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PCDHB2

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

Protocadherin beta-2 is a protein that in humans is encoded by the PCDHB2 gene.{{cite journal |vauthors=Wu Q, Maniatis T | title = A striking organization of a large family of human neural cadherin-like cell adhesion genes | journal = Cell | volume = 97 | issue = 6 | pages = 779–790 |date=Jul 1999 | pmid = 10380929 | doi =10.1016/S0092-8674(00)80789-8 | s2cid = 6014717 | doi-access = free }}{{cite web | title = Entrez Gene: PCDHB2 protocadherin beta 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56133}}

This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections.

References

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Further reading

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  • {{cite journal |vauthors=Yagi T, Takeichi M |title=Cadherin superfamily genes: functions, genomic organization, and neurologic diversity |journal=Genes Dev. |volume=14 |issue= 10 |pages= 1169–80 |year= 2000 |pmid= 10817752 |doi= 10.1101/gad.14.10.1169|s2cid=44844497 |doi-access=free }}
  • {{cite journal |vauthors=Nollet F, Kools P, van Roy F |title=Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members |journal=J. Mol. Biol. |volume=299 |issue= 3 |pages= 551–572 |year= 2000 |pmid= 10835267 |doi= 10.1006/jmbi.2000.3777 }}
  • {{cite journal |vauthors=Frank M, Kemler R |title=Protocadherins |journal=Curr. Opin. Cell Biol. |volume=14 |issue= 5 |pages= 557–562 |year= 2003 |pmid= 12231349 |doi=10.1016/S0955-0674(02)00365-4 }}
  • {{cite journal |vauthors=Wu Q, Maniatis T |title=Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3124–3129 |year= 2000 |pmid= 10716726 |doi= 10.1073/pnas.060027397 | pmc=16203 |doi-access=free }}
  • {{cite journal | author=Wu Q |title=Comparative DNA sequence analysis of mouse and human protocadherin gene clusters |journal=Genome Res. |volume=11 |issue= 3 |pages= 389–404 |year= 2001 |pmid= 11230163 |doi= 10.1101/gr.167301 | pmc=311048 |name-list-style=vanc| author2=Zhang T | author3=Cheng JF | display-authors=3 | last4=Kim | first4=Y | last5=Grimwood | first5=J | last6=Schmutz | first6=J | last7=Dickson | first7=M | last8=Noonan | first8=JP | last9=Zhang | first9=MQ }}
  • {{cite journal |vauthors=Vanhalst K, Kools P, Vanden Eynde E, van Roy F |title=The human and murine protocadherin-beta one-exon gene families show high evolutionary conservation, despite the difference in gene number |journal=FEBS Lett. |volume=495 |issue= 1–2 |pages= 120–125 |year= 2001 |pmid= 11322959 |doi=10.1016/S0014-5793(01)02372-9 |s2cid=36671435 |doi-access=free }}
  • {{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–16903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-style=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–45 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-style=vanc| author2=Suzuki Y | author3=Nishikawa T | display-authors=3 | last4=Otsuki | first4=Tetsuji | last5=Sugiyama | first5=Tomoyasu | last6=Irie | first6=Ryotaro | last7=Wakamatsu | first7=Ai | last8=Hayashi | first8=Koji | last9=Sato | first9=Hiroyuki |s2cid=21903526 | doi-access=free }}
  • {{cite journal | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–2127 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-style=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}

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