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PAG1

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 is a protein that in humans is encoded by the PAG1 gene.{{cite journal | vauthors = Brdicka T, Pavlistová D, Leo A, Bruyns E, Korínek V, Angelisová P, Scherer J, Shevchenko A, Hilgert I, Cerný J, Drbal K, Kuramitsu Y, Kornacker B, Horejsí V, Schraven B | title = Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation | journal = The Journal of Experimental Medicine | volume = 191 | issue = 9 | pages = 1591–604 | date = May 2000 | pmid = 10790433 | pmc = 2213442 | doi = 10.1084/jem.191.9.1591 }}{{cite web | title = Entrez Gene: PAG1 phosphoprotein associated with glycosphingolipid microdomains 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55824| access-date = }}

The protein encoded by this gene is a type III transmembrane adaptor protein that binds to the tyrosine kinase csk protein. It is thought to be involved in the regulation of T cell activation.{{cite web | title = Entrez Gene: PAG1 phosphoprotein associated with glycosphingolipid microdomains 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55824| access-date = }}

Interactions

PAG1 has been shown to interact with FYN, C-src tyrosine kinase, Sodium-hydrogen antiporter 3 regulator 1{{cite journal | vauthors = Brdicková N, Brdicka T, Andera L, Spicka J, Angelisová P, Milgram SL, Horejsí V | title = Interaction between two adapter proteins, PAG and EBP50: a possible link between membrane rafts and actin cytoskeleton | journal = FEBS Letters | volume = 507 | issue = 2 | pages = 133–6 | date = October 2001 | pmid = 11684085 | doi = 10.1016/S0014-5793(01)02955-6 | s2cid = 12676563 | doi-access = free }} and Abl gene.{{cite journal | vauthors = Wen ST, Van Etten RA | title = The PAG gene product, a stress-induced protein with antioxidant properties, is an Abl SH3-binding protein and a physiological inhibitor of c-Abl tyrosine kinase activity | journal = Genes & Development | volume = 11 | issue = 19 | pages = 2456–67 | date = October 1997 | pmid = 9334312 | pmc = 316562 | doi = 10.1101/gad.11.19.2456 }}

References

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Further reading

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  • {{cite journal | vauthors = Wen ST, Van Etten RA | title = The PAG gene product, a stress-induced protein with antioxidant properties, is an Abl SH3-binding protein and a physiological inhibitor of c-Abl tyrosine kinase activity | journal = Genes & Development | volume = 11 | issue = 19 | pages = 2456–67 | date = October 1997 | pmid = 9334312 | pmc = 316562 | doi = 10.1101/gad.11.19.2456 }}
  • {{cite journal | vauthors = Brdicková N, Brdicka T, Andera L, Spicka J, Angelisová P, Milgram SL, Horejsí V | title = Interaction between two adapter proteins, PAG and EBP50: a possible link between membrane rafts and actin cytoskeleton | journal = FEBS Letters | volume = 507 | issue = 2 | pages = 133–6 | date = October 2001 | pmid = 11684085 | doi = 10.1016/S0014-5793(01)02955-6 | s2cid = 12676563 | doi-access = free }}
  • {{cite journal | vauthors = Tedoldi S, Paterson JC, Hansmann ML, Natkunam Y, Rüdiger T, Angelisova P, Du MQ, Roberton H, Roncador G, Sanchez L, Pozzobon M, Masir N, Barry R, Pileri S, Mason DY, Marafioti T, Horejsí V | title = Transmembrane adaptor molecules: a new category of lymphoid-cell markers | journal = Blood | volume = 107 | issue = 1 | pages = 213–21 | date = January 2006 | pmid = 16160011 | doi = 10.1182/blood-2005-06-2273 | s2cid = 340034 | doi-access = free }}
  • {{cite journal | vauthors = Jiang LQ, Feng X, Zhou W, Knyazev PG, Ullrich A, Chen Z | title = Csk-binding protein (Cbp) negatively regulates epidermal growth factor-induced cell transformation by controlling Src activation | journal = Oncogene | volume = 25 | issue = 40 | pages = 5495–506 | date = September 2006 | pmid = 16636672 | doi = 10.1038/sj.onc.1209554 | doi-access = free }}
  • {{cite journal | vauthors = Takeuchi S | title = Expression and purification of human PAG, a transmembrane adapter protein using an insect cell expression system and its structure basis | journal = The Protein Journal | volume = 25 | issue = 4 | pages = 295–9 | date = June 2006 | pmid = 16947079 | doi = 10.1007/s10930-006-9015-6 | s2cid = 11529404 }}
  • {{cite journal | vauthors = Roberts AE, Araki T, Swanson KD, Montgomery KT, Schiripo TA, Joshi VA, Li L, Yassin Y, Tamburino AM, Neel BG, Kucherlapati RS | title = Germline gain-of-function mutations in SOS1 cause Noonan syndrome | journal = Nature Genetics | volume = 39 | issue = 1 | pages = 70–4 | date = January 2007 | pmid = 17143285 | doi = 10.1038/ng1926 | s2cid = 10222262 }}
  • {{cite journal | vauthors = Smida M, Posevitz-Fejfar A, Horejsi V, Schraven B, Lindquist JA | title = A novel negative regulatory function of the phosphoprotein associated with glycosphingolipid-enriched microdomains: blocking Ras activation | journal = Blood | volume = 110 | issue = 2 | pages = 596–615 | date = July 2007 | pmid = 17389760 | doi = 10.1182/blood-2006-07-038752 | doi-access = free }}

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