PCBP2

The protein encoded by this gene appears to be multifunctional. It along with PCBP-1 and hnRNPK corresponds to the major cellular poly(rC)-binding proteins. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-1 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure.

It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability.

This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1 intronless gene which has similar functions. This gene and PCBP-1 has paralogues PCBP3 and PCBP4 which is thought to arose as a result of duplication events of entire genes. It also has two processed pseudogenes PCBP2P1 and PCBP2P2. There are presently two alternatively spliced transcript variants described for this gene.{{cite web| title = Entrez Gene: PCBP2 poly(rC) binding protein 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5094| access-date = 2017-09-07| archive-date = 2024-04-30| archive-url = https://web.archive.org/web/20240430040833/https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=5094| url-status = live}}

In humans, the PCBP2 gene overlaps with TUC338, a transcribed ultra-conserved element implicated in Hepatocellular carcinoma.{{cite journal | vauthors = Braconi C, Valeri N, Kogure T, Gasparini P, Huang N, Nuovo GJ, Terracciano L, Croce CM, Patel T | title = Expression and functional role of a transcribed noncoding RNA with an ultraconserved element in hepatocellular carcinoma. | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 108 | issue = 2 | pages = 786–91 | date = 2011-01-11 | pmid = 21187392 | pmc = 3021052 | doi = 10.1073/pnas.1011098108 | bibcode = 2011PNAS..108..786B | doi-access = free }}

PCBP2 has been shown to interact with HNRPK,{{cite journal | vauthors = Kim JH, Hahm B, Kim YK, Choi M, Jang SK | title = Protein-protein interaction among hnRNPs shuttling between nucleus and cytoplasm | journal = J. Mol. Biol. | volume = 298 | issue = 3 | pages = 395–405 | date = May 2000 | pmid = 10772858 | doi = 10.1006/jmbi.2000.3687 }} PTBP1, and HNRNPL.

