PDCD4

This gene encodes a protein localized to the nucleus in proliferating cells. Expression of this gene is modulated by cytokines in natural killer and T cells. The gene product is thought to play a role in apoptosis but the specific role has not yet been determined. Two transcripts encoding different isoforms have been identified.

PDCD4 has been shown to interact with RPS13,{{cite journal | vauthors = Kang MJ, Ahn HS, Lee JY, Matsuhashi S, Park WY | title = Up-regulation of PDCD4 in senescent human diploid fibroblasts | journal = Biochemical and Biophysical Research Communications | volume = 293 | issue = 1 | pages = 617–21 | year = 2002 | pmid = 12054647 | doi = 10.1016/S0006-291X(02)00264-4 }} ribosomal protein L5, p62, LC3 and Ubiquitin [9]

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9. Manirujjaman M, Ozaki I, Murata Y, Guo J, Xia J, Nishioka K, Perveen R, Takahashi H, Anzai K, Matsuhashi S (2020). "Degradation of the Tumor Suppressor PDCD4 Is Impaired by the Suppression of p62/SQSTM1 and Autophagy". Cells. 9(1): 218. doi.org/10.3390/cells9010218.

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• {{cite journal | vauthors = Göke R, Gregel C, Göke A, Arnold R, Schmidt H, Lankat-Buttgereit B | title = Programmed Cell Death Protein 4 (PDCD4) Acts As a Tumor Suppressor in Neuroendocrine Tumor Cells | journal = Annals of the New York Academy of Sciences | volume = 1014 | pages = 220–1 | year = 2004 | issue = 1 | pmid = 15153438 | doi = 10.1196/annals.1294.024 | bibcode = 2004NYASA1014..220G | s2cid = 9284462 }}
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• {{cite journal | vauthors = Yoshinaga H, Matsuhashi S, Fujiyama C, Masaki Z | title = Novel human PDCD4 (H731) gene expressed in proliferative cells is expressed in the small duct epithelial cells of the breast as revealed by an anti-H731 antibody | journal = Pathology International | volume = 49 | issue = 12 | pages = 1067–77 | year = 1999 | pmid = 10632927 | doi = 10.1046/j.1440-1827.1999.00995.x | s2cid = 968499 }}
• {{cite journal |pages=113–4 |doi=10.1159/000015408 |pmid=10640828 |title=Assignment¹ of the programmed cell death 4 gene (PDCD4) to human chromosome band 10q24 by in situ hybridization |year=1999 |last1=Soejima |first1=H. |last2=Miyoshi |first2=O. |last3=Yoshinaga |first3=H. |last4=Masaki |first4=Z. |last5=Ozaki |first5=I. |last6=Kajiwara |first6=S. |last7=Niikawa |first7=N. |last8=Matsuhashi |first8=S. |last9=Mukai |first9=T. |journal=Cytogenetic and Genome Research |volume=87|issue=1–2 |s2cid=34560093 }}
• {{cite journal | vauthors = Kang MJ, Ahn HS, Lee JY, Matsuhashi S, Park WY | title = Up-regulation of PDCD4 in senescent human diploid fibroblasts | journal = Biochemical and Biophysical Research Communications | volume = 293 | issue = 1 | pages = 617–21 | year = 2002 | pmid = 12054647 | doi = 10.1016/S0006-291X(02)00264-4 }}
• {{cite journal | vauthors = Chen Y, Knösel T, Kristiansen G, Pietas A, Garber ME, Matsuhashi S, Ozaki I, Petersen I | title = Loss of PDCD4 expression in human lung cancer correlates with tumour progression and prognosis | journal = The Journal of Pathology | volume = 200 | issue = 5 | pages = 640–6 | year = 2003 | pmid = 12898601 | doi = 10.1002/path.1378 | s2cid = 25899458 }}
• {{cite journal | vauthors = Yang HS, Cho MH, Zakowicz H, Hegamyer G, Sonenberg N, Colburn NH | title = A Novel Function of the MA-3 Domains in Transformation and Translation Suppressor Pdcd4 is Essential for Its Binding to Eukaryotic Translation Initiation Factor 4A | journal = Molecular and Cellular Biology | volume = 24 | issue = 9 | pages = 3894–906 | year = 2004 | pmid = 15082783 | pmc = 387765 | doi = 10.1128/MCB.24.9.3894-3906.2004 }}
• {{cite journal | vauthors = Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC | title = Robust Phosphoproteomic Profiling of Tyrosine Phosphorylation Sites from Human T Cells Using Immobilized Metal Affinity Chromatography and Tandem Mass Spectrometry | journal = Analytical Chemistry | volume = 76 | issue = 10 | pages = 2763–72 | year = 2004 | pmid = 15144186 | doi = 10.1021/ac035352d }}
• {{cite journal | vauthors = Göke R, Barth P, Schmidt A, Samans B, Lankat-Buttgereit B | title = Programmed cell death protein 4 suppresses CDK1/cdc2 via induction of p21Waf1/Cip1 | journal = AJP: Cell Physiology | volume = 287 | issue = 6 | pages = C1541–6 | year = 2004 | pmid = 15317660 | doi = 10.1152/ajpcell.00025.2004 | s2cid = 83565566 }}
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• {{cite journal | vauthors = Palamarchuk A, Efanov A, Maximov V, Aqeilan RI, Croce CM, Pekarsky Y | title = Akt Phosphorylates and Regulates Pdcd4 Tumor Suppressor Protein | journal = Cancer Research | volume = 65 | issue = 24 | pages = 11282–6 | year = 2005 | pmid = 16357133 | doi = 10.1158/0008-5472.CAN-05-3469 | doi-access = free }}
• {{cite journal | vauthors = Yang HS, Matthews CP, Clair T, Wang Q, Baker AR, Li CC, Tan TH, Colburn NH | title = Tumorigenesis Suppressor Pdcd4 Down-Regulates Mitogen-Activated Protein Kinase Kinase Kinase Kinase 1 Expression to Suppress Colon Carcinoma Cell Invasion | journal = Molecular and Cellular Biology | volume = 26 | issue = 4 | pages = 1297–306 | year = 2006 | pmid = 16449643 | pmc = 1367180 | doi = 10.1128/MCB.26.4.1297-1306.2006 }}

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