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PCDH8

{{Short description|Protein-coding gene in the species Homo sapiens}}

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Protocadherin-8 is a protein that in humans is encoded by the PCDH8 gene.{{cite journal | vauthors = Strehl S, Glatt K, Liu QM, Glatt H, Lalande M | title = Characterization of two novel protocadherins (PCDH8 and PCDH9) localized on human chromosome 13 and mouse chromosome 14 | journal = Genomics | volume = 53 | issue = 1 | pages = 81–9 |date=Dec 1998 | pmid = 9787079 | doi = 10.1006/geno.1998.5467 }}{{cite journal | vauthors = Strehl S, LaSalle JM, Lalande M | title = High-resolution analysis of DNA replication domain organization across an R/G-band boundary | journal = Mol Cell Biol | volume = 17 | issue = 10 | pages = 6157–66 |date=Oct 1997 | doi = 10.1128/MCB.17.10.6157 | pmid = 9315676 | pmc = 232466 }}{{cite web | title = Entrez Gene: PCDH8 protocadherin 8| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5100}}

This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The gene encodes an integral membrane protein that is thought to function in cell adhesion in a CNS-specific manner. Unlike classical cadherins, which are generally encoded by 15-17 exons, this gene includes only 3 exons. Notable is the large first exon encoding the extracellular region, including 6 cadherin domains and a transmembrane region. Alternative splicing yields isoforms with unique cytoplasmic tails.

References

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Further reading

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  • {{cite journal | vauthors=Yagi T, Takeichi M |title=Cadherin superfamily genes: functions, genomic organization, and neurologic diversity |journal=Genes Dev. |volume=14 |issue= 10 |pages= 1169–80 |year= 2000 |pmid= 10817752 |doi= 10.1101/gad.14.10.1169|s2cid=44844497 |doi-access=free }}
  • {{cite journal | vauthors=Nollet F, Kools P, van Roy F |title=Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members |journal=J. Mol. Biol. |volume=299 |issue= 3 |pages= 551–72 |year= 2000 |pmid= 10835267 |doi= 10.1006/jmbi.2000.3777 }}
  • {{cite journal | vauthors=Wu Q, Maniatis T |title=A striking organization of a large family of human neural cadherin-like cell adhesion genes |journal=Cell |volume=97 |issue= 6 |pages= 779–90 |year= 1999 |pmid= 10380929 |doi=10.1016/S0092-8674(00)80789-8 |s2cid=6014717 |doi-access=free }}
  • {{cite journal |vauthors=Yamagata K, Andreasson KI, Sugiura H, etal |title=Arcadlin is a neural activity-regulated cadherin involved in long term potentiation |journal=J. Biol. Chem. |volume=274 |issue= 27 |pages= 19473–1979 |year= 1999 |pmid= 10383464 |doi=10.1074/jbc.274.27.19473 |doi-access=free }}
  • {{cite journal | vauthors=Wu Q, Maniatis T |title=Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3124–9 |year= 2000 |pmid= 10716726 |doi= 10.1073/pnas.060027397 | pmc=16203 |doi-access=free }}
  • {{cite journal |vauthors=Wu Q, Zhang T, Cheng JF, etal |title=Comparative DNA Sequence Analysis of Mouse and Human Protocadherin Gene Clusters |journal=Genome Res. |volume=11 |issue= 3 |pages= 389–404 |year= 2001 |pmid= 11230163 |doi= 10.1101/gr.167301 | pmc=311048 }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal |vauthors=Bray NJ, Kirov G, Owen RJ, etal |title=Screening the human protocadherin 8 (PCDH8) gene in schizophrenia |journal=Genes, Brain and Behavior |volume=1 |issue= 3 |pages= 187–91 |year= 2003 |pmid= 12884975 |doi=10.1034/j.1601-183X.2002.10307.x |doi-access=free }}
  • {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
  • {{cite journal |vauthors=Lim J, Hao T, Shaw C, etal |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 |s2cid=13709685 |doi-access=free }}

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