P4HTM
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Prolyl 4-hydroxylase, transmembrane is a protein that in humans is encoded by the P4HTM gene.
{{cite web
| title = Entrez Gene: Prolyl 4-hydroxylase, transmembrane
| url = https://www.ncbi.nlm.nih.gov/gene/54681
| access-date = 2017-10-03
}}
Function
The product of this gene belongs to the family of prolyl 4-hydroxylases. This protein is a prolyl hydroxylase that may be involved in the degradation of hypoxia-inducible transcription factors under normoxia. It plays a role in adaptation to hypoxia and may be related to cellular oxygen sensing. Alternatively spliced variants encoding different isoforms have been identified.
References
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Further reading
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- {{cite journal |vauthors=Oehme F, Ellinghaus P, Kolkhof P, Smith TJ, Ramakrishnan S, Hütter J, Schramm M, Flamme I |title=Overexpression of PH-4, a novel putative proline 4-hydroxylase, modulates activity of hypoxia-inducible transcription factors |journal=Biochem. Biophys. Res. Commun. |volume=296 |issue=2 |pages=343–9 |year=2002 |pmid=12163023 |doi= 10.1016/s0006-291x(02)00862-8}}
- {{cite journal |vauthors=Hirsilä M, Koivunen P, Günzler V, Kivirikko KI, Myllyharju J |title=Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor |journal=J. Biol. Chem. |volume=278 |issue=33 |pages=30772–80 |year=2003 |pmid=12788921 |doi=10.1074/jbc.M304982200 |doi-access=free }}
- {{cite journal |vauthors=Pekkala M, Hieta R, Bergmann U, Kivirikko KI, Wierenga RK, Myllyharju J |title=The peptide-substrate-binding domain of collagen prolyl 4-hydroxylases is a tetratricopeptide repeat domain with functional aromatic residues |journal=J. Biol. Chem. |volume=279 |issue=50 |pages=52255–61 |year=2004 |pmid=15456751 |doi=10.1074/jbc.M410007200 |doi-access=free }}
- {{cite journal |vauthors=Hirota K, Semenza GL |title=Regulation of hypoxia-inducible factor 1 by prolyl and asparaginyl hydroxylases |journal=Biochem. Biophys. Res. Commun. |volume=338 |issue=1 |pages=610–6 |year=2005 |pmid=16154531 |doi=10.1016/j.bbrc.2005.08.193 |doi-access=free }}
- {{cite journal |vauthors=Iwahashi M, Muragaki Y, Ino K |title=Human prolyl hydroxylase expression in uterine leiomyoma during the menstrual cycle |journal=Reprod. Biol. Endocrinol. |volume=10 |pages=111 |year=2012 |pmid=23241241 |pmc=3566935 |doi=10.1186/1477-7827-10-111 |doi-access=free }}
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