PASK
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{for|the airport in Alaska with ICAO code PASK|Selawik Airport}}
{{Infobox_gene}}
PAS domain-containing serine/threonine-protein kinase is an enzyme that in humans is encoded by the PASK gene.{{cite journal | vauthors = Hofer T, Spielmann P, Stengel P, Stier B, Katschinski DM, Desbaillets I, Gassmann M, Wenger RH | title = Mammalian PASKIN, a PAS-serine/threonine kinase related to bacterial oxygen sensors | journal = Biochem Biophys Res Commun | volume = 288 | issue = 4 | pages = 757–64 | date = Nov 2001 | pmid = 11688972 | doi = 10.1006/bbrc.2001.5840 | url = http://www.zora.uzh.ch/1428/1/Hofer_a2001MaV.pdf | access-date = 2018-12-22 | archive-date = 2013-11-02 | archive-url = https://web.archive.org/web/20131102203743/http://www.zora.uzh.ch/1428/1/Hofer_a2001MaV.pdf | url-status = dead }}{{cite journal |vauthors=Rutter J, Michnoff CH, Harper SM, Gardner KH, McKnight SL | title = PAS kinase: an evolutionarily conserved PAS domain-regulated serine/threonine kinase | journal = Proc Natl Acad Sci U S A | volume = 98 | issue = 16 | pages = 8991–6 |date=Aug 2001 | pmid = 11459942 | pmc = 55361 | doi = 10.1073/pnas.161284798 | bibcode = 2001PNAS...98.8991R | doi-access = free }}{{cite journal |vauthors=da Silva Xavier G, Rutter J, Rutter GA | title = Involvement of Per-Arnt-Sim (PAS) kinase in the stimulation of preproinsulin and pancreatic duodenum homeobox 1 gene expression by glucose | journal = Proc Natl Acad Sci U S A | volume = 101 | issue = 22 | pages = 8319–24 |date=Jun 2004 | pmid = 15148392 | pmc = 420392 | doi = 10.1073/pnas.0307737101 | bibcode = 2004PNAS..101.8319D | doi-access = free }}{{cite web | title = Entrez Gene: PASK PAS domain containing serine/threonine kinase| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23178}}
PAS domains regulate the function of many intracellular signaling pathways in response to both extrinsic and intrinsic stimuli. PASK is an evolutionarily conserved protein present in yeast, flies, and mammals.[supplied by OMIM]
References
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Further reading
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- {{cite journal |vauthors=Nakajima D, Okazaki N, Yamakawa H, etal |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones |journal=DNA Res. |volume=9 |issue= 3 |pages= 99–106 |year= 2003 |pmid= 12168954 |doi=10.1093/dnares/9.3.99 |doi-access=free |url=http://dnaresearch.oxfordjournals.org/content/9/3/99.full.pdf }}
- {{cite journal |vauthors=Nagase T, Seki N, Tanaka A, etal |title=Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1 |journal=DNA Res. |volume=2 |issue= 4 |pages= 167–74, 199–210 |year= 1996 |pmid= 8590280 |doi=10.1093/dnares/2.4.167 |doi-access=free }}
- {{cite journal |vauthors=Andersson B, Wentland MA, Ricafrente JY, etal |title=A "double adaptor" method for improved shotgun library construction |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
- {{cite journal |vauthors=Yu W, Andersson B, Worley KC, etal |title=Large-scale concatenation cDNA sequencing |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi= 10.1101/gr.7.4.353| pmc=139146 }}
- {{cite journal |vauthors=Ceulemans H, Van Eynde A, Pérez-Callejón E, etal |title=Structure and splice products of the human gene encoding sds22, a putative mitotic regulator of protein phosphatase-1 |journal=Eur. J. Biochem. |volume=262 |issue= 1 |pages= 36–42 |year= 1999 |pmid= 10231361 |doi=10.1046/j.1432-1327.1999.00344.x |doi-access=free }}
- {{cite journal |vauthors=Amezcua CA, Harper SM, Rutter J, Gardner KH |title=Structure and interactions of PAS kinase N-terminal PAS domain: model for intramolecular kinase regulation |journal=Structure |volume=10 |issue= 10 |pages= 1349–61 |year= 2003 |pmid= 12377121 |doi=10.1016/S0969-2126(02)00857-2 |doi-access=free }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
- {{cite journal |vauthors=Beausoleil SA, Jedrychowski M, Schwartz D, etal |title=Large-scale characterization of HeLa cell nuclear phosphoproteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446 |bibcode=2004PNAS..10112130B |doi-access=free }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Ewing RM, Chu P, Elisma F, etal |title=Large-scale mapping of human protein-protein interactions by mass spectrometry |journal=Mol. Syst. Biol. |volume=3 |issue= 1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 }}
- {{cite journal |vauthors=Eckhardt K, Troger J, Reissmann J, etal |title=Male germ cell expression of the PAS domain kinase PASKIN and its novel target eukaryotic translation elongation factor eEF1A1 |journal=Cell. Physiol. Biochem. |volume=20 |issue= 1–4 |pages= 227–40 |year= 2007 |pmid= 17595531 |doi= 10.1159/000104169 |doi-access= free }}
- {{cite journal |vauthors=Kikani CK, Antonysamy SA, Bonanno JB, etal |title=Structural bases of PAS domain-regulated kinase (PASK) activation in the absence of activation loop phosphorylation |journal=J. Biol. Chem. |volume=285 |issue= 52 |pages=41034–43 |year= 2010 |pmid= 20943661 |doi= 10.1074/jbc.M110.157594 |pmc=3003402|doi-access=free }}
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{{PDB Gallery|geneid=23178}}
{{Serine/threonine-specific protein kinases}}
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Category:PAS-domain-containing proteins
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