymerase chain reaction study | journal = Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression | volume = 1521 | issue = 1–3 | pages = 107–19 | date = October 2001 | pmid = 11690642 | doi = 10.1016/S0167-4781(01)00291-3 }}
• {{cite journal | vauthors = Czajkowski R, Lei L, Sabała P, Barańska J | title = ADP-evoked phospholipase C stimulation and adenylyl cyclase inhibition in glioma C6 cells occur through two distinct nucleotide receptors, P2Y(1) and P2Y(12) | journal = FEBS Letters | volume = 513 | issue = 2–3 | pages = 179–83 | date = February 2002 | pmid = 11904146 | doi = 10.1016/S0014-5793(02)02255-X | s2cid = 43212335 | doi-access = }}
• {{cite journal | vauthors = Aktas B, Hönig-Liedl P, Walter U, Geiger J | title = Inhibition of platelet P2Y12 and alpha2A receptor signaling by cGMP-dependent protein kinase | journal = Biochemical Pharmacology | volume = 64 | issue = 3 | pages = 433–9 | date = August 2002 | pmid = 12147294 | doi = 10.1016/S0006-2952(02)01113-9 }}
• {{cite journal | vauthors = Nurden P, Poujol C, Winckler J, Combrié R, Pousseau N, Conley PB, Levy-Toledano S, Habib A, Nurden AT | title = Immunolocalization of P2Y1 and TPalpha receptors in platelets showed a major pool associated with the membranes of alpha -granules and the open canalicular system | journal = Blood | volume = 101 | issue = 4 | pages = 1400–8 | date = February 2003 | pmid = 12393588 | doi = 10.1182/blood-2002-02-0642 | s2cid = 30407515 | doi-access = free }}
• {{cite journal | vauthors = Burrell HE, Bowler WB, Gallagher JA, Sharpe GR | title = Human keratinocytes express multiple P2Y-receptors: evidence for functional P2Y1, P2Y2, and P2Y4 receptors | journal = The Journal of Investigative Dermatology | volume = 120 | issue = 3 | pages = 440–7 | date = March 2003 | pmid = 12603858 | doi = 10.1046/j.1523-1747.2003.12050.x | doi-access = free }}
• {{cite journal | vauthors = Jagroop IA, Burnstock G, Mikhailidis DP | title = Both the ADP receptors P2Y1 and P2Y12, play a role in controlling shape change in human platelets | journal = Platelets | volume = 14 | issue = 1 | pages = 15–20 | date = February 2003 | pmid = 12623443 | doi = 10.1080/0953710021000062914 | s2cid = 13637415 }}
• {{cite journal | vauthors = Greig AV, Linge C, Terenghi G, McGrouther DA, Burnstock G | title = Purinergic receptors are part of a functional signaling system for proliferation and differentiation of human epidermal keratinocytes | journal = The Journal of Investigative Dermatology | volume = 120 | issue = 6 | pages = 1007–15 | date = June 2003 | pmid = 12787128 | doi = 10.1046/j.1523-1747.2003.12261.x }}
• {{cite journal | vauthors = Wang L, Ostberg O, Wihlborg AK, Brogren H, Jern S, Erlinge D | title = Quantification of ADP and ATP receptor expression in human platelets | journal = Journal of Thrombosis and Haemostasis | volume = 1 | issue = 2 | pages = 330–6 | date = February 2003 | pmid = 12871508 | doi = 10.1046/j.1538-7836.2003.00070.x | s2cid = 19101147 | doi-access =free }}

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• {{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2392 | title = P2Y Receptors: P2Y₁ | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | access-date = 2008-12-09 | archive-date = 2016-03-03 | archive-url = https://web.archive.org/web/20160303174316/http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2392 | url-status = dead }}

{{NLM content}}

{{G protein-coupled receptors}}

{{Purinergics}}

Category:G protein-coupled receptors

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