PCDH17
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Protocadherin-17 is a protein that in humans is encoded by the PCDH17 gene.{{cite journal |vauthors=Nollet F, Kools P, van Roy F | title = Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members | journal = J Mol Biol | volume = 299 | issue = 3 | pages = 551–72 |date=Jul 2000 | pmid = 10835267 | doi = 10.1006/jmbi.2000.3777 }}{{cite web | title = Entrez Gene: PCDH17 protocadherin 17| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27253}}
This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein contains six extracellular cadherin domains, a transmembrane domain, and a cytoplasmic tail differing from those of the classical cadherins. The encoded protein may play a role in the establishment and function of specific cell-cell connections in the brain. PCDH17 promoter methylation is found to be closely associated with bladder cancer malignancy {{cite journal | author = Wang XB | title = Protocadherin 17 promoter methylation in tumour tissue from patients with bladder transitional cell carcinoma. | journal = J Int Med Res | volume = 42 | issue = 2|date=Apr 2014 | pmid = 24567353 | pages = 292–9 | doi=10.1177/0300060513504364| s2cid = 38799502 | doi-access = free }}
References
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Further reading
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- {{cite journal |vauthors=Yagi T, Takeichi M |title=Cadherin superfamily genes: functions, genomic organization, and neurologic diversity |journal=Genes Dev. |volume=14 |issue= 10 |pages= 1169–80 |year= 2000 |pmid= 10817752 |doi= 10.1101/gad.14.10.1169|s2cid=44844497 |doi-access=free }}
- {{cite journal | author=Suzuki ST |title=Recent progress in protocadherin research |journal=Exp. Cell Res. |volume=261 |issue= 1 |pages= 13–8 |year= 2000 |pmid= 11082270 |doi= 10.1006/excr.2000.5039 }}
- {{cite journal |vauthors=Wu Q, Maniatis T |title=Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3124–9 |year= 2000 |pmid= 10716726 |doi= 10.1073/pnas.060027397 | pmc=16203 |bibcode=2000PNAS...97.3124W |doi-access=free }}
- {{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-style=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD | bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-style=vanc| author2=Suzuki Y | author3=Nishikawa T | display-authors=3 | last4=Otsuki | first4=Tetsuji | last5=Sugiyama | first5=Tomoyasu | last6=Irie | first6=Ryotaro | last7=Wakamatsu | first7=Ai | last8=Hayashi | first8=Koji | last9=Sato | first9=Hiroyuki |s2cid=21903526 | doi-access=free }}
- {{cite journal | author=Dunham A |title=The DNA sequence and analysis of human chromosome 13 |journal=Nature |volume=428 |issue= 6982 |pages= 522–8 |year= 2004 |pmid= 15057823 |doi= 10.1038/nature02379 | pmc=2665288 |name-list-style=vanc| author2=Matthews LH | author3=Burton J | display-authors=3 | last4=Ashurst | first4=J. L. | last5=Howe | first5=K. L. | last6=Ashcroft | first6=K. J. | last7=Beare | first7=D. M. | last8=Burford | first8=D. C. | last9=Hunt | first9=S. E. |bibcode=2004Natur.428..522D }}
- {{cite journal | author=Suzuki Y |title=Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711–8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604 | pmc=515316 |name-list-style=vanc| author2=Yamashita R | author3=Shirota M | display-authors=3 | last4=Sakakibara | first4=Y | last5=Chiba | first5=J | last6=Mizushima-Sugano | first6=J | last7=Nakai | first7=K | last8=Sugano | first8=S }}
- {{cite journal | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-style=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}
- {{cite journal | author=Kimura K |title=Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 |name-list-style=vanc| author2=Wakamatsu A | author3=Suzuki Y | display-authors=3 | last4=Ota | first4=T | last5=Nishikawa | first5=T | last6=Yamashita | first6=R | last7=Yamamoto | first7=J | last8=Sekine | first8=M | last9=Tsuritani | first9=K }}
- {{cite journal | author=Szafranski K |title=Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns |journal= Genome Biology|volume=8 |issue= 8 |pages= R154 |year= 2007|pmid= 17672918 |doi= 10.1186/gb-2007-8-8-r154 | pmc=2374985 |name-list-style=vanc| author2=Schindler S | author3=Taudien S | display-authors=3 | last4=Hiller | first4=Michael | last5=Huse | first5=Klaus | last6=Jahn | first6=Niels | last7=Schreiber | first7=Stefan | last8=Backofen | first8=Rolf | last9=Platzer | first9=Matthias |doi-access=free }}
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