P2RY11
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
P2Y purinoceptor 11 is a protein that in humans is encoded by the P2RY11 gene.{{cite journal |vauthors=Communi D, Govaerts C, Parmentier M, Boeynaems JM | title = Cloning of a human purinergic P2Y receptor coupled to phospholipase C and adenylyl cyclase | journal = J Biol Chem | volume = 272 | issue = 51 | pages = 31969–73 |date=Jan 1998 | pmid = 9405388 | doi =10.1074/jbc.272.51.31969 | doi-access = free }}{{cite web | title = Entrez Gene: P2RY11 purinergic receptor P2Y, G-protein coupled, 11| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5032}}
The product of this gene, P2Y11, belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is coupled to the stimulation of the phosphoinositide and adenylyl cyclase pathways and behaves as a selective purinoceptor. Naturally occurring read-through transcripts, resulting from intergenic splicing between this gene and an immediately upstream gene (PPAN, encoding peter pan homolog), have been found. The PPAN-P2RY11 read-through mRNA is ubiquitously expressed and encodes a fusion protein that shares identity with each individual gene product.
See also
References
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Further reading
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- {{cite journal |vauthors=van der Weyden L, Conigrave AD, Morris MB |title=Signal transduction and white cell maturation via extracellular ATP and the P2Y11 receptor |journal=Immunol. Cell Biol. |volume=78 |issue= 4 |pages= 369–74 |year= 2000 |pmid= 10947861 |doi=10.1046/j.1440-1711.2000.00918.x |s2cid=25036526 }}
- {{cite journal | author=Adams MD |title=Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence |journal=Nature |volume=377 |issue= 6547 Suppl |pages= 3–174 |year= 1995 |pmid= 7566098 |url=http://www.columbia.edu/itc/biology/pollack/w4065/client_edit/readings/nature377_3.pdf |name-list-style=vanc| author2=Kerlavage AR | author3=Fleischmann RD | display-authors=3 | last4=Fuldner | first4=RA | last5=Bult | first5=CJ | last6=Lee | first6=NH | last7=Kirkness | first7=EF | last8=Weinstock | first8=KG | last9=Gocayne | first9=JD }}
- {{cite journal | author=Communi D |title=Cotranscription and intergenic splicing of human P2Y11 and SSF1 genes |journal=J. Biol. Chem. |volume=276 |issue= 19 |pages= 16561–6 |year= 2001 |pmid= 11278528 |doi= 10.1074/jbc.M009609200 |name-list-style=vanc| author2=Suarez-Huerta N | author3=Dussossoy D | display-authors=3 | last4=Savi | first4=P | last5=Boeynaems | first5=JM |doi-access=free }}
- {{cite journal | author=Moore DJ |title=Expression pattern of human P2Y receptor subtypes: a quantitative reverse transcription-polymerase chain reaction study |journal=Biochim. Biophys. Acta |volume=1521 |issue= 1–3 |pages= 107–19 |year= 2001 |pmid= 11690642 |doi= 10.1016/S0167-4781(01)00291-3|name-list-style=vanc| author2=Chambers JK | author3=Wahlin JP | display-authors=3 | last4=Tan | first4=KB | last5=Moore | first5=GB | last6=Jenkins | first6=O | last7=Emson | first7=PC | last8=Murdock | first8=PR }}
- {{cite journal | author=Duhant X |title=Extracellular adenine nucleotides inhibit the activation of human CD4+ T lymphocytes |journal=J. Immunol. |volume=169 |issue= 1 |pages= 15–21 |year= 2002 |pmid= 12077223 |doi= 10.4049/jimmunol.169.1.15|name-list-style=vanc| author2=Schandené L | author3=Bruyns C | display-authors=3 | last4=Gonzalez | first4=NS | last5=Goldman | first5=M | last6=Boeynaems | first6=JM | last7=Communi | first7=D | doi-access=free }}
- {{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-style=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-style=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}
- {{cite journal | author=Moreschi I |title=Extracellular NAD+ is an agonist of the human P2Y11 purinergic receptor in human granulocytes |journal=J. Biol. Chem. |volume=281 |issue= 42 |pages= 31419–29 |year= 2006 |pmid= 16926152 |doi= 10.1074/jbc.M606625200 |name-list-style=vanc| author2=Bruzzone S | author3=Nicholas RA | display-authors=3 | last4=Fruscione | first4=F. | last5=Sturla | first5=L. | last6=Benvenuto | first6=F. | last7=Usai | first7=C. | last8=Meis | first8=S. | last9=Kassack | first9=M. U. | doi-access=free }}
- {{cite journal |vauthors=Zylberg J, Ecke D, Fischer B, Reiser G |title=Structure and ligand-binding site characteristics of the human P2Y11 nucleotide receptor deduced from computational modelling and mutational analysis |journal=Biochem. J. |volume=405 |issue= 2 |pages= 277–86 |year= 2007 |pmid= 17338680 |doi= 10.1042/BJ20061728 | pmc=1904521 }}
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External links
- {{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2400 | title = P2Y Receptors: P2Y11 | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | access-date = 2008-12-09 | archive-date = 2016-03-03 | archive-url = https://web.archive.org/web/20160303203523/http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2400 | url-status = dead }}
{{NLM content}}
{{G protein-coupled receptors}}
{{Purinergics}}
Category:G protein-coupled receptors
{{transmembranereceptor-stub}}