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PCDH18

{{Short description|Protein-coding gene in the species Homo sapiens}}

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Protocadherin-18 is a protein that in humans is encoded by the PCDH18 gene.{{cite journal | vauthors = Nollet F, Kools P, van Roy F | title = Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members | journal = J Mol Biol | volume = 299 | issue = 3 | pages = 551–72 |date=Jul 2000 | pmid = 10835267 | doi = 10.1006/jmbi.2000.3777 }}{{cite journal | vauthors = Wolverton T, Lalande M | title = Identification and characterization of three members of a novel subclass of protocadherins | journal = Genomics | volume = 76 | issue = 1–3 | pages = 66–72 |date=Sep 2001 | pmid = 11549318 | doi = 10.1006/geno.2001.6592 }}{{cite web | title = Entrez Gene: PCDH18 protocadherin 18| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54510}}

This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. This gene encodes a protein which contains 6 extracellular cadherin domains, a transmembrane domain and a cytoplasmic tail differing from those of the classical cadherins. Although its specific function is undetermined, the cadherin-related neuronal receptor is thought to play a role in the establishment and function of specific cell-cell connections in the brain.

References

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Further reading

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  • {{cite journal | author=Suzuki ST |title=Recent progress in protocadherin research |journal=Exp. Cell Res. |volume=261 |issue= 1 |pages= 13–8 |year= 2000 |pmid= 11082270 |doi= 10.1006/excr.2000.5039 }}
  • {{cite journal | vauthors=Yagi T, Takeichi M |title=Cadherin superfamily genes: functions, genomic organization, and neurologic diversity |journal=Genes Dev. |volume=14 |issue= 10 |pages= 1169–80 |year= 2000 |pmid= 10817752 |doi= 10.1101/gad.14.10.1169|s2cid=44844497 |doi-access=free }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal | vauthors=Homayouni R, Rice DS, Curran T |title=Disabled-1 interacts with a novel developmentally regulated protocadherin |journal=Biochem. Biophys. Res. Commun. |volume=289 |issue= 2 |pages= 539–47 |year= 2002 |pmid= 11716507 |doi= 10.1006/bbrc.2001.5998 }}
  • {{cite journal |vauthors=Nagase T, Kikuno R, Nakayama M, etal |title=Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro |journal=DNA Res. |volume=7 |issue= 4 |pages= 273–81 |year= 2001 |pmid= 10997877 |doi= 10.1093/dnares/7.4.271|doi-access=free }}
  • {{cite journal | vauthors=Wu Q, Maniatis T |title=Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3124–9 |year= 2000 |pmid= 10716726 |doi= 10.1073/pnas.060027397 | pmc=16203 |doi-access=free }}

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