PCID2
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
PCI domain containing 2 is a protein that in humans is encoded by the PCID2 gene.
{{cite web
| title = Entrez Gene: PCI domain containing 2
| url = https://www.ncbi.nlm.nih.gov/gene/55795
| access-date = 2017-12-13
}}
Function
This gene encodes a component of the TREX-2 complex (transcription and export complex 2), which regulates mRNA export from the nucleus. This protein regulates expression of Mad2 mitotic arrest deficient-like 1, a cell division checkpoint protein. This protein also interacts with and stabilizes Brca2 (breast cancer 2) protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016].
References
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Further reading
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- {{cite journal |vauthors=Szafranski K, Schindler S, Taudien S, Hiller M, Huse K, Jahn N, Schreiber S, Backofen R, Platzer M |title=Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns |journal=Genome Biol. |volume=8 |issue=8 |pages=R154 |year=2007 |pmid=17672918 |pmc=2374985 |doi=10.1186/gb-2007-8-8-r154 |doi-access=free }}
- {{cite journal |vauthors=Ye B, Dai Z, Liu B, Wang R, Li C, Huang G, Wang S, Xia P, Yang X, Kuwahara K, Sakaguchi N, Fan Z |title=Pcid2 inactivates developmental genes in human and mouse embryonic stem cells to sustain their pluripotency by modulation of EID1 stability |journal=Stem Cells |volume=32 |issue=3 |pages=623–35 |year=2014 |pmid=24167073 |doi=10.1002/stem.1580 |doi-access=free }}
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