P2RY13
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
P2Y purinoceptor 13 is a protein that in humans is encoded by the P2RY13 gene.{{cite journal | vauthors = Wittenberger T, Schaller HC, Hellebrand S | title = An expressed sequence tag (EST) data mining strategy succeeding in the discovery of new G-protein coupled receptors | journal = J Mol Biol | volume = 307 | issue = 3 | pages = 799–813 |date=Mar 2001 | pmid = 11273702 | doi = 10.1006/jmbi.2001.4520 }}{{cite journal | vauthors = Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O, Lewis T, Evans JF, George SR, O'Dowd BF | title = Discovery and mapping of ten novel G protein-coupled receptor genes | journal = Gene | volume = 275 | issue = 1 | pages = 83–91 |date=Sep 2001 | pmid = 11574155 | doi =10.1016/S0378-1119(01)00651-5 }}{{cite web | title = Entrez Gene: P2RY13 purinergic receptor P2Y, G-protein coupled, 13| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=53829}}
The product of this gene, P2Y13, belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is activated by ADP. Two transcript variants encoding the same protein have been identified for this gene.
See also
References
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Further reading
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- {{cite journal |vauthors=Communi D, Gonzalez NS, Detheux M, etal |title=Identification of a novel human ADP receptor coupled to G(i). |journal=J. Biol. Chem. |volume=276 |issue= 44 |pages= 41479–85 |year= 2001 |pmid= 11546776 |doi= 10.1074/jbc.M105912200 |doi-access= free }}
- {{cite journal |vauthors=Zhang FL, Luo L, Gustafson E, etal |title=P2Y(13): identification and characterization of a novel Galphai-coupled ADP receptor from human and mouse. |journal=J. Pharmacol. Exp. Ther. |volume=301 |issue= 2 |pages= 705–13 |year= 2002 |pmid= 11961076 |doi=10.1124/jpet.301.2.705 }}
- {{cite journal |vauthors=Takeda S, Kadowaki S, Haga T, etal |title=Identification of G protein-coupled receptor genes from the human genome sequence. |journal=FEBS Lett. |volume=520 |issue= 1–3 |pages= 97–101 |year= 2002 |pmid= 12044878 |doi=10.1016/S0014-5793(02)02775-8 |s2cid=7116392 |doi-access=free }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal |vauthors=Fabre AC, Malaval C, Ben Addi A, etal |title=P2Y13 receptor is critical for reverse cholesterol transport |journal=Hepatology |volume=52 |issue= 4 |pages= 1477–83 |year= 2010 |pmid= 20830789 |doi= 10.1002/hep.23897 |s2cid=5833128 |doi-access=free }}
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External links
- {{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3034 | title = P2Y Receptors: P2Y13 | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | access-date = 2008-12-09 | archive-date = 2016-03-03 | archive-url = https://web.archive.org/web/20160303201018/http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3034 | url-status = dead }}
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{{G protein-coupled receptors}}
{{Purinergics}}
Category:G protein-coupled receptors
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