{{reflist}}

{{refbegin | 2}}

• {{cite journal | vauthors = Kiledjian M, Wang X, Liebhaber SA | title = Identification of two KH domain proteins in the alpha-globin mRNP stability complex. | journal = EMBO J. | volume = 14 | issue = 17 | pages = 4357–64 | year = 1995 | pmid = 7556077 | pmc = 394520 | doi = 10.1002/j.1460-2075.1995.tb00110.x}}
• {{cite journal | vauthors = Leffers H, Dejgaard K, Celis JE | title = Characterisation of two major cellular poly(rC)-binding human proteins, each containing three K-homologous (KH) domains. | journal = Eur. J. Biochem. | volume = 230 | issue = 2 | pages = 447–53 | year = 1995 | pmid = 7607214 | doi = 10.1111/j.1432-1033.1995.tb20581.x }}
• {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | year = 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
• {{cite journal | vauthors = Blyn LB, Swiderek KM, Richards O, Stahl DC, Semler BL, Ehrenfeld E | title = Poly(rC) binding protein 2 binds to stem-loop IV of the poliovirus RNA 5' noncoding region: identification by automated liquid chromatography-tandem mass spectrometry | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 93 | issue = 20 | pages = 11115–20 | year = 1996 | pmid = 8855318 | pmc = 38293 | doi = 10.1073/pnas.93.20.11115 | bibcode = 1996PNAS...9311115B | doi-access = free }}
• {{cite journal | vauthors = Funke B, Zuleger B, Benavente R, Schuster T, Goller M, Stévenin J, Horak I | title = The mouse poly(C)-binding protein exists in multiple isoforms and interacts with several RNA-binding proteins | journal = Nucleic Acids Res. | volume = 24 | issue = 19 | pages = 3821–8 | year = 1996 | pmid = 8871564 | pmc = 146158 | doi = 10.1093/nar/24.19.3821 }}
• {{cite journal | vauthors = Blyn LB, Towner JS, Semler BL, Ehrenfeld E | title = Requirement of poly(rC) binding protein 2 for translation of poliovirus RNA | journal = J. Virol. | volume = 71 | issue = 8 | pages = 6243–6 | year = 1997 | pmid = 9223526 | pmc = 191892 | doi = 10.1128/JVI.71.8.6243-6246.1997}}
• {{cite journal | vauthors = Kiledjian M, DeMaria CT, Brewer G, Novick K | title = Identification of AUF1 (heterogeneous nuclear ribonucleoprotein D) as a component of the alpha-globin mRNA stability complex | journal = Mol. Cell. Biol. | volume = 17 | issue = 8 | pages = 4870–6 | year = 1997 | pmid = 9234743 | pmc = 232339 | doi = 10.1128/MCB.17.8.4870}}
• {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56 | year = 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
• {{cite journal | vauthors = Czyzyk-Krzeska MF, Bendixen AC | title = Identification of the poly(C) binding protein in the complex associated with the 3' untranslated region of erythropoietin messenger RNA | journal = Blood | volume = 93 | issue = 6 | pages = 2111–20 | year = 1999 | pmid = 10068686 | doi = 10.1182/blood.V93.6.2111.406k24_2111_2120}}
• {{cite journal | vauthors = Wang Z, Day N, Trifillis P, Kiledjian M | title = An mRNA stability complex functions with poly(A)-binding protein to stabilize mRNA in vitro | journal = Mol. Cell. Biol. | volume = 19 | issue = 7 | pages = 4552–60 | year = 1999 | pmid = 10373504 | pmc = 84253 | doi = 10.1128/MCB.19.7.4552}}
• {{cite journal | vauthors = Makeyev AV, Chkheidze AN, Liebhaber SA | title = A set of highly conserved RNA-binding proteins, alphaCP-1 and alphaCP-2, implicated in mRNA stabilization, are coexpressed from an intronless gene and its intron-containing paralog | journal = J. Biol. Chem. | volume = 274 | issue = 35 | pages = 24849–57 | year = 1999 | pmid = 10455157 | doi = 10.1074/jbc.274.35.24849 | doi-access = free }}
• {{cite journal | vauthors = Kim JH, Hahm B, Kim YK, Choi M, Jang SK | title = Protein-protein interaction among hnRNPs shuttling between nucleus and cytoplasm | journal = J. Mol. Biol. | volume = 298 | issue = 3 | pages = 395–405 | year = 2000 | pmid = 10772858 | doi = 10.1006/jmbi.2000.3687 }}
• {{cite journal | vauthors = Makeyev AV, Liebhaber SA | title = Identification of two novel mammalian genes establishes a subfamily of KH-domain RNA-binding proteins | journal = Genomics | volume = 67 | issue = 3 | pages = 301–16 | year = 2000 | pmid = 10936052 | doi = 10.1006/geno.2000.6244 }}
• {{cite journal | vauthors = Chang CJ, Luh HW, Wang SH, Lin HJ, Lee SC, Hu ST | title = The heterogeneous nuclear ribonucleoprotein K (hnRNP K) interacts with dengue virus core protein | journal = DNA Cell Biol. | volume = 20 | issue = 9 | pages = 569–77 | year = 2002 | pmid = 11747608 | doi = 10.1089/104454901317094981 | url = http://ntur.lib.ntu.edu.tw//handle/246246/163267 | access-date = 2022-10-14 | archive-date = 2023-09-28 | archive-url = https://web.archive.org/web/20230928095531/http://ntur.lib.ntu.edu.tw//handle/246246/163267 | url-status = live }}
• {{cite journal | vauthors = Yeap BB, Voon DC, Vivian JP, McCulloch RK, Thomson AM, Giles KM, Czyzyk-Krzeska MF, Furneaux H, Wilce MC, Wilce JA, Leedman PJ | title = Novel binding of HuR and poly(C)-binding protein to a conserved UC-rich motif within the 3'-untranslated region of the androgen receptor messenger RNA | journal = J. Biol. Chem. | volume = 277 | issue = 30 | pages = 27183–92 | year = 2002 | pmid = 12011088 | doi = 10.1074/jbc.M202883200 | doi-access = free }}
• {{cite journal | vauthors = Walter BL, Parsley TB, Ehrenfeld E, Semler BL | title = Distinct poly(rC) binding protein KH domain determinants for poliovirus translation initiation and viral RNA replication | journal = J. Virol. | volume = 76 | issue = 23 | pages = 12008–22 | year = 2002 | pmid = 12414943 | pmc = 136902 | doi = 10.1128/JVI.76.23.12008-12022.2002 }}
• {{cite journal | vauthors = Abraham RS, Geyer SM, Price-Troska TL, Allmer C, Kyle RA, Gertz MA, Fonseca R | title = Immunoglobulin light chain variable (V) region genes influence clinical presentation and outcome in light chain-associated amyloidosis (AL) | journal = Blood | volume = 101 | issue = 10 | pages = 3801–8 | year = 2003 | pmid = 12515719 | doi = 10.1182/blood-2002-09-2707 | s2cid = 38371635 | doi-access = }}
• {{cite journal | vauthors = Pickering BM, Mitchell SA, Evans JR, Willis AE | title = Polypyrimidine tract binding protein and poly r(C) binding protein 1 interact with the BAG-1 IRES and stimulate its activity in vitro and in vivo | journal = Nucleic Acids Res. | volume = 31 | issue = 2 | pages = 639–46 | year = 2003 | pmid = 12527772 | pmc = 140511 | doi = 10.1093/nar/gkg146 }}

{{refend}}

{{PDB Gallery|geneid=5094}}

{{gene-12-stub}}