PCTK2
{{Short description|Protein-coding gene in the species Homo sapiens}}
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Serine/threonine-protein kinase PCTAIRE-2 is an enzyme that in humans is encoded by the CDK17 gene.{{cite journal |vauthors=Hirose T, Tamaru T, Okumura N, Nagai K, Okada M | title = PCTAIRE 2, a Cdc2-related serine/threonine kinase, is predominantly expressed in terminally differentiated neurons | journal = Eur J Biochem | volume = 249 | issue = 2 | pages = 481–8 |date=Dec 1997 | pmid = 9370357 | doi =10.1111/j.1432-1033.1997.t01-1-00481.x | doi-access = }}{{cite web | title = Entrez Gene: PCTK2 PCTAIRE protein kinase 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5128}}
The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It has similarity to rat protein which is thought to play a role in terminally differentiated neurons.
References
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Further reading
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- {{cite journal | author=Meyerson M |title=A family of human cdc2-related protein kinases |journal=EMBO J. |volume=11 |issue= 8 |pages= 2909–17 |year= 1992 |pmid= 1639063 |doi= 10.1002/j.1460-2075.1992.tb05360.x| pmc=556772 | author2=Enders GH | author3=Wu CL | last4=Su | first4=LK | last5=Gorka | first5=C | last6=Nelson | first6=C | last7=Harlow | first7=E | last8=Tsai | first8=LH }}
- {{cite journal | author=Hirose T |title=Identification of tudor repeat associator with PCTAIRE 2 (Trap). A novel protein that interacts with the N-terminal domain of PCTAIRE 2 in rat brain |journal=Eur. J. Biochem. |volume=267 |issue= 7 |pages= 2113–21 |year= 2000 |pmid= 10727952 |doi=10.1046/j.1432-1327.2000.01218.x | author2=Kawabuchi M | author3=Tamaru T | last4=Okumura | first4=Nobuaki | last5=Nagai | first5=Katsuya | last6=Okada | first6=Masato }}
- {{cite journal |vauthors=Yamochi T, Nishimoto I, Okuda T, Matsuoka M |title=ik3-1/Cables is associated with Trap and Pctaire2 |journal=Biochem. Biophys. Res. Commun. |volume=286 |issue= 5 |pages= 1045–50 |year= 2001 |pmid= 11527406 |doi= 10.1006/bbrc.2001.5493 }}
- {{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 | author2=Feingold EA | author3=Grouse LH | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal | author=Conte N |title=TACC1-chTOG-Aurora A protein complex in breast cancer |journal=Oncogene |volume=22 |issue= 50 |pages= 8102–16 |year= 2003 |pmid= 14603251 |doi= 10.1038/sj.onc.1206972 | author2=Delaval B | author3=Ginestier C | last4=Ferrand | first4=Alexia | last5=Isnardon | first5=Daniel | last6=Larroque | first6=Christian | last7=Prigent | first7=Claude | last8=Séraphin | first8=Bertrand | last9=Jacquemier | first9=Jocelyne | doi-access= |s2cid=10536264 }}
- {{cite journal | author=Jin J |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436–50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051 | author2=Smith FD | author3=Stark C | last4=Wells | first4=Clark D. | last5=Fawcett | first5=James P. | last6=Kulkarni | first6=Sarang | last7=Metalnikov | first7=Pavel | last8=O'Donnell | first8=Paul | last9=Taylor | first9=Paul |s2cid=2371325 | doi-access=free |bibcode=2004CBio...14.1436J }}
- {{cite journal | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 | author2=Wagner L | author3=Feingold EA | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}
- {{cite journal | author=Barrios-Rodiles M |title=High-throughput mapping of a dynamic signaling network in mammalian cells |journal=Science |volume=307 |issue= 5715 |pages= 1621–5 |year= 2005 |pmid= 15761153 |doi= 10.1126/science.1105776 | author2=Brown KR | author3=Ozdamar B | last4=Bose | first4=R | last5=Liu | first5=Z | last6=Donovan | first6=RS | last7=Shinjo | first7=F | last8=Liu | first8=Y | last9=Dembowy | first9=J |bibcode=2005Sci...307.1621B |s2cid=39457788 }}
- {{cite journal | author=Rual JF |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 | author2=Venkatesan K | author3=Hao T | last4=Hirozane-Kishikawa | first4=Tomoko | last5=Dricot | first5=Amélie | last6=Li | first6=Ning | last7=Berriz | first7=Gabriel F. | last8=Gibbons | first8=Francis D. | last9=Dreze | first9=Matija |bibcode=2005Natur.437.1173R |s2cid=4427026 }}
- {{cite journal | author=Wissing J |title=Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry |journal=Mol. Cell. Proteomics |volume=6 |issue= 3 |pages= 537–47 |year= 2007 |pmid= 17192257 |doi= 10.1074/mcp.T600062-MCP200 | author2=Jänsch L | author3=Nimtz M | last4=Dieterich | first4=G. | last5=Hornberger | first5=R. | last6=Keri | first6=G. | last7=Wehland | first7=J. | last8=Daub | first8=H. | doi-access=free | hdl=10033/19756 | hdl-access=free }}
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{{Serine/threonine-specific protein kinases}}
{{Enzymes}}
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