PANK1
{{Short description|Protein-coding gene in the species Homo sapiens}}
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Pantothenate kinase 1 is an enzyme that in humans is encoded by the PANK1 gene.{{cite web | title = Entrez Gene: PANK1 pantothenate kinase 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=53354| accessdate = }}
This gene encodes a protein belonging to the pantothenate kinase family, which in mammals is made of up PANK1, PANK2, PANK3, and PANK4. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by CoA. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, have been identified.{{cite web | title = Entrez Gene: PANK1 pantothenate kinase 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=53354| accessdate = }}
References
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Further reading
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- {{cite journal | vauthors=Robishaw JD, Neely JR |title=Coenzyme A metabolism. |journal=Am. J. Physiol. |volume=248 |issue= 1 Pt 1 |pages= E1–9 |year= 1985 |pmid= 2981478 |doi= 10.1152/ajpendo.1985.248.1.E1}}
- {{cite journal |vauthors=Hong BS, Senisterra G, Rabeh WM, etal |title=Crystal structures of human pantothenate kinases. Insights into allosteric regulation and mutations linked to a neurodegeneration disorder. |journal=J. Biol. Chem. |volume=282 |issue= 38 |pages= 27984–93 |year= 2007 |pmid= 17631502 |doi= 10.1074/jbc.M701915200 |doi-access= free }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Deloukas P, Earthrowl ME, Grafham DV, etal |title=The DNA sequence and comparative analysis of human chromosome 10. |journal=Nature |volume=429 |issue= 6990 |pages= 375–81 |year= 2004 |pmid= 15164054 |doi= 10.1038/nature02462 |bibcode=2004Natur.429..375D |doi-access= free }}
- {{cite journal | vauthors=Ramaswamy G, Karim MA, Murti KG, Jackowski S |title=PPARalpha controls the intracellular coenzyme A concentration via regulation of PANK1alpha gene expression. |journal=J. Lipid Res. |volume=45 |issue= 1 |pages= 17–31 |year= 2004 |pmid= 14523052 |doi= 10.1194/jlr.M300279-JLR200 |doi-access= free }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal | vauthors=Westaway SK, Hayflick SJ, Zhou B, Gitschier JD |title=In reference to the Short Communication published by Ni et al. |journal=Int. J. Biochem. Cell Biol. |volume=34 |issue= 12 |pages= 1629 |year= 2003 |pmid= 12379284 |doi= 10.1016/S1357-2725(02)00125-5}}
- {{cite journal |vauthors=Zhou B, Westaway SK, Levinson B, etal |title=A novel pantothenate kinase gene (PANK2) is defective in Hallervorden-Spatz syndrome. |journal=Nat. Genet. |volume=28 |issue= 4 |pages= 345–9 |year= 2001 |pmid= 11479594 |doi= 10.1038/ng572 |s2cid=20400095 }}
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