PARD3

PARD proteins, which were first identified in C. elegans, are essential for asymmetric cell division and polarized growth, whereas CDC42 (MIM 116952) mediates the establishment of cell polarity. The CDC42 GTPase, which is controlled by nucleotide exchange factors (GEFs; see MIM 606057) and GTPase-activating proteins (GAPs; see MIM 604980), interacts with a large set of effector proteins that typically contain a CDC42/RAC (MIM 602048)-interactive binding (CRIB) domain.[supplied by OMIM]

PARD3 has been shown to interact with:

• JAM2,
• JAM3,{{cite journal | vauthors = Ebnet K, Aurrand-Lions M, Kuhn A, Kiefer F, Butz S, Zander K, Meyer zu Brickwedde MK, Suzuki A, Imhof BA, Vestweber D | title = The junctional adhesion molecule (JAM) family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3: a possible role for JAMs in endothelial cell polarity | journal = J. Cell Sci. | volume = 116 | issue = Pt 19 | pages = 3879–91 | date = Oct 2003 | pmid = 12953056 | doi = 10.1242/jcs.00704 | url = https://archive-ouverte.unige.ch/unige:11233/ATTACHMENT01 | doi-access = free }}
• PRKCI,{{cite journal | vauthors = Kohjima M, Noda Y, Takeya R, Saito N, Takeuchi K, Sumimoto H | title = PAR3beta, a novel homologue of the cell polarity protein PAR3, localizes to tight junctions | journal = Biochem. Biophys. Res. Commun. | volume = 299 | issue = 4 | pages = 641–6 | date = Dec 2002 | pmid = 12459187 | doi = 10.1016/s0006-291x(02)02698-0}} and
• PVRL3.{{cite journal | vauthors = Takekuni K, Ikeda W, Fujito T, Morimoto K, Takeuchi M, Monden M, Takai Y | title = Direct binding of cell polarity protein PAR-3 to cell-cell adhesion molecule nectin at neuroepithelial cells of developing mouse | journal = J. Biol. Chem. | volume = 278 | issue = 8 | pages = 5497–500 | date = Feb 2003 | pmid = 12515806 | doi = 10.1074/jbc.C200707200 | doi-access = free }}

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• {{cite journal | vauthors = Ebnet K, Suzuki A, Horikoshi Y, Hirose T, Meyer Zu Brickwedde MK, Ohno S, Vestweber D | title = The cell polarity protein ASIP/PAR-3 directly associates with junctional adhesion molecule (JAM). | journal = EMBO J. | volume = 20 | issue = 14 | pages = 3738–48 | year = 2001 | pmid = 11447115 | pmc = 125258 | doi = 10.1093/emboj/20.14.3738 }}
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• {{cite journal | vauthors = Kohjima M, Noda Y, Takeya R, Saito N, Takeuchi K, Sumimoto H | title = PAR3beta, a novel homologue of the cell polarity protein PAR3, localizes to tight junctions | journal = Biochem. Biophys. Res. Commun. | volume = 299 | issue = 4 | pages = 641–6 | year = 2003 | pmid = 12459187 | doi = 10.1016/S0006-291X(02)02698-0 }}
• {{cite journal | vauthors = Takekuni K, Ikeda W, Fujito T, Morimoto K, Takeuchi M, Monden M, Takai Y | title = Direct binding of cell polarity protein PAR-3 to cell-cell adhesion molecule nectin at neuroepithelial cells of developing mouse | journal = J. Biol. Chem. | volume = 278 | issue = 8 | pages = 5497–500 | year = 2003 | pmid = 12515806 | doi = 10.1074/jbc.C200707200 | doi-access = free }}
• {{cite journal | vauthors = Warner DR, Pisano MM, Roberts EA, Greene RM | title = Identification of three novel Smad binding proteins involved in cell polarity | journal = FEBS Lett. | volume = 539 | issue = 1–3 | pages = 167–73 | year = 2003 | pmid = 12650946 | doi = 10.1016/S0014-5793(03)00155-8 | doi-access = free }}
• {{cite journal | vauthors = Brajenovic M, Joberty G, Küster B, Bouwmeester T, Drewes G | title = Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network | journal = J. Biol. Chem. | volume = 279 | issue = 13 | pages = 12804–11 | year = 2004 | pmid = 14676191 | doi = 10.1074/jbc.M312171200 | doi-access = free }}
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• {{cite journal | vauthors = Liu XF, Ishida H, Raziuddin R, Miki T | title = Nucleotide exchange factor ECT2 interacts with the polarity protein complex Par6/Par3/protein kinase Czeta (PKCzeta) and regulates PKCzeta activity | journal = Mol. Cell. Biol. | volume = 24 | issue = 15 | pages = 6665–75 | year = 2004 | pmid = 15254234 | pmc = 444862 | doi = 10.1128/MCB.24.15.6665-6675.2004 }}
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