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P2RY8

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

P2Y purinoceptor 8 is a protein that in humans is encoded by the P2RY8 gene.{{cite journal | vauthors = Adrian K, Bernhard MK, Breitinger HG, Ogilvie A | title = Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells | journal = Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression | volume = 1492 | issue = 1 | pages = 127–38 | date = Jun 2000 | pmid = 11004484 | doi = 10.1016/S0167-4781(00)00094-4 }}{{cite web | title = Entrez Gene: P2RY8 purinergic receptor P2Y, G-protein coupled, 8| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=286530}}

Function

The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene is moderately expressed in undifferentiated HL60 cells, and is located on both chromosomes X and Y.

Clinical relevance

Recurrent mutations in this gene have been associated to cases of diffuse large B-cell lymphoma.{{cite journal | vauthors = Lohr JG, Stojanov P, Lawrence MS, Auclair D, Chapuy B, Sougnez C, Cruz-Gordillo P, Knoechel B, Asmann YW, Slager SL, Novak AJ, Dogan A, Ansell SM, Link BK, Zou L, Gould J, Saksena G, Stransky N, Rangel-Escareño C, Fernandez-Lopez JC, Hidalgo-Miranda A, Melendez-Zajgla J, Hernández-Lemus E, Schwarz-Cruz y Celis A, Imaz-Rosshandler I, Ojesina AI, Jung J, Pedamallu CS, Lander ES, Habermann TM, Cerhan JR, Shipp MA, Getz G, Golub TR | title = Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 109 | issue = 10 | pages = 3879–84 | date = Mar 2012 | pmid = 22343534 | pmc = 3309757 | doi = 10.1073/pnas.1121343109 | bibcode = 2012PNAS..109.3879L | doi-access = free }}

See also

References

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Further reading

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  • {{cite journal | vauthors = Cantagrel V, Lossi AM, Boulanger S, Depetris D, Mattei MG, Gecz J, Schwartz CE, Van Maldergem L, Villard L | title = Disruption of a new X linked gene highly expressed in brain in a family with two mentally retarded males | journal = Journal of Medical Genetics | volume = 41 | issue = 10 | pages = 736–42 | date = Oct 2004 | pmid = 15466006 | pmc = 1735597 | doi = 10.1136/jmg.2004.021626 }}
  • {{cite journal | vauthors = Fujiwara S, Yamashita Y, Choi YL, Watanabe H, Kurashina K, Soda M, Enomoto M, Hatanaka H, Takada S, Ozawa K, Mano H | title = Transforming activity of purinergic receptor P2Y, G protein coupled, 8 revealed by retroviral expression screening | journal = Leukemia & Lymphoma | volume = 48 | issue = 5 | pages = 978–86 | date = May 2007 | pmid = 17487742 | doi = 10.1080/10428190701225882 | s2cid = 678068 }}
  • {{cite journal | vauthors = Storlazzi CT, Albano F, Lo Cunsolo C, Doglioni C, Guastadisegni MC, Impera L, Lonoce A, Funes S, Macrì E, Iuzzolino P, Panagopoulos I, Specchia G, Rocchi M | title = Upregulation of the SOX5 by promoter swapping with the P2RY8 gene in primary splenic follicular lymphoma | journal = Leukemia | volume = 21 | issue = 10 | pages = 2221–5 | date = Oct 2007 | pmid = 17554380 | doi = 10.1038/sj.leu.2404784 | doi-access = free }}

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{{NLM content}}

{{G protein-coupled receptors}}

{{Purinergics}}

Category:G protein-coupled receptors

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