PCDH1

{{Short description|Protein-coding gene in the species Homo sapiens}}

Protocadherin-1 is a protein that in humans is encoded by the PCDH1 gene.{{cite journal |vauthors=Sano K, Tanihara H, Heimark RL, Obata S, Davidson M, St John T, Taketani S, Suzuki S | title = Protocadherins: a large family of cadherin-related molecules in central nervous system | journal = EMBO J | volume = 12 | issue = 6 | pages = 2249–56 |date=Jul 1993 | pmid = 8508762 | pmc = 413453 | doi = 10.1002/j.1460-2075.1993.tb05878.x}}{{cite web | title = Entrez Gene: PCDH1 protocadherin 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5097}}

This gene belongs to the protocadherin subfamily within the cadherin superfamily. The encoded protein is a membrane protein found at cell-cell boundaries. It is involved in neural cell adhesion, suggesting a possible role in neuronal development. The protein includes an extracellular region, containing 7 cadherin-like domains, a transmembrane region and a C-terminal cytoplasmic region. Cells expressing the protein showed cell aggregation activity. Alternative splicing occurs in this gene.

References

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PCDH1

References

Further reading