P2RY14

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

P2Y purinoceptor 14 is a protein that in humans is encoded by the P2RY14 gene.{{cite web | title = Entrez Gene: P2RY14 purinergic receptor P2Y, G-protein coupled, 14| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9934}}

The product of this gene, P2Y14 belongs to the family of G-protein coupled receptors, which contains several receptor subtypes with different pharmacological selectivity for various adenosine and uridine nucleotides. This receptor is a P2Y purinergic receptor for UDP-glucose and other UDP-sugars coupled to G-proteins. It has been implicated in extending the known immune system functions of P2Y receptors by participating in the regulation of the stem cell compartment, and it may also play a role in neuroimmune function. Two transcript variants encoding the same protein have been identified for this gene.

See also

References

{{reflist}}

Further reading

{{refbegin | 2}}

  • {{cite journal | vauthors=Gerard C, Gerard NP |title=C5A anaphylatoxin and its seven transmembrane-segment receptor |journal=Annu. Rev. Immunol. |volume=12 |pages= 775–808 |year= 1994 |pmid= 8011297 |doi= 10.1146/annurev.iy.12.040194.004015 }}
  • {{cite journal | author=Müller CE |title=P2-pyrimidinergic receptors and their ligands |journal=Curr. Pharm. Des. |volume=8 |issue= 26 |pages= 2353–2369 |year= 2003 |pmid= 12369950 |doi=10.2174/1381612023392937 }}
  • {{cite journal |vauthors=Abbracchio MP, Boeynaems JM, Barnard EA, etal |title=Characterization of the UDP-glucose receptor (re-named here the P2Y14 receptor) adds diversity to the P2Y receptor family |journal=Trends Pharmacol. Sci. |volume=24 |issue= 2 |pages= 52–55 |year= 2003 |pmid= 12559763 |doi=10.1016/S0165-6147(02)00038-X |pmc=8653507 }}
  • {{cite journal | author=von Kügelgen I |title=Pharmacological profiles of cloned mammalian P2Y-receptor subtypes |journal=Pharmacol. Ther. |volume=110 |issue= 3 |pages= 415–432 |year= 2006 |pmid= 16257449 |doi= 10.1016/j.pharmthera.2005.08.014 }}
  • {{cite journal | vauthors=Brunschweiger A, Müller CE |title=P2 receptors activated by uracil nucleotides--an update |journal=Curr. Med. Chem. |volume=13 |issue= 3 |pages= 289–312 |year= 2006 |pmid= 16475938 |doi=10.2174/092986706775476052 }}
  • {{cite journal |vauthors=Nomura N, Miyajima N, Sazuka T, etal |title=Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 |journal=DNA Res. |volume=1 |issue= 1 |pages= 27–35 |year= 1995 |pmid= 7584026 |doi=10.1093/dnares/1.1.27 |doi-access=free }}
  • {{cite journal |vauthors=Nomura N, Miyajima N, Sazuka T, etal |title=Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement) |journal=DNA Res. |volume=1 |issue= 1 |pages= 47–56 |year= 1995 |pmid= 7584028 |doi=10.1093/dnares/1.1.47 |doi-access=free }}
  • {{cite journal |vauthors=Charlton ME, Williams AS, Fogliano M, etal |title=The isolation and characterization of a novel G protein-coupled receptor regulated by immunologic challenge |journal=Brain Res. |volume=764 |issue= 1–2 |pages= 141–148 |year= 1997 |pmid= 9295203 |doi=10.1016/S0006-8993(97)00438-1 |s2cid=44648771 |doi-access=free }}
  • {{cite journal |vauthors=Joensuu T, Hämäläinen R, Lehesjoki AE, etal |title=A sequence-ready map of the Usher syndrome type III critical region on chromosome 3q |journal=Genomics |volume=63 |issue= 3 |pages= 409–416 |year= 2000 |pmid= 10704288 |doi= 10.1006/geno.1999.6096 }}
  • {{cite journal |vauthors=Chambers JK, Macdonald LE, Sarau HM, etal |title=A G protein-coupled receptor for UDP-glucose |journal=J. Biol. Chem. |volume=275 |issue= 15 |pages= 10767–10771 |year= 2000 |pmid= 10753868 |doi=10.1074/jbc.275.15.10767 |doi-access=free }}
  • {{cite journal | vauthors=Wittenberger T, Schaller HC, Hellebrand S |title=An expressed sequence tag (EST) data mining strategy succeeding in the discovery of new G-protein coupled receptors |journal=J. Mol. Biol. |volume=307 |issue= 3 |pages= 799–813 |year= 2001 |pmid= 11273702 |doi= 10.1006/jmbi.2001.4520 }}
  • {{cite journal |vauthors=Joensuu T, Hämäläinen R, Yuan B, etal |title=Mutations in a Novel Gene with Transmembrane Domains Underlie Usher Syndrome Type 3 |journal=Am. J. Hum. Genet. |volume=69 |issue= 4 |pages= 673–684 |year= 2001 |pmid= 11524702 |doi=10.1086/323610 | pmc=1226054 }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–16903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal | vauthors=Lazarowski ER, Shea DA, Boucher RC, Harden TK |title=Release of cellular UDP-glucose as a potential extracellular signaling molecule |journal=Mol. Pharmacol. |volume=63 |issue= 5 |pages= 1190–1197 |year= 2003 |pmid= 12695547 |doi=10.1124/mol.63.5.1190 }}
  • {{cite journal |vauthors=Lee BC, Cheng T, Adams GB, etal |title=P2Y-like receptor, GPR105 (P2Y14), identifies and mediates chemotaxis of bone-marrowhematopoietic stem cells |journal=Genes Dev. |volume=17 |issue= 13 |pages= 1592–1604 |year= 2003 |pmid= 12842911 |doi= 10.1101/gad.1071503 | pmc=196132 }}
  • {{cite journal | vauthors=Skelton L, Cooper M, Murphy M, Platt A |title=Human immature monocyte-derived dendritic cells express the G protein-coupled receptor GPR105 (KIAA0001, P2Y14) and increase intracellular calcium in response to its agonist, uridine diphosphoglucose |journal=J. Immunol. |volume=171 |issue= 4 |pages= 1941–1949 |year= 2003 |pmid= 12902497 |doi= 10.4049/jimmunol.171.4.1941|doi-access=free }}
  • {{cite journal |vauthors=Moore DJ, Murdock PR, Watson JM, etal |title=GPR105, a novel Gi/o-coupled UDP-glucose receptor expressed on brain glia and peripheral immune cells, is regulated by immunologic challenge: possible role in neuroimmune function |journal=Brain Res. Mol. Brain Res. |volume=118 |issue= 1–2 |pages= 10–23 |year= 2004 |pmid= 14559350 |doi=10.1016/S0169-328X(03)00330-9 }}

{{refend}}