PCSK4
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Proprotein convertase subtilisin/kexin type 4 is an enzyme that in humans is encoded by the PCSK4 gene.{{cite journal | vauthors = Mbikay M, Seidah NG, Chretien M, Simpson EM | title = Chromosomal assignment of the genes for proprotein convertases PC4, PC5, and PACE 4 in mouse and human | journal = Genomics | volume = 26 | issue = 1 | pages = 123–9 |date=Jul 1995 | pmid = 7782070 | doi =10.1016/0888-7543(95)80090-9 }}{{cite web | title = Entrez Gene: PCSK4 proprotein convertase subtilisin/kexin type 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54760}}
References
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Further reading
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- {{cite journal | vauthors=Seidah NG, Chrétien M, Day R |title=The family of subtilisin/kexin like pro-protein and pro-hormone convertases: divergent or shared functions. |journal=Biochimie |volume=76 |issue= 3–4 |pages= 197–209 |year= 1995 |pmid= 7819324 |doi=10.1016/0300-9084(94)90147-3 }}
- {{cite journal | vauthors=Bassi DE, Mahloogi H, Klein-Szanto AJ |title=The proprotein convertases furin and PACE4 play a significant role in tumor progression |journal=Mol. Carcinog. |volume=28 |issue= 2 |pages= 63–9 |year= 2000 |pmid= 10900462 |doi=10.1002/1098-2744(200006)28:2<63::AID-MC1>3.0.CO;2-C |s2cid=22849623 }}
- {{cite journal | vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 |doi-access=free }}
- {{cite journal | vauthors=Malik S, Guermah M, Roeder RG |title=A dynamic model for PC4 coactivator function in RNA polymerase II transcription |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 5 |pages= 2192–7 |year= 1998 |pmid= 9482861 |doi=10.1073/pnas.95.5.2192 | pmc=19292 |bibcode=1998PNAS...95.2192M |doi-access=free }}
- {{cite journal | vauthors=Wang Z, Roeder RG |title=DNA topoisomerase I and PC4 can interact with human TFIIIC to promote both accurate termination and transcription reinitiation by RNA polymerase III |journal=Mol. Cell |volume=1 |issue= 5 |pages= 749–57 |year= 1998 |pmid= 9660958 |doi=10.1016/S1097-2765(00)80074-X |doi-access=free }}
- {{cite journal |vauthors=Li M, Mbikay M, Nakayama K, etal |title=Prohormone convertase PC4 processes the precursor of PACAP in the testis |journal=Ann. N. Y. Acad. Sci. |volume=921 |pages= 333–9 |year= 2001 |pmid= 11193847 |doi=10.1111/j.1749-6632.2000.tb06988.x |s2cid=46125753 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal |vauthors=Clark HF, Gurney AL, Abaya E, etal |title=The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 | pmc=403697 }}
- {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Qiu Q, Basak A, Mbikay M, etal |title=Role of pro-IGF-II processing by proprotein convertase 4 in human placental development |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 31 |pages= 11047–52 |year= 2005 |pmid= 16040806 |doi= 10.1073/pnas.0502357102 | pmc=1182422 |bibcode=2005PNAS..10211047Q |doi-access=free }}
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